Reorganization of Circuits Underlying Cerebellar Modulation of Prefrontal Cortical Dopamine in Mouse Models of Autism Spectrum Disorder
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Imaging, clinical, and pre-clinical studies have provided ample evidence for a cerebellar involvement in cognitive brain function including cognitive brain disorders, such as autism and schizophrenia. We previously reported that cerebellar activity modulates dopamine release in the mouse medial prefrontal cortex (mPFC) via two distinct pathways: (1) cerebellum to mPFC via dopaminergic projections from the ventral tegmental area (VTA) and (2) cerebellum to mPFC via glutamatergic projections from the mediodorsal and ventrolateral thalamus (ThN md and vl). The present study compared functional adaptations of cerebello-cortical circuitry following developmental cerebellar pathology in a mouse model of developmental loss of Purkinje cells (Lurcher) and a mouse model of fragile X syndrome (Fmr1 KO mice). Fixed potential amperometry was used to measure mPFC dopamine release in response to cerebellar electrical stimulation. Mutant mice of both strains showed an attenuation in cerebellar-evoked mPFC dopamine release compared to respective wildtype mice. This was accompanied by a functional reorganization of the VTA and thalamic pathways mediating cerebellar modulation of mPFC dopamine release. Inactivation of the VTA pathway by intra-VTA lidocaine or kynurenate infusions decreased dopamine release by 50 % in wildtype and 20-30 % in mutant mice of both strains. Intra-ThN vl infusions of either drug decreased dopamine release by 15 % in wildtype and 40 % in mutant mice of both strains, while dopamine release remained relatively unchanged following intra-ThN md drug infusions. These results indicate a shift in strength towards the thalamic vl projection, away from the VTA. Thus, cerebellar neuropathologies associated with autism spectrum disorders may cause a reduction in cerebellar modulation of mPFC dopamine release that is related to a reorganization of the mediating neuronal pathways.
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Changes in cerebellar-mPFC functional connectivity have been identified in mouse models of cerebellar PC loss and in genetic mouse models of ASD.
“in mouse models of cerebellar PC loss, and in genetic mouse models of ASD17,18.”
From Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits (2020) · cites this paper as [18]
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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M. F., Zhang, F., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90397-h · Cited by 3,481 · see citing works
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · see citing works
Muhle, R., Trentacoste, S. V., & Rapin, I. (2004) · Pediatrics · doi:10.1542/peds.113.5.e472 · Cited by 1,207 · see citing works
A clinicopathological study of autism
Bailey, A. (1998) · Brain · doi:10.1093/brain/121.5.889 · Cited by 1,083 · see citing works
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,075 · see citing works
Hypoplasia of cerebellar vermal lobules VI and VII in autism
Courchesne, E., Yeung-Courchesne, R., Hesselink, J. R., & Jernigan, T. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805263182102 · Cited by 1,058 · see citing works
Cerebellar Projections to the Prefrontal Cortex of the Primate
Middleton, F. A., & Strick, P. L. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00700.2001 · Cited by 1,034 · see citing works
Neuroanatomic observations of the brain in autism: a review and future directions
Bauman, M. L., & Kemper, T. L. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.09.006 · Cited by 919 · see citing works
Impairment in shifting attention in autistic and cerebellar patients.
