Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls

Pettersson, E.; Lichtenstein, P.; Larsson, H.; Song, J.; Attention Deficit/Hyperactivity Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Autism Spectrum Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Bipolar Disorder Working Group of the PGC, Eating Disorder Working Group of the PGC, Major Depressive Disorder Working Group of the PGC, Obsessive Compulsive Disorders and Tourette Syndrome Working Group of the PGC, Schizophrenia CLOZUK, Substance Use Disorder Working Group of the PGC; Agrawal, A.; Børglum, A. D.; Bulik, C. M.; Daly, M. J.; Davis, L. K.; Demontis, D.; Edenberg, H. J.; Grove, J.; Gelernter, J.; Neale, B. M.; Pardiñas, A. F.; Stahl, E.; Walters, J. T. R.; Walters, R.; Sullivan, P. F.; Posthuma, D.; Polderman, T. J. C.

doi:10.1017/s0033291718002039

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls

Background Most studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent assumptions, strengths, and biases. We aim to test the homo…