Cited by 220Schizophrenia research and treatmentDementia and Cognitive Impairment ResearchMental Health and Psychiatry

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The relationship between cognitive impairment in schizophrenia and metabolic syndrome: a systematic review and meta-analysis

Bora, E., Akdede, B. B., Alptekin, K.·2017·Psychological Medicine

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Abstract

Background: Individuals with schizophrenia are at greater risk for metabolic syndrome (MetS) which is associated with cognitive deficits in the general population. MetS might be potentially an important contributing factor to cognitive impairment in schizophrenia. Method: In the current systematic review and meta-analysis, the findings of 18 studies investigating the association between MetS (and its components) with cognitive impairment in schizophrenia are reviewed. Results: Co-morbidity of MetS ( d = 0.28) and diabetes mellitus ( d = 0.28) were both associated with more severe cognitive deficits in schizophrenia. There was also evidence for a significant relationship between cognitive impairment in schizophrenia and each of the components of MetS including hypertension, dyslipidemia, abdominal obesity and diabetes. Conclusions: MetS is significantly associated with cognitive impairment in schizophrenia and can potentially contribute to functional decline observed in some patients with schizophrenia throughout the course of illness.

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Authors: Bora, E., Akdede, B. B., & Alptekin, K.
Affiliations: The University of Melbourne (AU)
Dokuz Eylül University (TR)
Corresponding author: Bora, E.
ORCID: Bora, E.
Akdede, B. B.
Venue: Psychological Medicine
Publisher: Cambridge University Press (CUP)
Published: 2016-12-29
Volume: 47
Issue: 6
Pages: 1030-1040
ISSN: 0033-2917 (ISSN-L)
1469-8978
DOI: 10.1017/s0033291716003366
OpenAlex: W2563404365
Cited by: 219
References: 56
Citations by year: 2026: 11 · 2025: 23 · 2024: 29 · 2023: 22 · 2022: 34 · 2021: 28 · 2020: 24 · 2019: 23 · 2018: 15 · 2017: 9
FWCI: 2.24
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Psychological Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: schizophrenia, cognitive impairment, metabolic syndrome, diabetes mellitus, hypertension, dyslipidemia, abdominal obesity, functional decline, comorbidities
MeSH terms: Diabetes Mellitus, Humans, Schizophrenia, Comorbidity, Metabolic Syndrome, Cognitive Dysfunction

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The relationship between cognitive impairment in schizophrenia and metabolic syndrome: a systematic review and meta-analysis

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