Courchesne, E., Townsend, J., Akshoomoff, N. A., Saitoh, O., Yeung-Courchesne, R., Lincoln, A. J., James, H. E., Haas, R., Schreibman, L., & Lau, L. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.5.848 · Cited by 647 · see citing works
Impairment in shifting attention in autistic and cerebellar patients
Courchesne, E., Townsend, J., Akshoomoff, N. A., Saitoh, O., Yeung-Courchesne, R., Lincoln, A. J., James, H. E., Haas, R. H., Schreibman, L., & Lau, L. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.5.848 · Cited by 647 · see citing works
(1994) · PubMed · Cited by 565 · see citing works
A clinical study of 57 children with fetal anticonvulsant syndromes
Moore, S. J., Turnpenny, P., Quinn, A., Glover, S., Lloyd, D. J., Montgomery, T., & Dean, J. C. S. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.7.489 · Cited by 562 · see citing works
Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene
Zuo, J., De Jager, P. L., Takahashi, K. A., Jiang, W., Linden, D. J., & Heintz, N. (1997) · Nature · doi:10.1038/42009 · Cited by 554 · see citing works
Genetic architecture in autism spectrum disorder
Devlin, B., & Scherer, S. W. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.03.002 · Cited by 545 · see citing works
Neuropathological findings in autism
Palmen, S. J. M. C. (2004) · Brain · doi:10.1093/brain/awh287 · Cited by 527 · see citing works
Structural and quantitative studies on the normal C3H and lurcher mutant mouse
Caddy, K. W. T., & Biscoe, T. J. (1979) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1979.0055 · Cited by 484 · see citing works
Localized enlargement of the frontal cortex in early autism
Carper, R. A., & Courchesne, E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.005 · Cited by 456 · see citing works
The developmental neurobiology of autism spectrum disorder
DiCicco-Bloom, E., Lord, C., Zwaigenbaum, L., Courchesne, E., Dager, S. R., Schmitz, C., Schultz, R. T., Crawley, J., & Young, L. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1712-06.2006 · Cited by 434 · see citing works
Koekkoek, S. K. E., Yamaguchi, K., Milojkovic, B. A., Dortland, B. R., Ruigrok, T. J. H., Maex, R., Graaf, W. D., Smit, A. E., VanderWerf, F., Bakker, C. E., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.005 · Cited by 417 · see citing works
Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism
Courchesne, E. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80016-5 · Cited by 401 · see citing works
Inverse correlation between frontal lobe and cerebellum sizes in children with autism
Carper, R. A. (2000) · Brain · doi:10.1093/brain/123.4.836 · Cited by 333 · see citing works
Aalto, S., Brück, A., Laine, M., Någren, K., & Rinne, J. O. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2097-04.2005 · Cited by 284 · see citing works
Cerebellar pathways to ventral midbrain and nigra
Snider, R. S., Maiti, A. K., & Snider, S. R. (1976) · Experimental Neurology · doi:10.1016/0014-4886(76)90150-3 · Cited by 248 · see citing works
Low medial prefrontal dopaminergic activity in autistic children
Ernst, M., Zametkin, A., Matochik, J., Pascualvaca, D., & Cohen, R. (1997) · The Lancet · doi:10.1016/s0140-6736(05)63326-0 · Cited by 246 · see citing works
Microscopic Neuroanatomic Abnormalities in Autism
Bauman, M. L. (1991) · Pediatrics · doi:10.1542/peds.87.5.791 · Cited by 242 · see citing works
Gamo, N. J., Wang, M., & Arnsten, A. F. T. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.06.015 · Cited by 232 · see citing works
Kumar, A., Sundaram, S. K., Sivaswamy, L., Behen, M. E., Makki, M., Ager, J. W., Janisse, J. J., Chugani, H. T., & Chugani, D. C. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp278 · Cited by 211 · see citing works
Mildly impaired water maze performance in maleFmr1 knockout mice
D'Hooge, R., Nagels, G., Franck, F., Bakker, C. E., Reyniers, E., Storm, K., Kooy, R. F., Oostra, B. A., Willems, P. J., & De Deyn, P. P. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00224-2 · Cited by 208 · see citing works
