The DOI matches its Crossref record; 54 of the 56 references it cites were found in a registry or an index.
Meta-analysis of gene–environment interactions in developmental psychopathology
Abstract
As studies of measured gene–environment interactions (G × E) in developmental psychopathology gain momentum, methods for systematically and quantitatively summarizing effects across multiple studies are urgently needed. Meta-analyses of G × E findings are critical for evaluating the overall statistical and theoretical significance of any given G × E based on cumulative and systematically combined knowledge. Although meta-analytic methods for the combination of study findings based on single effect measures such as odds ratios and mean differences are well established, equivalent methods for the meta-analysis of studies investigating interactions are not well developed. This article describes one simple approach to the meta-analysis of G × E effects using, as a contemporaneous example, the interaction of the monoamine oxidase A ( MAOA ) gene and the impact of childhood maltreatment on risk for developing antisocial behavior.
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“children carrying specific genetic variants are at increased risk for behavioral problems in later life, but only when raised in dysfunctional families [33]”
From Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care? (2020) · cites this paper as [33]
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Metadata
- Authors
- Taylor, A., & Kim-Cohen, J.
- Affiliations
- King's College London (GB)
- Yale University
- Corresponding author
- Taylor, Alan
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007
- Volume
- 19
- Issue
- 4
- Pages
- 1029-1037
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- OpenAlex
- W2133897913
- Cited by
- 227
- References
- 56
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 1 · 2020: 29 · 2019: 6 · 2018: 8 · 2017: 11 · 2016: 10 · 2015: 15 · 2014: 21 · 2013: 24 · 2012: 17
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- gene-environment interaction, developmental psychopathology, monoamine oxidase A, MAOA gene, child abuse, antisocial behavior
- MeSH terms
- Adolescent, Adult, Antisocial Personality Disorder, Mental Disorders, Child, Child Abuse, Developmental Disabilities, Child, Preschool, Crime, Genotype, Humans, Infant, Longitudinal Studies, Monoamine Oxidase, Social Environment, Meta-Analysis as Topic, Odds Ratio, Conduct Disorder, Genetic Predisposition to Disease
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