The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
Remission and relapse in major depression: a two-year prospective follow-up study
Abstract
Synopsis: This paper reports the course with respect to remission and relapse of a cohort of predominantly in-patient RDC major depressive subjects, who were followed at 3-monthly intervals to remission and for up to 15 months thereafter. Remission was comparatively rapid with 70% of subjects remitting within 6 months. Only 6% failed to do so by 15 months. However, 40% relapsed over the subsequent 15 months, with all the relapses occurring in the first 10 months. Greater severity of the depression and longer duration of the illness predicted a longer time to remission. Greater initial severity of depression also predicted relapse. Subjects with a worse outcome had not received less adequate treatment than the remainder. Our results confirm the comparatively poor outcome subsequent to remission that has been reported in recent literature, in spite of the availability of modern methods of treatment. The clustering of relapses in the first 10 months gives some support to the distinction between relapse and later recurrence.
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“The benefits are also likely to be temporary, with studies showing 29–54% relapse rates during the time span of 1–2 years posttreatment (Dobson et al., 2008; Gortner, Gollan, Dobson, & Jacobson, 1998; Ramana et al., 1995; Shea et al., 1992; Vittengl, Clark, Dunn, & Jarrett, 2007).”
From A mindful yoga intervention for young women with major depressive disorder: Design and baseline sample characteristics of a randomized controlled trial (2020) · cites this paper as Ramana et al., 1995
In the citing paper
“and (c) relapse (Dobson et al., 2008; Gortner et al., 1998; Ramana et al., 1995; Shea et al., 1992; Vittengl et al., 2007)”
From A mindful yoga intervention for young women with major depressive disorder: Design and baseline sample characteristics of a randomized controlled trial (2020) · cites this paper as Ramana et al., 1995
In the citing paper
“Subjective experiences of loneliness are distinctive aspects of the phenomenology of depression among youth across cultural groups in high-income and lowand middle-income countries. 124-126”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [125]
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Cited by
Sorted by citations
Keyes, C. L. M. (2007) · American Psychologist · doi:10.1037/0003-066x.62.2.95 · Cited by 2,268
“The remission of mental illness using current pharmacotherapies or psychotherapies is partial or short lived, and as much as one third of patients do not respond to the recommended treatments (Keller, Shapiro, Lavori, & Wolfe, 1982; O’Reardon, Brunswick, & Amsterdam, 2000; Ramana et al., 1995).”
BackgroundTime for united action on depression: a Lancet–World Psychiatric Association Commission
Herrman, H., Patel, V., Kieling, C., Berk, M., Buchweitz, C., Cuijpers, P., Furukawa, T. A., Kessler, R. C., Kohrt, B. A., Maj, M., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02141-3 · Cited by 1,104
Risk for recurrence in depression
Burcusa, S. L., & Iacono, W. G. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2007.02.005 · Cited by 1,023
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Malhi, G. S., Bassett, D., Boyce, P., Bryant, R., Fitzgerald, P. B., Fritz, K., Hopwood, M., Lyndon, B., Mulder, R., Murray, G., et al. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415617657 · Cited by 842
“Particular attention should be paid to minimising or ameliorating residual symptoms, which are strongly linked to increased relapse rates (Kessing and Andersen, 2005; Ramana et al., 1995).”
Background
Metadata
- Authors
- Ramana, R., Paykel, E. S., Cooper, Z., Hayhurst, H., Saxty, M., & Surtees, P. G.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Ramana, R.
- ORCID
- Cooper, Z.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 1995-11
- Volume
- 25
- Issue
- 6
- Pages
- 1161-1170
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2099075065
- Cited by
- 236
- References
- 53
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 9 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 5 · 2012: 10
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, remission, relapse, recurrence, inpatient depression, depression severity, disease duration, treatment outcomes, recurrence prediction
- MeSH terms
- Adolescent, Adult, Aged, Antidepressive Agents, Depressive Disorder, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Psychiatric Status Rating Scales, Recurrence, Remission, Spontaneous
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