Reduced thalamic volume in high-functioning individuals with autism
Tsatsanis, K., Rourke, B. P., Klin, A., Volkmar, F. R., Cicchetti, D. V., & Schultz, R. T. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01530-5 · Cited by 180 · see citing works
Forster, G. L., & Blaha, C. D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02511.x · Cited by 175 · see citing works
Self-citationBasal ganglia morphometry and repetitive behavior in young children with autism spectrum disorder
Estes, A. M., Shaw, D., Sparks, B. F., Friedman, S. D., Giedd, J. N., Dawson, G., Bryan, M. J., & Dager, S. R. (2011) · Autism Research · doi:10.1002/aur.193 · Cited by 172 · see citing works
Cerebellar vermal volumes and behavioral correlates in children with autism spectrum disorder
Webb, S. J., Sparks, B. F., Friedman, S. D., Shaw, D., Giedd, J. N., Dawson, G., & Dager, S. R. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2008.06.001 · Cited by 154 · see citing works
Pinto, A., Jankowski, M. P., & Sesack, S. R. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10596 · Cited by 130 · see citing works
Knockout mouse model for Fxr2: a model for mental retardation
Bontekoe, C. J. M. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.5.487 · Cited by 120 · see citing works
Rogers, T. D., Dickson, P. E., Heck, D. H., Goldowitz, D., Mittleman, G., & Blaha, C. D. (2011) · Synapse · doi:10.1002/syn.20960 · Cited by 120 · see citing works
Self-citationAutism and Möbius sequence: an exploratory study of children in northeastern Brazil
Bandim, J. M., Ventura, L. O., Miller, M. T., de Almeida, H. C., & Costa, A. E. S. (2003) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2003000200004 · Cited by 116 · see citing works
Mittleman, G., Goldowitz, D., Heck, D. H., & Blaha, C. D. (2008) · Synapse · doi:10.1002/syn.20525 · Cited by 111 · see citing works
Self-citationAnatomical phenotyping in a mouse model of fragile X syndrome with magnetic resonance imaging
Ellegood, J., Pacey, L. K. K., Hampson, D. R., Lerch, J. P., & Henkelman, R. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.03.038 · Cited by 110 · see citing works
Yu, K., Cheung, C., Chua, S. E., & McAlonan, G. M. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100138 · Cited by 107 · see citing works
Cerebellar and cerebral abnormalities in Rett syndrome: a quantitative MR analysis.
Murakami, J. W., Courchesne, E., Haas, R., Press, G. A., & Yeung-Courchesne, R. (1992) · American Journal of Roentgenology · doi:10.2214/ajr.159.1.1609693 · Cited by 106 · see citing works
Converging evidence for brain stem injury in autism
RODIER, P. M. (2002) · Development and Psychopathology · doi:10.1017/s0954579402003085 · Cited by 104 · see citing works
Techniques for the Genetic Analysis of Brain and Behavior: Focus on the Mouse
Goldowitz, D., Wahłsten, D., & Wimer, R. E. (1992) · Medical Entomology and Zoology · Cited by 103 · see citing works
Self-citationBrain morphometry volume in autistic spectrum disorder: a magnetic resonance imaging study of adults
Hallahan, B., Daly, E. M., McAlonan, G., Loth, E., Toal, F., O'Brien, F., Robertson, D., Hales, S., Murphy, C., Murphy, K. C., et al. (2009) · Psychological Medicine · doi:10.1017/s0033291708003383 · Cited by 94 · see citing works
Right-Hemisphere Dysfunction in Asperger's Syndrome
McKelvey, J. R., Lambert, R., Mottron, L., & Shevell, M. I. (1995) · Journal of Child Neurology · doi:10.1177/088307389501000413 · Cited by 91 · see citing works
Greco, C. M., Navarro, C. S., Hunsaker, M. R., Maezawa, I., Shuler, J. F., Tassone, F., Delany, M., Au, J. W., Berman, R. F., Jin, L.-W., et al. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-2 · Cited by 90 · see citing works
Rett syndrome: Cerebellar pathology
Oldfors, A., Sourander, P., Armstrong, D. L., Percy, A. K., Witt‐Engerström, I., & Hagberg, B. A. (1990) · Pediatric Neurology · doi:10.1016/0887-8994(90)90022-s · Cited by 89 · see citing works
Pedunculopontine stimulation induces prolonged activation of pontine reticular neurons
