Cited by 227Meta-analysis and systematic reviewsChild and Adolescent Psychosocial and Emotional DevelopmentPsychopathy, Forensic Psychiatry, Sexual Offending

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Meta-analysis of gene–environment interactions in developmental psychopathology

Taylor, Alan, Kim-Cohen, Julia·2007·Development and Psychopathology

DOI 10.1017/s095457940700051x

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Abstract

As studies of measured gene–environment interactions (G × E) in developmental psychopathology gain momentum, methods for systematically and quantitatively summarizing effects across multiple studies are urgently needed. Meta-analyses of G × E findings are critical for evaluating the overall statistical and theoretical significance of any given G × E based on cumulative and systematically combined knowledge. Although meta-analytic methods for the combination of study findings based on single effect measures such as odds ratios and mean differences are well established, equivalent methods for the meta-analysis of studies investigating interactions are not well developed. This article describes one simple approach to the meta-analysis of G × E effects using, as a contemporaneous example, the interaction of the monoamine oxidase A ( MAOA ) gene and the impact of childhood maltreatment on risk for developing antisocial behavior.

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“With these two studies added to the aforementioned meta-analysis, the correlation between maltreatment and conduct problems was .13 in high-activity genotype individuals, and .30 in low-activity genotype individuals (Taylor & Kim-Cohen, 2007).”
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Authors: Taylor, A., & Kim-Cohen, J.
Affiliations: King's College London (GB)
Yale University
Corresponding author: Taylor, Alan
Venue: Development and Psychopathology
Publisher: Cambridge University Press (CUP)
Published: 2007
Volume: 19
Issue: 4
Pages: 1029-1037
ISSN: 0954-5794 (ISSN-L)
1469-2198
DOI: 10.1017/s095457940700051x
OpenAlex: W2133897913
Cited by: 227
References: 56
Citations by year: 2025: 2 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 1 · 2020: 29 · 2019: 6 · 2018: 8 · 2017: 11 · 2016: 10 · 2015: 15 · 2014: 21 · 2013: 24 · 2012: 17
FWCI: 3.64
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 283 d)
Locations: Development and Psychopathology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords: gene-environment interaction, developmental psychopathology, monoamine oxidase A, MAOA gene, child abuse, antisocial behavior
MeSH terms: Adolescent, Adult, Antisocial Personality Disorder, Mental Disorders, Child, Child Abuse, Developmental Disabilities, Child, Preschool, Crime, Genotype, Humans, Infant, Longitudinal Studies, Monoamine Oxidase, Social Environment, Meta-Analysis as Topic, Odds Ratio, Conduct Disorder, Genetic Predisposition to Disease

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Meta-analysis of gene–environment interactions in developmental psychopathology

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