Cited by 117Bipolar Disorder and TreatmentSchizophrenia research and treatmentGenetic Associations and Epidemiology

Are auditory P300 and duration MMN heritable and putative endophenotypes of psychotic bipolar disorder? A Maudsley Bipolar Twin and Family Study

Hall, M.-H., Schulze, K., Rijsdijk, F., Kalidindi, S., McDonald, C., Bramon, E., Murray, R. M., Sham, P.·2009·Psychological Medicine

Abstract

Background: Impaired P300 auditory response has been reported in patients with psychotic bipolar disorder (BPD) and unaffected relatives of psychotic bipolar patients. Deficits in mismatch negativity (MMN), however, have not been observed in bipolar patients. To our knowledge, no family study of MMN in BPD has been reported. The current study combined the Maudsley twin and bipolar family samples using genetic model fitting analyses to: (1) assess the relationship between BPD and MMN, (2) substantiate the association between psychotic BPD and P300 variables, (3) verify the genetic overlap of BPD with P300 amplitude previously reported in the twin sample, and (4) examine the shared genetic influences between BPD and bilateral temporal scalp locations of P300 components. Method: A total of 301 subjects were included in this study, including 94 twin pairs, 31 bipolar families, and 39 unrelated healthy controls. Statistical analyses were based on structural equation modelling. Results: Both P300 and MMN are heritable, with heritability estimates of 0.58 for MMN, 0.68–0.80 for P300 amplitude, and 0.21–0.56 for P300 latency. The bipolar patients and their relatives showed normal MMN. No significant association, either genetic or environmental, was found with BPD. BPD was significantly associated with reduced P300 amplitude and prolonged latency on midline and bilateral temporal-posterior scalp areas. Shared genetic factors were the main source of these associations. Conclusions: The results confirm that MMN is not an endophenotype for psychotic BPD whereas P300 amplitude and latency components are valid endophenotypes for psychotic BPD.

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Crossref · 10.1017/s0033291709005261

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Authors
Hall, M.-H., Schulze, K., Rijsdijk, F., Kalidindi, S., McDonald, C., Bramon, E., Murray, R. M., & Sham, P.
Affiliations
  • Harvard University (US)
  • King's College London (GB)
  • National University of Ireland (IE)
  • University of Hong Kong (HK)
Corresponding author
Hall, M.-H.
Venue
Psychological Medicine
Published
2009-03-02
Volume
39
Issue
8
Pages
1277-1287
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
OpenAlex
W2015772384
Cited by
117
References
42
Citations by year
2025: 1 · 2024: 6 · 2023: 2 · 2022: 8 · 2021: 4 · 2020: 5 · 2019: 20 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 5 · 2014: 10 · 2013: 11 · 2012: 10
FWCI
5.57
Type
journal article
Language
en
Open access
closed
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
  • Wellcome Trust
  • National Institute for Health and Care Research (PDA/02/06/016)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
psychotic bipolar disorder, P300, mismatch negativity, endophenotypes, heritability, genetic overlap, P300 amplitude, P300 latency, twin studies
MeSH terms
Acoustic Stimulation, Adult, Bipolar Disorder, Cerebral Cortex, Contingent Negative Variation, Diseases in Twins, Dominance, Cerebral, Electrocardiography, England, Evoked Potentials, Auditory, Female, Humans, Male, Middle Aged, Models, Genetic, Phenotype, Psychiatric Status Rating Scales, Reaction Time, Signal Processing, Computer-Assisted, Social Environment, Statistics as Topic, Twins, Dizygotic, Twins, Monozygotic, Cohort Studies, Event-Related Potentials, P300

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