García‐Rill, E., Skinner, R. D., Miyazato, H., & Homma, Y. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00094-x · Cited by 84 · see citing works
Martin, L. A., Goldowitz, D., & Mittleman, G. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07073.x · Cited by 82 · see citing works
Self-citationAbnormal brain size effect on the thalamus in autism
Hardan, A. Y., Girgis, R. R., Adams, J., Gilbert, A. R., Keshavan, M. S., & Minshew, N. J. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.12.009 · Cited by 81 · see citing works
Reduced thalamic volume observed across different subgroups of autism spectrum disorders
Tamura, R., Kitamura, H., Endo, T., Hasegawa, N., & Someya, T. (2010) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.07.001 · Cited by 74 · see citing works
Goodrich‐Hunsaker, N. J., Wong, L. M., McLennan, Y. A., Tassone, F., Harvey, D. J., Rivera, S. M., & Simon, T. J. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00063 · Cited by 67 · see citing works
Behavioral flexibility in a mouse model of developmental cerebellar Purkinje cell loss
Dickson, P. E., Rogers, T. D., Mar, N. D., Martin, L. A., Heck, D., Blaha, C. D., Goldowitz, D., & Mittleman, G. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.05.010 · Cited by 59 · see citing works
Self-citationCommons, K. G., & Milner, T. A. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970512)381:3 · Cited by 58 · see citing works
Pathological and neuropathological findings in two males with fragile‐X syndrome
Sabaratnam, M. (2000) · Journal of Intellectual Disability Research · doi:10.1046/j.1365-2788.2000.00261.x · Cited by 56 · see citing works
del Arco, A., & Mora, F. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0172-5 · Cited by 54 · see citing works
Stimulus‐specific plasticity of prefrontal cortex dopamine neurotransmission
Jackson, M., & Moghaddam, B. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02205.x · Cited by 49 · see citing works
Projections from the intracerebellar nuclei to the ventral midbrain tegmentum in the rat
Perciavalle, V., Berretta, S., & Raffaele, R. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90336-9 · Cited by 48 · see citing works
Strazielle, C. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(97)00042-9 · Cited by 47 · see citing works
Rose, J., Schiffer, A., Dittrich, L., & Güntürkün, O. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.004 · Cited by 31 · see citing works
New developments in autism : the future is today
Pérez, J. M. (2007) · Cited by 29 · see citing works
Brain Dopamine and Amino Acid Concentrations in Lurcher Mutant Mice
Reader, T. A., Strazielle, C., Botez, M. I., & Lalonde, R. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00430-9 · Cited by 24 · see citing works
Linnemann, C., Sultan, F. R., Pedroarena, C. M., Schwarz, C., & Thier, P. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00163.2003 · Cited by 22 · see citing works
Long‐term potentiation in the hippocampus of fragile X knockout mice
Godfraind, J., Reyniers, E., Boulle, K. D., D’Hooge, R., Deyn, P. P. D., Bakker, C. E., Oostra, B. A., Kooy, R. F., & Willems, P. J. (1996) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19960809)64:2 · Cited by 16 · see citing works
Changes of dopamine receptors in mice with olivocerebellar degeneration.
Mysliveček, J., Cendelín, J., Korelusová, I., Kunová, M., Markvartová, V., & Vožeh, F. (2007) · PubMed · Cited by 6 · see citing works
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Cerebellar modulation of the reward circuitry and social behavior
Carta, I., Chen, C. H., Schott, A. L., Dorizan, S., & Khodakhah, K. (2019) · Science · doi:10.1126/science.aav0581 · Cited by 601 · see citing works
Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits
Kelly, E., Meng, F., Fujita, H., Morgado, F., Kazemi, Y., Rice, L. C., Ren, C., Escamilla, C. O., Gibson, J. M., Sajadi, S., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0665-z · Cited by 280 · see citing works
Autism spectrum disorder and the cerebellum.
