The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder
Open accessAbstract
Background: Recent meta-analyses of resting-state networks in major depressive disorder (MDD) implicate network disruptions underlying cognitive and affective features of illness. Heterogeneity of findings to date may stem from the relative lack of data parsing clinical features of MDD such as phase of illness and the burden of multiple episodes. Method: Resting-state functional magnetic resonance imaging data were collected from 17 active MDD and 34 remitted MDD patients, and 26 healthy controls (HCs) across two sites. Participants were medication-free and further subdivided into those with single v.multiple episodes to examine disease burden. Seed-based connectivity using the posterior cingulate cortex (PCC) seed to probe the default mode network as well as the amygdala and subgenual anterior cingulate cortex (sgACC) seeds to probe the salience network (SN) were conducted. Results: Young adults with remitted MDD demonstrated hyperconnectivity of the left PCC to the left inferior frontal gyrus and of the left sgACC to the right ventromedial prefrontal cortex (PFC) and left hippocampus compared with HCs. Episode-independent effects were observed between the left PCC and the right dorsolateral PFC, as well as between the left amygdala and right insula and caudate, whereas the burden of multiple episodes was associated with hypoconnectivity of the left PCC to multiple cognitive control regions as well as hypoconnectivity of the amygdala to large portions of the SN. Conclusions: This is the first study of a homogeneous sample of unmedicated young adults with a history of adolescent-onset MDD illustrating brain-based episodic features of illness.
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“Second, the evidence in favour of abnormal RSFC of the sgACC, on which we based our hypotheses and analyses, is admittedly heterogeneous and also does rely on partially overlapping samples15,19–21.”
From The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse (2020) · cites this paper as [20]
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“Dysfunction in the SN contributes to biases in emotion processing and autonomic regulation (Drevets et al. 2008; Briceño et al. 2013; for a review, see Price & Drevets, 2010).”
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Brain structure alterations in depression: Psychoradiological evidence
Zhang, F., Peng, W. J., Sweeney, J. A., Jia, Z., & Gong, Q. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12835 · Cited by 507
Tang, S., Lu, L., Zhang, L., Hu, X., Bu, X., Li, H., Hu, X., Gao, Y., Zeng, Z., Gong, Q., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.010 · Cited by 187
Connolly, C. G., Ho, T. C., Blom, E. H., LeWinn, K. Z., Sacchet, M. D., Tymofiyeva, O., Simmons, A. N., & Yang, T. T. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.09.026 · Cited by 177
Role of inflammation in depression relapse
Liu, C., Zhang, G., Li, B., Li, M., Woelfer, M., Walter, M., & Wang, L. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1475-7 · Cited by 170
Jiao, W., Lin, J., Deng, Y., Ji, Y., Liang, C., Wei, S., Xi, J., & Yan, F. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03312-3 · Cited by 132
Metadata
- Authors
- Jacobs, R. H., Barba, A., Gowins, J. R., Klumpp, H., Jenkins, L. M., Mickey, B. J., Ajilore, O., Peciña, M., Sikora, M., Ryan, K. A., Hsu, D. T., Welsh, R. C., Zubieta, J.-K., Phan, K. L., & Langenecker, S. A.
- Affiliations
- University of Illinois Chicago (US)
- University of Michigan (US)
- Corresponding author
- Langenecker, S. A.
- ORCID
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2016-01-20
- Volume
- 46
- Issue
- 5
- Pages
- 1055-1067
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC4810773
- OpenAlex
- W2262083186
- Cited by
- 108
- References
- 44
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 35 · 2020: 9 · 2019: 8 · 2018: 11 · 2017: 6 · 2016: 5
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000050, 5r01ns052514-04, KL2TR000434)
- National Institute of Mental Health (R01MH091811, K01MH085035, R01MH101497, K23MH092648, R01MH086858, K23MH093679, R01MH101487)
- National Institute of Neurological Disorders and Stroke (1R01NS052514, R01-NS052514)
- National Center for Advancing Translational Sciences (UL1TR00050)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- recurrent major depressive disorder, adolescent-onset depression, salience network, amygdala, default mode network, posterior cingulate cortex, subgenual anterior cingulate cortex, resting-state functional connectivity, remitted depression, cognitive control, young adults
- MeSH terms
- Adolescent, Adult, Amygdala, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, Female, Frontal Lobe, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Recurrence, Case-Control Studies, Young Adult, Executive Function
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