Neuropsychological dysfunction in depression: the relationship to regional cerebral blood flow
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Synopsis: The relationship between neuropsychological test performance and regional cerebral blood flow (rCBF) was examined in 29 patients meeting Research Diagnostic Criteria (RDC) for major depression. Following a comprehensive neuropsychological assessment two subsets of tests, comprising tests that discriminated between patients and controls or between patients with varying degrees of global cognitive impairment, were selected. These subtests were entered into a principal components analysis (PCA) which generated a two-factor solution, accounting for 50% of the overall variance in test scores. Individual patient loadings on each of these factors were subsequently correlated with regional cerebral blood flow (rCBF), as measured by positron emission tomography (PET). Both factors demonstrated significant correlations with rCBF in the medial prefrontal cortex and frontal polar cortex while for each factor there were also unique patterns of correlations with posterior brain regions. The findings provide additional evidence that neuropsychological deficits in depression are associated with abnormalities in regional brain function and in particular with the function of the medial prefrontal cortex.
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Clinical imaging studies have demonstrated robust structural and functional deficits in the PFC across a range of disorders including depression, bipolar disorder, anxiety, OCD, schizophrenia, PTSD, alcohol abuse disorder, and substance abuse disorder.
“Clinical imaging studies have confirmed the results of these studies, demonstrating robust structural and functional deficits in the PFC across a range of disorders including depression, bipolar disorder, anxiety, obsessive compulsive disorder (OCD), schizophrenia, PTSD, alcohol abuse disorder, and substance abuse disorder (84–103).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [84]
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- Authors
- Dolan, R. J., Bench, C. J., Brown, R. G., Scott, L. C., & Frackowiak, R. S. J.
- Affiliations
- The Royal Free Hospital (GB)
- Corresponding author
- Dolan, R. J.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 1994-11
- Volume
- 24
- Issue
- 4
- Pages
- 849-857
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2024256650
- Cited by
- 155
- References
- 5
- Citations by year
- 2022: 2 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, neuropsychological dysfunction, regional cerebral blood flow, medial prefrontal cortex, cognitive impairment, positron emission tomography
- MeSH terms
- Adult, Aged, Attention, Brain Mapping, Cerebral Cortex, Cognition Disorders, Dementia, Depressive Disorder, Female, Frontal Lobe, Humans, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Paired-Associate Learning, Mental Recall, Regional Blood Flow, Retention, Psychology, Tomography, Emission-Computed, Prefrontal Cortex
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