Converging evidence for brain stem injury in autism
Abstract
The hypothesis that brain stem injury plays a role in the autism spectrum disorders was suggested by evidence that exposure to thalidomide during the earliest stages of brain development increases the risk of autism spectrum disorders. The implications for the embryological origin of autism first led to studies of neuroanatomy in a human case and an animal model and then to examinations of minor craniofacial features in autism. But the general hypothesis had much broader implications. It has now generated studies of the behavioral and neurological symptoms of human patients, of human molecular genetics and population genetics, and of animal behavioral teratology and molecular pharmacology. The collection of this range of data was made possible by adding experts from many fields to the research team. They worked both independently and collaboratively to try to unravel the etiology of autism.
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In both TDC and ASD, DC showed positive relationships with regions implicated in cognitive control.
“In both TDC and ASD, DC showed positive relationships with regions implicated in cognitive control (63-65)”
From Aberrant Striatal Functional Connectivity in Children with Autism (2011) · cites this paper as [65]
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- Authors
- RODIER, P. M.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- RODIER, PATRICIA M.
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2002-08-20
- Volume
- 14
- Issue
- 3
- Pages
- 537-557
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- OpenAlex
- W2023965963
- Cited by
- 104
- References
- 3
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 10
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hd034969-04, 5r01hd034295-05)
- National Institute of Environmental Health Sciences (ES-01247, P30ES001247)
- National Center for Research Resources (RR-00044, M01RR000044)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD34969, HD35466, HD34295)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- autism spectrum disorder, brainstem injury, thalidomide, craniofacial features, molecular pharmacology, autism etiology, neuroanatomy, molecular genetics, population genetics
- MeSH terms
- Homeobox A1 Protein, Autistic Disorder, Brain Stem, Child, Humans, Hypnotics and Sedatives, Molecular Biology, Thalidomide, Transcription Factors, Polymerase Chain Reaction, Homeodomain Proteins, Genetic Predisposition to Disease
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