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The relationship between cognitive impairment in schizophrenia and metabolic syndrome: a systematic review and meta-analysis
Abstract
Background: Individuals with schizophrenia are at greater risk for metabolic syndrome (MetS) which is associated with cognitive deficits in the general population. MetS might be potentially an important contributing factor to cognitive impairment in schizophrenia. Method: In the current systematic review and meta-analysis, the findings of 18 studies investigating the association between MetS (and its components) with cognitive impairment in schizophrenia are reviewed. Results: Co-morbidity of MetS ( d = 0.28) and diabetes mellitus ( d = 0.28) were both associated with more severe cognitive deficits in schizophrenia. There was also evidence for a significant relationship between cognitive impairment in schizophrenia and each of the components of MetS including hypertension, dyslipidemia, abdominal obesity and diabetes. Conclusions: MetS is significantly associated with cognitive impairment in schizophrenia and can potentially contribute to functional decline observed in some patients with schizophrenia throughout the course of illness.
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“Moreover, increased cardio-metabolic dysfunction has been associated with worse mental and cognitive symptoms in those with schizophrenia [98], MDD [99], bipolar disorder [100] and binge eating disorder [101].”
From Exercise as Medicine for Mental and Substance Use Disorders: A Meta-review of the Benefits for Neuropsychiatric and Cognitive Outcomes (2020) · cites this paper as [98]
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Metadata
- Authors
- Bora, E., Akdede, B. B., & Alptekin, K.
- Affiliations
- The University of Melbourne (AU)
- Dokuz Eylül University (TR)
- Corresponding author
- Bora, E.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2016-12-29
- Volume
- 47
- Issue
- 6
- Pages
- 1030-1040
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2563404365
- Cited by
- 219
- References
- 56
- Citations by year
- 2026: 11 · 2025: 23 · 2024: 29 · 2023: 22 · 2022: 34 · 2021: 28 · 2020: 24 · 2019: 23 · 2018: 15 · 2017: 9
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, cognitive impairment, metabolic syndrome, diabetes mellitus, hypertension, dyslipidemia, abdominal obesity, functional decline, comorbidities
- MeSH terms
- Diabetes Mellitus, Humans, Schizophrenia, Comorbidity, Metabolic Syndrome, Cognitive Dysfunction
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