Alpha Asymmetry in Infants at Risk for Autism Spectrum Disorders
Open accessAbstract
An emerging focus of research on autism spectrum disorder (ASD) targets the identification of early-developing ASD endophenotypes using infant siblings of affected children. One potential neural endophenotype is resting frontal electroencephalogram (EEG) alpha asymmetry, a metric of hemispheric organization. Here, we examined the development of frontal EEG alpha asymmetry in ASD high-risk and low-risk infant populations. Our findings demonstrate that low and high-risk infants show different patterns of alpha asymmetry at 6 months of age and opposite growth trajectories in asymmetry over the following 12 months. These results support the candidacy of alpha asymmetry as an early neural ASD endophenotype.
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Infants at high risk for ASD, regardless of whether they ultimately meet diagnostic criteria for ASD, have different developmental trajectories within the first year of life compared to low-risk infants.
“There is now accumulating evidence from electroencephalographic (EEG) studies suggesting that infants at high risk for ASD, regardless of whether they ultimately meet diagnostic criteria for ASD, have different developmental trajectories within the first year of life compared to low-risk infants [10–20].”
From EEG power at 3 months in infants at high familial risk for autism (2017) · cites this paper as [12]
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Research works printed but not linked: 1
- Singer J Willett J Applied Longitudinal Data Analysis New York Oxford University Press 2003
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Developmental Trajectories of Resting EEG Power: An Endophenotype of Autism Spectrum Disorder
Tierney, A. L., Gabard-Durnam, L., Vogel-Farley, V., Tager-Flusberg, H., & Nelson, C. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039127 · Cited by 226 · see citing works
Self-citationEEG power at 3 months in infants at high familial risk for autism
Levin, A. R., Varcin, K. J., O’Leary, H. M., Tager-Flusberg, H., & Nelson, C. A. (2017) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-017-9214-9 · Cited by 107 · see citing works
Self-citationRighi, G., Tierney, A. L., Tager-Flusberg, H., & Nelson, C. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105176 · Cited by 105 · see citing works
“The present results are consistent with a growing body of literature showing the emergence of risk-related differences in electrophysiological responses that emerge over the course of the first year of life [16,37,38].”
ResultSelf-citation
- Authors
- Gabard-Durnam, L., Tierney, A. L., Vogel-Farley, V., Tager-Flusberg, H., & Nelson, C. A.
- Affiliations
- University of California, Los Angeles (US)
- Boston Children's Hospital (US)
- Boston University (US)
- Corresponding author
- Nelson, Charles A.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2013-08-30
- Volume
- 45
- Issue
- 2
- Pages
- 473-480
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC3938993
- OpenAlex
- W1981271949
- Cited by
- 85
- References
- 46
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 4 · 2021: 9 · 2020: 7 · 2019: 10 · 2018: 4 · 2017: 10 · 2016: 6 · 2015: 4 · 2014: 3 · 2012: 1
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Autism Speaks
- Simons Foundation
- National Institute on Deafness and Other Communication Disorders (R01 DC10290, R21 DC 08637, R01DC010290, R21DC008637)
- National Center for Research Resources (M01RR002172)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD018655)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, alpha asymmetry, frontal EEG, endophenotypes, infant siblings, high-risk infants, hemispheric organization, developmental trajectories
- MeSH terms
- Age Factors, Alpha Rhythm, Child Development Disorders, Pervasive, Dominance, Cerebral, Electroencephalography, Female, Frontal Lobe, Humans, Infant, Male, Siblings, Endophenotypes, Prodromal Symptoms
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