Becker, E. B. E., & Stoodley, C. J. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-418700-9.00001-0 · Cited by 248 · see citing works
Is autism a disease of the cerebellum? An integration of clinical and pre-clinical research
Rogers, T. D., McKimm, E. J., Dickson, P., Goldowitz, D., Blaha, C., & Mittleman, G. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00015 · Cited by 141 · see citing works
Self-citationSensitive Periods for Cerebellar-Mediated Autistic-like Behaviors
Tsai, P. T., Rudolph, S., Guo, C., Ellegood, J., Gibson, J. M., Schaeffer, S. M., Mogavero, J. N., Lerch, J. P., Regehr, W. G., & Şahin, M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.039 · Cited by 109 · see citing works
The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders
Mosconi, M. W., Wang, Z., Schmitt, L. M., Tsai, P., & Sweeney, J. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00296 · Cited by 112 · see citing works
Caligiore, D., Arbib, M. A., Miall, R. C., & Baldassarre, G. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.02.008 · Cited by 105 · see citing works
The Cerebellar Involvement in Autism Spectrum Disorders: From the Social Brain to Mouse Models
Mapelli, L., Soda, T., D'Angelo, E. U., & Prestori, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073894 · Cited by 103 · see citing works
Vasa, R. A., Mostofsky, S. H., & Ewen, J. B. (2016) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.02.003 · Cited by 97 · see citing works
A Working Hypothesis for the Role of the Cerebellum in Impulsivity and Compulsivity
Miquel, M., Nicola, S. M., Gil‐Miravet, I., Guarque‐Chabrera, J., & Sanchez-Hernandez, A. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00099 · Cited by 89 · see citing works
Gholizadeh, S., Arsenault, J., Xuan, I., Pacey, L. K., & Hampson, D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.167 · Cited by 83 · see citing works
Prenatal risk factors for Tourette Syndrome: a systematic review
Chao, T., Hu, J. Y., & Pringsheim, T. M. (2014) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-14-53 · Cited by 86 · see citing works
The Neuronal Code(s) of the Cerebellum
Heck, D. H., Zeeuw, C. I. D., Jaeger, D., Khodakhah, K., & Person, A. L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2759-13.2013 · Cited by 79 · see citing works
Self-citationThe therapeutic potential of the cerebellum in schizophrenia
Parker, K. L., Narayanan, N. S., & Andreasen, N. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00163 · Cited by 78 · see citing works
Dysfunctional dopaminergic neurotransmission in asocial BTBR mice
Squillace, M., Dodero, L., Federici, M., Migliarini, S., Errico, F., Napolitano, F., Krashia, P., Maio, A. D., Galbusera, A., Bifone, A., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.69 · Cited by 73 · see citing works
The Cerebellar Dopaminergic System
Flace, P., Livrea, P., Basile, G. A., Galletta, D., Bizzoca, A., Gennarini, G., Bertino, S., Branca, J. J. V., Gulisano, M., Bianconi, S., et al. (2021) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2021.650614 · Cited by 72 · see citing works
Meta-analytic connectivity and behavioral parcellation of the human cerebellum
Riedel, M. C., Ray, K. L., Dick, A. S., Sutherland, M. T., Hernandez, Z., Fox, P. M., Eickhoff, S. B., Fox, P. T., & Laird, A. R. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.05.008 · Cited by 69 · see citing works
Kramvis, I., Mansvelder, H. D., Loos, M., & Meredith, R. M. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00172 · Cited by 52 · see citing works
Recent Advances in the Understanding of Specific Efferent Pathways Emerging From the Cerebellum
Kang, S., Jun, S., Baek, S. J., Park, H., Yamamoto, Y., & Tanaka, K. (2021) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2021.759948 · Cited by 53 · see citing works
Kelly, E., Escamilla, C. O., & Tsai, P. T. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.012 · Cited by 43 · see citing works
New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment
Faris, P. S., Pischedda, D., Palesi, F., & D'Angelo, E. U. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1386583 · Cited by 44 · see citing works
Autism and cerebellar dysfunction: Evidence from animal models
Tsai, P. T. (2016) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2016.04.009 · Cited by 38 · see citing works
Cerebellum and cognition: Does the rodent cerebellum participate in cognitive functions?
