Cited by 62Stress Responses and CortisolTryptophan and brain disordersAdrenal Hormones and Disorders

A further exploration of the relationships between immune parameters and the HPA-axis activity in depressed patients

Maes, M., Bosmans, E., Suy, E., Minner, B., Raus, J.·1991·Psychological Medicine

Abstract

In order to investigate the relationship between the immune apparatus and the hypothalamic-pituitary-adrenal (HPA)-axis activity in depressed patients, we measured in vitro lymphocyte responses to the mitogens Phytohaemagglutinin (PHA), Pokeweed (PWM) and Concanavalin A (Con A) and 8 a.m. baseline cortisol values in plasma, free cortisol excretion in 24 h urine (UFC), basal and post-dexamethasone beta-endorphin values. Major depressed patients with melancholia/psychotic features exhibited a significantly lower mitogen-induced blast transformation as compared to minor and simple major depressed patients. The lymphocyte responses to the three mitogens were significantly inversely related to baseline cortisol values and postdexamethasone beta-endorphin values. The proliferative capacity of lymphocytes to stimulation with PHA and PWM was significantly and positively related to UFC excretion. Up to 45% of the variance in the immune-responses to the mitogens was explained by the baseline cortisol, post-dexamethasone beta-endorphin and UFC values.

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Crossref · 10.1017/s0033291700020419

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69 of 69 references verified0 citation errors · 0 not checkable

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  • Depressed patients have changes in the immune system.

    “Since the observation that depressed patients have changes in the immune system [136,137]”

    From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [136]

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Authors
Maes, M., Bosmans, E., Suy, E., Minner, B., & Raus, J.
Affiliations
Psychiatriezentrum Münsingen (CH)
Corresponding author
Maes, M.
Venue
Psychological Medicine
Published
1991-05
Volume
21
Issue
2
Pages
313-320
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
OpenAlex
W2171529630
Cited by
62
References
69
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2019: 3 · 2014: 1 · 2013: 1
FWCI
4.73
Type
journal article
Language
en
Open access
closed
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Document Server@UHasselt (UHasselt) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
depression, hypothalamic-pituitary-adrenal axis, immune function, lymphocyte mitogen response, phytohemagglutinin, pokeweed mitogen, concanavalin A, cortisol, urinary free cortisol, dexamethasone, beta-endorphin, melancholia, psychopharmacology
MeSH terms
Adult, beta-Endorphin, Depressive Disorder, Dexamethasone, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Immune Tolerance, Lymphocyte Activation, Male, Middle Aged, Pituitary-Adrenal System, Prospective Studies

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