Cited by 191Stress Responses and CortisolAdrenal Hormones and DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Not fade away: the HPA axis and depression

Open access
Cowen, P. J.·2010·Psychological Medicine

Abstract

Salivary cortisol sampling has confirmed the presence of increased cortisol secretion in depression and has also revealed that some aspects of hypothalamo-pituitary-adrenal (HPA) axis disturbance have trait-like characteristics that may predict the risk of future illness. Persistent hypersecretion of cortisol in individuals vulnerable to depression also has implications for the medical co-morbidities associated with mood disorder. Pharmacological treatments targeted at the HPA axis represent a novel approach to the management of depression and its complications; however, a better understanding of the molecular basis of HPA axis dysfunction in depressed patients will be needed before this promise can be fulfilled.

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Crossref · 10.1017/s0033291709005558

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21 of 21 references verified0 citation errors · 0 not checkable

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Authors
Cowen, P. J.
Affiliations
Warneford Hospital (GB)
Corresponding author
Cowen, P. J.
Venue
Psychological Medicine
Published
2009-04-01
Volume
40
Issue
1
Pages
1-4
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
OpenAlex
W2124814518
Cited by
191
References
22
Citations by year
2026: 1 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 28 · 2020: 5 · 2019: 13 · 2018: 15 · 2017: 7 · 2016: 5 · 2015: 9 · 2014: 16 · 2013: 19 · 2012: 20
FWCI
6.13
Type
journal article
Language
en
Open access
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Medical Research Council
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
hypothalamic-pituitary-adrenal axis, depression, salivary cortisol, cortisol hypersecretion, depression risk prediction, comorbidities, mood disorders, HPA axis dysregulation
MeSH terms
Affect, Antidepressive Agents, Circadian Rhythm, Depressive Disorder, Major, Major Depressive Disorder, Dexamethasone, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Prognosis, Saliva, Comorbidity

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