Shipman, M. L., & Green, J. T. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.02.006 · Cited by 41 · see citing works
Linke, A. C., Kinnear, M., Kohli, J. S., Fong, C., Lincoln, A. J., Carper, R. A., & Müller, R. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.09.018 · Cited by 40 · see citing works
Modeling dopamine dysfunction in autism spectrum disorder: from invertebrates to vertebrates
DiCarlo, G. E., & Wallace, M. T. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.12.017 · Cited by 39 · see citing works
Trobiani, L., Favaloro, F. L., Castro, M. A. D., Mattia, M. D., Cariello, M., Miranda, E., Canterini, S., Stefano, M. E. D., Comoletti, D., Limatola, C., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.08.026 · Cited by 34 · see citing works
A unified circuit for social behavior
Modi, M. E., & Şahin, M. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.08.010 · Cited by 34 · see citing works
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Holloway, Z. R., Paige, N. B., Comstock, J. F., Nolen, H. G., Sable, H. J. K., & Lester, D. B. (2019) · The Cerebellum · doi:10.1007/s12311-019-01074-w · Cited by 35 · see citing works
Tůma, J., Kolinko, Y., Vožeh, F., & Cendelín, J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00116 · Cited by 33 · see citing works
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Froula, J. M., Hastings, S. D., & Krook-Magnuson, E. I. (2023) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2023.1158492 · Cited by 34 · see citing works
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Dickson, P. E., Cairns, J., Goldowitz, D., & Mittleman, G. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.040 · Cited by 32 · see citing works
Self-citationDickson, P. E., Corkill, B., McKimm, E., Miller, M. M., Calton, M. A., Goldowitz, D., Blaha, C. D., & Mittleman, G. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.060 · Cited by 30 · see citing works
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Wang, P., Cai, J., Ni, J., Zhang, J., Tang, W., & Zhang, C. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s118160 · Cited by 30 · see citing works
Franich, K., Wong, H. Y., Yu, A. C. L., & To, C. K. S. (2020) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-020-04758-z · Cited by 30 · see citing works
Anderson, G., & Maes, M. H. J. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120223757 · Cited by 30 · see citing works
D'Angelo, E. U., Soda, T., Mapelli, L., Locatelli, F., Botta, L., Goldfarb, M. P., & Prestori, F. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1985-18.2019 · Cited by 31 · see citing works
Ding, B., Cave, J. W., Dobner, P. R., Mullikin-Kilpatrick, D., Bartzokis, M., Zhu, H., Chow, C.-W., Gronostajski, R. M., & Kilpatrick, D. L. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-07-0476 · Cited by 27 · see citing works
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Wang, H., Pati, S. B. B., Pozzo‐Miller, L. D., & Doering, L. C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00055 · Cited by 25 · see citing works
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Maloney, S. E., Rieger, M. A., & Dougherty, J. D. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-418700-9.00003-4 · Cited by 24 · see citing works
Parker, K. L. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00190 · Cited by 24 · see citing works
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Apps, R., & Watson, T. C. (2012) · Springer eBooks · doi:10.1007/978-94-007-1333-8_48 · Cited by 21 · see citing works
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Prestori, F., Montagna, I., D'Angelo, E. U., & Mapelli, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072494 · Cited by 20 · see citing works
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Ning, Z., McLellan, A. S., Ball, M., Wynne, F., O’Neill, C., Mills, W. E., Quinn, J. P., Kleinjan, D. A., Anney, R., Carmody, R. J., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv231 · Cited by 21 · see citing works
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Rossi, D. J., & Richardson, B. D. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_109 · Cited by 18 · see citing works
McKimm, E., Corkill, B., Goldowitz, D., Albritton, L. M., Homayouni, R., Blaha, C. D., & Mittleman, G. (2013) · The Cerebellum · doi:10.1007/s12311-013-0541-4 · Cited by 16 · see citing works
