Cited by 530Treatment of Major DepressionNeural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions

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Bench, C. J., Friston, K. J., Brown, R. G., Frackowiak, R. S. J., Dolan, R. J.·1993·Psychological Medicine

DOI 10.1017/s0033291700025368

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Abstract

Synopsis: We have previously reported focal abnormalities of regional cerebral blood flow (rCBF) in a group of 33 patients with major depression. This report, on an extended sample of 40 patients who demonstrated identical regional deficits to those previously described, examines the relationships between depressive symptoms and patterns of rCBF. Patients' symptom ratings were subjected to factor analysis, producing a three-factor solution. The scores for these three factors, which corresponded to recognizable dimensions of depressive illness, were then correlated with rCBF. The first factor had high loadings for anxiety and correlated positively with rCBF in the posterior cingulate cortex and inferior parietal lobule bilaterally. The second factor had high loadings for psychomotor retardation and depressed mood and correlated negatively with rCBF in the left dorsolateral prefrontal cortex and left angular gyrus. The third factor had a high loading for cognitive performance and correlated positively with rCBF in the left medial prefrontal cortex. These data indicate that symptomatic specificity may be ascribed to regional functional deficits in major depressive illness.

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Authors: Bench, C. J., Friston, K. J., Brown, R. G., Frackowiak, R. S. J., & Dolan, R. J.
Affiliations: The Royal Free Hospital (GB)
Corresponding author: Bench, C. J.
ORCID: Bench, C. J.
Friston, K. J.
Brown, R. G.
Frackowiak, R. S. J.
Dolan, R. J.
Venue: Psychological Medicine
Publisher: Cambridge University Press (CUP)
Published: 1993-08
Volume: 23
Issue: 3
Pages: 579-590
ISSN: 0033-2917 (ISSN-L)
1469-8978
DOI: 10.1017/s0033291700025368
OpenAlex: W1969717350
Cited by: 530
References: 87
Citations by year: 2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 8 · 2019: 3 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 13 · 2014: 16 · 2013: 9 · 2012: 19
FWCI: 19.25
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.cambridge.org/core/terms (unspecified, 5821 d)
Locations: Psychological Medicine (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Max Planck Digital Library (submittedVersion, other-oa)
Research Portal (King's College London) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders: Wellcome Trust
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: major depressive disorder, regional cerebral blood flow, anxiety, psychomotor retardation, depressive mood, cognitive performance, posterior cingulate cortex, inferior parietal lobule, dorsolateral prefrontal cortex, angular gyrus, medial prefrontal cortex
MeSH terms: Adult, Brain, Brain Diseases, Cerebrovascular Circulation, Depressive Disorder, Female, Glucose, Humans, Functional Laterality, Parietal Lobe, Psychological Tests, Psychomotor Disorders, Radiography, Tomography, Emission-Computed, Antipsychotic Agents, Neurotransmitter Agents

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Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions

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