The DOI matches its Crossref record; 85 of the 87 references it cites were found in a registry or an index.
Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions
Open accessAbstract
Synopsis: We have previously reported focal abnormalities of regional cerebral blood flow (rCBF) in a group of 33 patients with major depression. This report, on an extended sample of 40 patients who demonstrated identical regional deficits to those previously described, examines the relationships between depressive symptoms and patterns of rCBF. Patients' symptom ratings were subjected to factor analysis, producing a three-factor solution. The scores for these three factors, which corresponded to recognizable dimensions of depressive illness, were then correlated with rCBF. The first factor had high loadings for anxiety and correlated positively with rCBF in the posterior cingulate cortex and inferior parietal lobule bilaterally. The second factor had high loadings for psychomotor retardation and depressed mood and correlated negatively with rCBF in the left dorsolateral prefrontal cortex and left angular gyrus. The third factor had a high loading for cognitive performance and correlated positively with rCBF in the left medial prefrontal cortex. These data indicate that symptomatic specificity may be ascribed to regional functional deficits in major depressive illness.
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“For example, psychomotor retardation is associated with reduced activity in higher-order prefrontal regions that connect to the basal ganglia and are associated with the initiation, planning, and control of movement, including the dlPFC and orbitofrontal cortex (Bench et al., 1993; Videbech et al., 2002).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Bench et al., 1993
In the citing paper
“In addition to depression, a broad range of emotional disturbances characterized by persistent negative affect are associated with poor emotional regulation, high emotional reactivity and/or poor prefrontal control (Baxter et al., 1989; Bench, Friston, Brown, Frackowiak, & Dolan, 1993; Clark, Chamberlain, & Sahakian, 2009; Couyoumdjian et al., 2009; Hemenover, 2003; Mayberg et al., 1999; Meyer et”
From Mindfulness-Based Cognitive Therapy Improves Emotional Reactivity to Social Stress: Results from a Randomized Controlled Trial (2012) · cites this paper as Bench, Friston, Brown, Frackowiak, & Dolan, 1993
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Metadata
- Authors
- Bench, C. J., Friston, K. J., Brown, R. G., Frackowiak, R. S. J., & Dolan, R. J.
- Affiliations
- The Royal Free Hospital (GB)
- Corresponding author
- Bench, C. J.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 1993-08
- Volume
- 23
- Issue
- 3
- Pages
- 579-590
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W1969717350
- Cited by
- 530
- References
- 87
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 8 · 2019: 3 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 13 · 2014: 16 · 2013: 9 · 2012: 19
- FWCI
- 19.25
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, regional cerebral blood flow, anxiety, psychomotor retardation, depressive mood, cognitive performance, posterior cingulate cortex, inferior parietal lobule, dorsolateral prefrontal cortex, angular gyrus, medial prefrontal cortex
- MeSH terms
- Adult, Brain, Brain Diseases, Cerebrovascular Circulation, Depressive Disorder, Female, Glucose, Humans, Functional Laterality, Parietal Lobe, Psychological Tests, Psychomotor Disorders, Radiography, Tomography, Emission-Computed, Antipsychotic Agents, Neurotransmitter Agents
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