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Cited by 530Treatment of Major DepressionNeural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 85 of the 87 references it cites were found in a registry or an index.

Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions

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Bench, C. J., Friston, K. J., Brown, R. G., Frackowiak, R. S. J., Dolan, R. J.·1993·Psychological Medicine
DOI 10.1017/s0033291700025368
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Abstract

Synopsis: We have previously reported focal abnormalities of regional cerebral blood flow (rCBF) in a group of 33 patients with major depression. This report, on an extended sample of 40 patients who demonstrated identical regional deficits to those previously described, examines the relationships between depressive symptoms and patterns of rCBF. Patients' symptom ratings were subjected to factor analysis, producing a three-factor solution. The scores for these three factors, which corresponded to recognizable dimensions of depressive illness, were then correlated with rCBF. The first factor had high loadings for anxiety and correlated positively with rCBF in the posterior cingulate cortex and inferior parietal lobule bilaterally. The second factor had high loadings for psychomotor retardation and depressed mood and correlated negatively with rCBF in the left dorsolateral prefrontal cortex and left angular gyrus. The third factor had a high loading for cognitive performance and correlated positively with rCBF in the left medial prefrontal cortex. These data indicate that symptomatic specificity may be ascribed to regional functional deficits in major depressive illness.

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Citations

Cites

Show all 87 references

Research works printed but not linked: 9

  1. Spitzer, 1977, Research Diagnostic Criteria for a Selected Group of Functional Disorders
  2. Goldstein, 1985, Age related-decline of rCBF in schizophrenia and major affective disorder, Journal of Cerebral Blood Flow and Metabolism, 5, 203
  3. Goldman-Rakic, 1986, Handbook of Physiology – The Nervous System V, 373
  4. Bailey, 1991, Physical validation of statistical parametric mapping, Journal of Cerebral Blood Flow and Metabolism, 11, S150
  5. Sackeim, 1987, Cerebral Dynamics, Laterality, and Psychopathology, 273
  6. Friston, 1991, Brainwork 2: Alfred Benzon Symposium, 1
  7. 10.1001/jama.1987.03400100102031 · DOI
  8. 1980, Diagnostic and Statistical Manual of Mental Disorders
  9. Drevets, 1989, Trait and state cerebral blood flow abnormalities in depression, Society for Neuroscience Abstracts, 15, 30

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Metadata

Authors
Bench, C. J., Friston, K. J., Brown, R. G., Frackowiak, R. S. J., & Dolan, R. J.
Affiliations
The Royal Free Hospital (GB)
Corresponding author
Bench, C. J.
ORCID
Venue
Psychological Medicine
Publisher
Cambridge University Press (CUP)
Published
1993-08
Volume
23
Issue
3
Pages
579-590
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
DOI
10.1017/s0033291700025368
OpenAlex
W1969717350
Cited by
530
References
87
Citations by year
2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 8 · 2019: 3 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 13 · 2014: 16 · 2013: 9 · 2012: 19
FWCI
19.25
Type
journal article
Language
en
Open access
Licence
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Max Planck Digital Library (submittedVersion, other-oa)
  • Research Portal (King's College London) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders
Wellcome Trust
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
major depressive disorder, regional cerebral blood flow, anxiety, psychomotor retardation, depressive mood, cognitive performance, posterior cingulate cortex, inferior parietal lobule, dorsolateral prefrontal cortex, angular gyrus, medial prefrontal cortex
MeSH terms
Adult, Brain, Brain Diseases, Cerebrovascular Circulation, Depressive Disorder, Female, Glucose, Humans, Functional Laterality, Parietal Lobe, Psychological Tests, Psychomotor Disorders, Radiography, Tomography, Emission-Computed, Antipsychotic Agents, Neurotransmitter Agents

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