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Cited by 236Treatment of Major DepressionMental Health Treatment and AccessAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.

Remission and relapse in major depression: a two-year prospective follow-up study

Ramana, R., Paykel, E. S., Cooper, Z., Hayhurst, H., Saxty, M., Surtees, P. G.·1995·Psychological Medicine
DOI 10.1017/s0033291700033134
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Abstract

Synopsis: This paper reports the course with respect to remission and relapse of a cohort of predominantly in-patient RDC major depressive subjects, who were followed at 3-monthly intervals to remission and for up to 15 months thereafter. Remission was comparatively rapid with 70% of subjects remitting within 6 months. Only 6% failed to do so by 15 months. However, 40% relapsed over the subsequent 15 months, with all the relapses occurring in the first 10 months. Greater severity of the depression and longer duration of the illness predicted a longer time to remission. Greater initial severity of depression also predicted relapse. Subjects with a worse outcome had not received less adequate treatment than the remainder. Our results confirm the comparatively poor outcome subsequent to remission that has been reported in recent literature, in spite of the availability of modern methods of treatment. The clustering of relapses in the first 10 months gives some support to the distinction between relapse and later recurrence.

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Crossref · 10.1017/s0033291700033134

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52 of 52 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 4

  1. 10.1001/jama.1984.03350060032024 · DOI · Paper page
  2. 1993, Practice Guideline for Major Depressive Disorder in Adults, American Journal of Psychiatry, 150
  3. 1992, The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines
  4. Wing, 1974, The Measurements and Classification of Psychiatric Symptoms

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Metadata

Authors
Ramana, R., Paykel, E. S., Cooper, Z., Hayhurst, H., Saxty, M., & Surtees, P. G.
Affiliations
University of Cambridge (GB)
Corresponding author
Ramana, R.
ORCID
Cooper, Z.
Venue
Psychological Medicine
Publisher
Cambridge University Press (CUP)
Published
1995-11
Volume
25
Issue
6
Pages
1161-1170
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
DOI
10.1017/s0033291700033134
OpenAlex
W2099075065
Cited by
236
References
53
Citations by year
2025: 4 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 9 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 5 · 2012: 10
FWCI
3.88
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified, 4999 d)
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
major depressive disorder, remission, relapse, recurrence, inpatient depression, depression severity, disease duration, treatment outcomes, recurrence prediction
MeSH terms
Adolescent, Adult, Aged, Antidepressive Agents, Depressive Disorder, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Psychiatric Status Rating Scales, Recurrence, Remission, Spontaneous

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