A further exploration of the relationships between immune parameters and the HPA-axis activity in depressed patients
Abstract
In order to investigate the relationship between the immune apparatus and the hypothalamic-pituitary-adrenal (HPA)-axis activity in depressed patients, we measured in vitro lymphocyte responses to the mitogens Phytohaemagglutinin (PHA), Pokeweed (PWM) and Concanavalin A (Con A) and 8 a.m. baseline cortisol values in plasma, free cortisol excretion in 24 h urine (UFC), basal and post-dexamethasone beta-endorphin values. Major depressed patients with melancholia/psychotic features exhibited a significantly lower mitogen-induced blast transformation as compared to minor and simple major depressed patients. The lymphocyte responses to the three mitogens were significantly inversely related to baseline cortisol values and postdexamethasone beta-endorphin values. The proliferative capacity of lymphocytes to stimulation with PHA and PWM was significantly and positively related to UFC excretion. Up to 45% of the variance in the immune-responses to the mitogens was explained by the baseline cortisol, post-dexamethasone beta-endorphin and UFC values.
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Depressed patients have changes in the immune system.
“Since the observation that depressed patients have changes in the immune system [136,137]”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [136]
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- Authors
- Maes, M., Bosmans, E., Suy, E., Minner, B., & Raus, J.
- Affiliations
- Psychiatriezentrum Münsingen (CH)
- Corresponding author
- Maes, M.
- ORCID
- Maes, M.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 1991-05
- Volume
- 21
- Issue
- 2
- Pages
- 313-320
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2171529630
- Cited by
- 62
- References
- 69
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2019: 3 · 2014: 1 · 2013: 1
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Document Server@UHasselt (UHasselt) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- depression, hypothalamic-pituitary-adrenal axis, immune function, lymphocyte mitogen response, phytohemagglutinin, pokeweed mitogen, concanavalin A, cortisol, urinary free cortisol, dexamethasone, beta-endorphin, melancholia, psychopharmacology
- MeSH terms
- Adult, beta-Endorphin, Depressive Disorder, Dexamethasone, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Immune Tolerance, Lymphocyte Activation, Male, Middle Aged, Pituitary-Adrenal System, Prospective Studies
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