Self-citationTůma, J., Kolinko, Y., Jelı́nková, D., Hilber, P., & Cendelín, J. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.02.009 · Cited by 15 · see citing works
Richardson, B. D., & Rossi, D. J. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00963.2016 · Cited by 15 · see citing works
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D’Mello, S. R. (2025) · Neurology International · doi:10.3390/neurolint17100173 · Cited by 14 · see citing works
Chen, X. '., Chen, T., Dong, C., Chen, H., Dong, X., Yang, L., Hu, L., Wang, H., Wu, B., Yao, Y., et al. (2022) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2022.02.011 · Cited by 13 · see citing works
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Hanzel, M., Fernando, K., Maloney, S. E., Horn, Z., Gong, S., Mätlik, K., Zhao, J., Pasolli, H. A., Heissel, S., Dougherty, J. D., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2405901121 · Cited by 12 · see citing works
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Niculae, A.-Ş., & Pavăl, D. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.10.016 · Cited by 12 · see citing works
Fatemi, S. H. (2013) · The Cerebellum · doi:10.1007/s12311-013-0484-9 · Cited by 12 · see citing works
Buck, J. M., Yu, L., Knopik, V. S., & Stitzel, J. A. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab138 · Cited by 11 · see citing works
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Peter, S., Zeeuw, C. I. D., Boeckers, T. M., & Schmeißer, M. J. (2017) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-319-52498-6_6 · Cited by 11 · see citing works
Maldonado-García, J. L., Pérez‐Sánchez, G., Becerril‐Villanueva, E., Álvarez-Herrera, S., Pavón, L., Gutiérrez‐Ospina, G., López‐Santiago, R., Maldonado-Tapia, J. O., Pérez‐Tapia, S. M., & Moreno-Lafont, M. C. (2021) · Microorganisms · doi:10.3390/microorganisms9091937 · Cited by 9 · see citing works
Abirami, G. P. P., Radhakrishnan, R. K., Johnson, E., Roshan, S. A., Yesudhas, A., Parveen, S., Biswas, A., Ravichandran, V. R., Anusuyadevi, M., & Kandasamy, M. (2020) · Advances in neurobiology · doi:10.1007/978-3-030-30402-7_8 · Cited by 9 · see citing works
Jackson, T. W., Bendfeldt, G. A., Beam, K. A., Rock, K. D., & Belcher, S. M. (2020) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2020.106866 · Cited by 9 · see citing works
Wu, S., Wen, Z., Yang, W., Jiang, C., Zhou, Y., Zhao, Z., Zhou, A., Liu, X., Wang, X., Wang, Y., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1097244 · Cited by 9 · see citing works
Zhou, P., Peng, S., Wen, S., Lan, Q., Zhuang, Y., Li, X., Shi, M., & Zhang, C. (2024) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s485487 · Cited by 7 · see citing works
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Chiou, L., & Sieghart, W. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107613 · Cited by 7 · see citing works
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Heck, D. H., & Howell, J. W. (2013) · Autism - Open Access · doi:10.4172/2165-7890.s4-001 · Cited by 6 · see citing works
Self-citationMohammadpanah, M., Farrokhi, S., Sani, M., Moghaddam, M. H., Bayat, A., Boroujeni, M. E., Abdollahifar, M., Fathi, M., Vakili, K. G., Nikpour, F., et al. (2023) · Toxicology Research · doi:10.1093/toxres/tfad098 · Cited by 6 · see citing works
Mittleman, G., & Blaha, C. D. (2015) · Contemporary clinical neuroscience · doi:10.1007/978-1-4939-2190-4_11 · Cited by 5 · see citing works
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Caligiore, D., & Mirino, P. (2020) · International Journal of Neural Systems · doi:10.1142/s0129065720500410 · Cited by 5 · see citing works
Silkis, I. G. (2022) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-022-01330-3 · Cited by 4 · see citing works
Silkis, I. G. (2021) · Integrative Physiology · doi:10.33910/2687-1270-2021-2-2-135-146 · Cited by 4 · see citing works
An Immunohistochemical Analysis on The Human Cerebellar Dopaminergic SystemPreprint
Flace, P., Livrea, P., Galletta, D., Bizzoca, A., Basile, G. A., Branca, J. J. V., Gulisano, M., Cacciola, A., Gennarini, G., Milardi, D., et al. (2020) · doi:10.21203/rs.3.rs-30289/v1 · Cited by 4 · see citing works
Cerebro-Cerebellar Connections
Watson, T. C., & Apps, R. (2019) · Springer eBooks · doi:10.1007/978-3-319-97911-3_48-3 · Cited by 3 · see citing works
