Cited by 191Stress Responses and CortisolAdrenal Hormones and DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Not fade away: the HPA axis and depression

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Cowen, P. J.·2010·Psychological Medicine

DOI 10.1017/s0033291709005558

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Abstract

Salivary cortisol sampling has confirmed the presence of increased cortisol secretion in depression and has also revealed that some aspects of hypothalamo-pituitary-adrenal (HPA) axis disturbance have trait-like characteristics that may predict the risk of future illness. Persistent hypersecretion of cortisol in individuals vulnerable to depression also has implications for the medical co-morbidities associated with mood disorder. Pharmacological treatments targeted at the HPA axis represent a novel approach to the management of depression and its complications; however, a better understanding of the molecular basis of HPA axis dysfunction in depressed patients will be needed before this promise can be fulfilled.

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Authors: Cowen, P. J.
Affiliations: Warneford Hospital (GB)
Corresponding author: Cowen, P. J.
ORCID: Cowen, P. J.
Venue: Psychological Medicine
Publisher: Cambridge University Press (CUP)
Published: 2009-04-01
Volume: 40
Issue: 1
Pages: 1-4
ISSN: 0033-2917 (ISSN-L)
1469-8978
DOI: 10.1017/s0033291709005558
OpenAlex: W2124814518
Cited by: 191
References: 22
Citations by year: 2026: 1 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 28 · 2020: 5 · 2019: 13 · 2018: 15 · 2017: 7 · 2016: 5 · 2015: 9 · 2014: 16 · 2013: 19 · 2012: 20
FWCI: 6.13
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Psychological Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: hypothalamic-pituitary-adrenal axis, depression, salivary cortisol, cortisol hypersecretion, depression risk prediction, comorbidities, mood disorders, HPA axis dysregulation
MeSH terms: Affect, Antidepressive Agents, Circadian Rhythm, Depressive Disorder, Major, Major Depressive Disorder, Dexamethasone, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Prognosis, Saliva, Comorbidity

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Not fade away: the HPA axis and depression

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