Corpus callosum integrity is affected by mood disorders and also by the suicide attempt history: A diffusion tensor imaging study
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Background Some MRI studies have noted alterations in the corpus callosum (CC) white matter integrity of individuals with mood disorders and also in patients with suicidal behavior. We investigated the specific impact of suicidal behavior on CC integrity in mood disorders.Methods CC structural changes were assessed by diffusion tensor imaging (DTI) in 121 women 18-50-year-old): 41 with bipolar disorder (BD), 50 with major depressive disorder (MDD) and 30 healthy controls (HC). Fractional anisotropy (FA) and DTI metrics were calculated for the genu, body and splenium of CC and compared in the three groups by MANCOVA. Then, they were re-analyzed relative to the suicide attempt history within the MDD and BD groups and to the suicide number/severity.Results FA values for the CC genu and body were lower in non-suicide attempters with BD than with MDD and in HC. Conversely, FA values for all CC regions were significantly lower in suicide attempters with BD than in HC. Finally, higher number of suicide attempts (>2) and elevated Suicidal Intent Scale score were associated with significant splenium alterations.Limitations Limitations include the cross-sectional design (non-causal study), the potential influence of medications and concerns about the generalizability to men.Conclusion Genu and body are altered in non-suicide attempters with BD, while splenium is specifically altered in suicide attempters, independently from their psychiatric status. History of suicide attempts may be a source of heterogeneity in the association between CC alterations and BD and may partially explain the variable results of previous studies.
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Lower frontal-subcortical fractional anisotropy may indicate impaired top-down executive control, explaining correlations with attempt-related impulsivity and number of suicide attempts.
“Such findings may indicate impaired top-down executive control, explaining a correlation with attempt-related impulsivity (80) and number of suicide attempts (81, 82).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [81]
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- Authors
- Cyprien, F., de Champfleur, N. M., Deverdun, J., Olié, E., Le Bars, E., Bonafé, A., Mura, T., Jollant, F., Courtet, P., & Artero, S.
- Affiliations
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- Université de Montpellier (FR)
- Douglas Mental Health University Institute (CA)
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 206
- Pages
- 115-124
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2505695543
- Cited by
- 50
- References
- 51
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 1
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- green
- hal.umontpellier.fr
- Licence
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Keywords
- corpus callosum, white matter integrity, mood disorders, bipolar disorder, major depressive disorder, suicide attempt history, fractional anisotropy, corpus callosum genu, splenium of corpus callosum, suicidal behavior, women
- MeSH terms
- Adult, Bipolar Disorder, Corpus Callosum, Cross-Sectional Studies, Major Depressive Disorder, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Middle Aged, Suicide, Attempted, Case-Control Studies, Anisotropy, Mood Disorders, Young Adult, Diffusion Tensor Imaging, White Matter
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