Cerebro-cerebellar Connections
Watson, T. C., & Apps, R. (2021) · Springer eBooks · doi:10.1007/978-3-030-23810-0_48 · Cited by 2 · see citing works
Lurcher Mouse as a Model of Cerebellar Syndromes
Choudhury, N. R., Hilber, P., & Cendelín, J. (2025) · The Cerebellum · doi:10.1007/s12311-025-01810-5 · Cited by 1 · see citing works
Bidirectional interactions between neuromodulatory systems and the cerebellum in brain function
Kim, T., Park, H., Jun, S., Park, J., Yamamoto, Y., & Tanaka, K. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106716 · Cited by 1 · see citing works
Cunha, C. D., McKimm, E., Cunha, R. M. D., Boschen, S. L., Redgrave, P., & Blaha, C. D. (2017) · Brain Research · doi:10.1016/j.brainres.2017.05.002 · Cited by 1 · see citing works
Self-citationThe Role of the Cerebellum in Cognitive and Affective Processes
Walsh, K. P., & Parker, K. L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.99805-2 · Cited by 1 · see citing works
Wang, C., Wang, S.-Y., Ma, K.-Y., Wang, Z.-X., Xu, F., Wu, Z., Gu, Y., Chen, W., Shen, Y., Su, L., et al. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01285-0 · Cited by 1 · see citing works
L1-79 and the Role of Catecholamines in Autism
Rothman, J. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.95052 · Cited by 1 · see citing works
Cognition, Motor Control and Other Aspects of Autism: A Pragmatic Review
Howell, J. W., & Heck, D. H. (2015) · Contemporary clinical neuroscience · doi:10.1007/978-1-4939-2190-4_19 · Cited by 1 · see citing works
Self-citationVirus-mediated Delivery of the Fmr1 Gene as a Tool for the Treatment of Fragile X Syndrome
Moghaddam, S. G. (2016) · TSpace (University of Toronto)
The Role Of The Prelimbic, Infralimbic, And Cerebellar Cortices In Operant Behavior
Shipman, M. L. (2019) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
Cerebro-Cerebellar Connections
Watson, T. C., & Apps, R. (2019) · Springer eBooks · doi:10.1007/978-3-319-97911-3_48-2
Olive, M. F. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734873110.793555753
Wise, R. A. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734873110.793560131
Vanderschuren, L. J. M. J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734873110.793560144
Cendelín, J., Tuma, J., & Purkartová, Z. (2023) · Springer eBooks · doi:10.1007/978-3-031-15070-8_63
Pour, M. G., & Alaei, H. (2023) · Research in Pharmaceutical Sciences · doi:10.4103/1735-5362.389957
Lyle, T. T., Elbeh, K. M., Chambers, D., Vieira, H., & Verpeut, J. L. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03404-3
Bermudez-Martin, P. (2020) · theses.fr (ABES) · doi:10.70675/d0d223ffzbc0ez44d9z8475z153f265e94f5
ASTN2 in ASD and neurodevelopmental disorders
Govek, E., Hull, C., & Hatten, M. E. (2026) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2026.02.003
- Authors
- Rogers, T. D., Dickson, P. E., McKimm, E., Heck, D. H., Goldowitz, D., Blaha, C. D., & Mittleman, G.
- Affiliations
- University of Memphis (US)
- University of Tennessee Health Science Center (US)
- University of British Columbia (CA)
- Corresponding author
- Blaha, Charles D.
- Venue
- The Cerebellum
- Published
- 2013-02-26
- Volume
- 12
- Issue
- 4
- Pages
- 547-556
- ISSN
- 1473-4222 (ISSN-L)
- 1473-4230
- PMC
- PMC3854915
- OpenAlex
- W2091901281
- Cited by
- 89
- References
- 66
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 9 · 2019: 13 · 2018: 6 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 5 · 2013: 9 · 2012: 1
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- The Cerebellum (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS063009)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- cerebellum, medial prefrontal cortex, dopamine release, autism spectrum disorder, ventral tegmental area, thalamus, mediodorsal thalamus, ventrolateral thalamic nucleus, Purkinje cell degeneration, fragile X syndrome, Fmr1 knockout mice, circuit reorganization, lidocaine, kynurenic acid
- MeSH terms
- Animals, Cerebellum, Child Development Disorders, Pervasive, Disease Models, Animal, Dopamine, Kynurenic Acid, Lidocaine, Male, Mice, Inbred CBA, Mice, Neurologic Mutants, Nerve Net, Neuronal Plasticity, Prefrontal Cortex, Mice, Knockout, Mice, Mice, 129 Strain, Infusions, Intraventricular
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