Prevalence of suicide attempt in individuals with major depressive disorder: a meta-analysis of observational surveys
Abstract
Background: Suicide attempt (SA), which is one of the strongest predictors of completed suicide, is common in major depressive disorder (MDD) but its prevalence across epidemiological studies has been mixed. The aim of this comprehensive meta-analysis was to examine the pooled prevalence of SA in individuals with MDD. Methods: A systematic literature search was conducted in PubMed, Embase, PsycINFO, Web of Science and Cochrane Library from their commencement date until 27 December 2017. Original studies containing data on prevalence of SA in individuals with MDD were analyzed. Results: In all, 65 studies with a total of 27 340 individuals with MDD were included. Using the random effects model, the pooled lifetime prevalence of SA was 31% [95% confidence interval (CI) 27–34%], 1-year prevalence was 8% (95% CI 3–14%) and 1-month prevalence was 24% (95% CI 15–34%). Subgroup analyses revealed that the lifetime prevalence of SA was significantly associated with the patient setting, study region and income level, while the 1-month prevalence of SA was associated with only the patient setting. Conclusion: This meta-analysis confirmed that SA was common in individuals with MDD across the world. Careful screening and appropriate interventions should be implemented for SA in the MDD population.
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Comorbid anxiety and/or substance use disorders are found among most people diagnosed with depression, both in community epidemiological surveys and in studies of primary care or specialized care settings.
“Comorbid anxiety and/or substance use disorders are found among most people diagnosed with depression, both in community epidemiological surveys 174 and in studies of primary care 175 or specialized care settings. 176”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [176]
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- Authors
- Dong, M., Zeng, L.-N., Lu, L., Li, X.-H., Ungvari, G. S., Ng, C. H., Chow, I. H. I., Zhang, L., Zhou, Y., & Xiang, Y.-T.
- Affiliations
- University of Macau (MO)
- The University of Notre Dame Australia (AU)
- The University of Melbourne (AU)
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Xiang, Yu-Tao
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2018-09-04
- Volume
- 49
- Issue
- 10
- Pages
- 1691-1704
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2891384565
- Cited by
- 263
- References
- 133
- Citations by year
- 2026: 29 · 2025: 44 · 2024: 58 · 2023: 45 · 2022: 39 · 2021: 26 · 2020: 15 · 2019: 5 · 2018: 1 · 2013: 1
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Sociology and Political Science › Homicide, Infanticide, and Child Abuse
- Keywords
- suicide attempts, major depressive disorder, prevalence, lifetime prevalence, suicide risk, suicide risk screening
- MeSH terms
- Adult, Major Depressive Disorder, Humans, Middle Aged, Suicide, Attempted, Prevalence, Young Adult, Observational Studies as Topic
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