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Cited by 449Schizophrenia research and treatmentMental Health and PsychiatryNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 608 of the 608 references it cites were found in a registry or an index.

Convergence of biological and psychological perspectives on cognitive coordination in schizophrenia

Phillips, William A., Silverstein, Steven M.·2003·Behavioral and Brain Sciences
DOI 10.1017/s0140525x03000025
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Abstract

The concept of locally specialized functions dominates research on higher brain function and its disorders. Locally specialized functions must be complemented by processes that coordinate those functions, however, and impairment of coordinating processes may be central to some psychotic conditions. Evidence for processes that coordinate activity is provided by neurobiological and psychological studies of contextual disambiguation and dynamic grouping. Mechanisms by which this important class of cognitive functions could be achieved include those long-range connections within and between cortical regions that activate synaptic channels via NMDA-receptors, and which control gain through their voltage-dependent mode of operation. An impairment of these mechanisms is central to PCP-psychosis, and the cognitive capabilities that they could provide are impaired in some forms of schizophrenia. We conclude that impaired cognitive coordination due to reduced ion flow through NMDA-channels is involved in schizophrenia, and we suggest that it may also be involved in other disorders. This perspective suggests several ways in which further research could enhance our understanding of cognitive coordination, its neural basis, and its relevance to psychopathology.

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Metadata

Authors
Phillips, W. A., & Silverstein, S. M.
Affiliations
  • University of Stirling (GB)
  • Cornell University (US)
ORCID
Venue
Behavioral and Brain Sciences
Publisher
Cambridge University Press (CUP)
Published
2003-02
Volume
26
Issue
1
Pages
65-82
ISSN
  • 0140-525X (ISSN-L)
  • 1469-1825
DOI
10.1017/s0140525x03000025
OpenAlex
W2136592274
Semantic Scholar
73a193e6ab4240fb5b616a3af2a1ff375857ca05
Cited by
445
References
607
Citations by year
2026: 6 · 2025: 2 · 2024: 3 · 2023: 25 · 2022: 9 · 2021: 17 · 2020: 6 · 2019: 15 · 2018: 20 · 2017: 23 · 2016: 23 · 2015: 27 · 2014: 22 · 2013: 30 · 2012: 20
FWCI
3.28
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified, 214 d)
Locations
  • Behavioral and Brain Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Stirling Online Research Repository (University of Stirling) (submittedVersion, public-domain)
Funders
  • American Psychological Association
  • McGill University
  • National Alliance for Research on Schizophrenia and Depression
  • Canada Research Chairs
  • VA Pittsburgh Healthcare System
  • Canadian Institutes of Health Research
  • Natural Sciences and Engineering Research Council of Canada
  • National Institute of Mental Health
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
schizophrenia, cognitive coordination, dynamic grouping, NMDA receptor, long-range cortical connections, psychosis, neural basis of cognition
MeSH terms
Cerebral Cortex, Cognition, Cognition Disorders, Humans, Mental Processes, Models, Neurological, Models, Psychological, Nerve Net, Schizophrenia, Schizophrenic Psychology, Receptors, N-Methyl-D-Aspartate

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