Cited by 311HIV/AIDS Research and InterventionsHIV Research and TreatmentHIV-related health complications and treatments

Progression to AIDS, a clinical AIDS condition and mortality: psychosocial and physiological predictors

LESERMAN, J., PETITTO, J. M., GU, H., GAYNES, B. N., BARROSO, J., GOLDEN, R. N., PERKINS, D. O., FOLDS, J. D. +1 more·2002·Psychological Medicine

Abstract

BACKGROUND: The primary aim of this study is to examine prospectively the association of stressful life events, social support, depressive symptoms, anger, serum cortisol and lymphocyte subsets with changes in multiple measures of human immunodeficiency virus (HIV) disease progression. METHODS: Ninety-six HIV-infected gay men without symptoms or anti-retroviral medication use at baseline were studied every 6 months for up to 9 years. Disease progression was defined in three ways using the Centers for Disease Control (CDC) classifications (e.g. AIDS, clinical AIDS condition and mortality). Cox regression models with time-dependent covariates were used, adjusting for control variables (e.g. race, age, baseline, CD4 T cells and viral load, number of anti-retroviral medications). RESULTS: Higher cumulative average stressful life events and lower cumulative average social support predicted faster progression to both the CDC AIDS classification and a clinical AIDS condition. Higher anger scores and CD8 T cells were associated with faster progression to AIDS, and depressive symptoms were associated with faster development of an AIDS clinical condition. Higher levels of serum cortisol predicted all three measures of disease progression. CONCLUSIONS: These results suggest that stressful life events, dysphoric mood and limited social support are associated with more rapid clinical progression in HIV infection, with serum cortisol also exerting an independent effect on disease progression.

Integrity signals

Registry

Crossref · 10.1017/s0033291702005949

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
LESERMAN, J., PETITTO, J. M., GU, H., GAYNES, B. N., BARROSO, J., GOLDEN, R. N., PERKINS, D. O., FOLDS, J. D., & EVANS, D. L.
Affiliations
University of North Carolina at Chapel Hill (US)
Venue
Psychological Medicine
Published
2002-08
Volume
32
Issue
6
Pages
1059-1073
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
OpenAlex
W1974972585
Cited by
311
References
40
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 10 · 2017: 13 · 2016: 14 · 2015: 14 · 2014: 16 · 2013: 13 · 2012: 25
FWCI
8.83
Type
journal article
Language
en
Open access
closed
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh044618-14)
  • National Institute of Mental Health (MH 33127, MH 44618)
  • National Institute of Allergy and Infectious Diseases (P30 AI49365)
  • National Center for Research Resources (RR00046, M01RR000046)
Topics
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
Keywords
HIV disease progression, AIDS, gay men, life events, social support, depressive symptoms, anger, serum cortisol, CD8+ T cells, lymphocyte subsets, psychosocial predictors, mortality, psychobiology
MeSH terms
Acquired Immunodeficiency Syndrome, Adolescent, Adult, Anger, Depression, Humans, Hydrocortisone, Life Change Events, Male, Middle Aged, Prospective Studies, Sampling Studies, Social Support, Stress, Psychological, HIV Infections, Disease Progression, Homosexuality, Male, CD4 Lymphocyte Count

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review