Cited by 227Meta-analysis and systematic reviewsChild and Adolescent Psychosocial and Emotional DevelopmentPsychopathy, Forensic Psychiatry, Sexual Offending

The DOI matches its Crossref record; 54 of the 56 references it cites were found in a registry or an index.

Meta-analysis of gene–environment interactions in developmental psychopathology

Taylor, Alan, Kim-Cohen, Julia·2007·Development and Psychopathology

DOI 10.1017/s095457940700051x

Open this paper in CoChat — free account

Abstract

As studies of measured gene–environment interactions (G × E) in developmental psychopathology gain momentum, methods for systematically and quantitatively summarizing effects across multiple studies are urgently needed. Meta-analyses of G × E findings are critical for evaluating the overall statistical and theoretical significance of any given G × E based on cumulative and systematically combined knowledge. Although meta-analytic methods for the combination of study findings based on single effect measures such as odds ratios and mean differences are well established, equivalent methods for the meta-analysis of studies investigating interactions are not well developed. This article describes one simple approach to the meta-analysis of G × E effects using, as a contemporaneous example, the interaction of the monoamine oxidase A ( MAOA ) gene and the impact of childhood maltreatment on risk for developing antisocial behavior.

Integrity signals

Registry

Crossref · 10.1017/s095457940700051x

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
Multiple regression: testing and interpreting interactions
(1992) · Choice Reviews Online · doi:10.5860/choice.29-3352 · Cited by 36,647
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
Untitled work
(2000) · Cited by 9,198
Cochrane Handbook for Systematic Reviews of Interventions
Higgins, J. P. T., Green, S., & Ben Van Den, A. (2020) · International Coaching Psychology Review · doi:10.53841/bpsicpr.2020.15.2.123 · Cited by 5,670
Methods of Meta-Analysis: Correcting Error and Bias in Research Findings
Schmidt, F. L., & Hunter, J. E. (2015) · doi:10.4135/9781483398105 · Cited by 5,542

Show all 56 references

Research works printed but not linked: 2

Little, 2006, The HuGENet™ HuGE review handbook
The Cochran Collaboration. (2002). Review manager (RevMan). Version 4.2 for Windows [Software]. Oxford: Author.

Sorted by citations

Resilience under conditions of extreme stress: a multilevel perspective
Cicchetti, D. (2010) · World Psychiatry · doi:10.1002/j.2051-5545.2010.tb00297.x · Cited by 802
Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care?
Colizzi, M., Lasalvia, A., & Ruggeri, M. (2020) · International Journal of Mental Health Systems · doi:10.1186/s13033-020-00356-9 · Cited by 727
Neuroimaging of child abuse: a critical review
Hart, H., & Rubia, K. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00052 · Cited by 660
Research Review: The neurobiology and genetics of maltreatment and adversity
McCrory, E., De Brito, S. A., & Viding, E. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02271.x · Cited by 598
Research Review: DSM‐V conduct disorder: research needs for an evidence base
Moffitt, T. E., order, A. I. A., Arseneault, L., Jaffee, S. R., Kim‐Cohen, J., Koenen, K. C., Odgers, C. L., Slutske, W. S., & Viding, E. M. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01823.x · Cited by 457
“With these two studies added to the aforementioned meta-analysis, the correlation between maltreatment and conduct problems was .13 in high-activity genotype individuals, and .30 in low-activity genotype individuals (Taylor & Kim-Cohen, 2007).”
MethodSelf-citation
MAOA, Childhood Maltreatment, and Antisocial Behavior: Meta-analysis of a Gene-Environment Interaction
Byrd, A. L., & Manuck, S. B. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.004 · Cited by 411
The prevalence of personality disorders in the community: a global systematic review and meta-analysis
Winsper, C., Bilgin, A., Thompson, A. D., Marwaha, S., Chanen, A. M., Singh, S. P., Wang, A., & Furtado, V. A. (2019) · The British Journal of Psychiatry · doi:10.1192/bjp.2019.166 · Cited by 406
“31 We also examined the impact of self-report questionnaires on prevalence figures, as they have been associated with the over-diagnosis of personality disorders.”
Etiology in psychiatry: embracing the reality of poly‐gene‐environmental causation of mental illness
Uher, R., & Zwicker, A. (2017) · World Psychiatry · doi:10.1002/wps.20436 · Cited by 331
The Impact of Childhood Maltreatment: A Review of Neurobiological and Genetic Factors
McCrory, E., De Brito, S. A., & Viding, E. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00048 · Cited by 329
Genetics of Human Social Behavior
Ebstein, R. P., Israel, S., Chew, S. H., Zhong, S., & Knafo, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.020 · Cited by 323
Gene-Environment Interaction
Manuck, S. B., & McCaffery, J. M. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115100 · Cited by 296
Gene-environment interaction and psychiatric disorders: Review and future directions
Assary, E., Vincent, J. P., Keers, R., & Pluess, M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.10.016 · Cited by 295
The Genetic Basis of Addictive Disorders
Ducci, F., & Goldman, D. (2012) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2012.03.010 · Cited by 303
Genetic approaches to addiction: genes and alcohol
Ducci, F., & Goldman, D. A. (2008) · Addiction · doi:10.1111/j.1360-0443.2008.02203.x · Cited by 253
“Several studies have tried to replicate this finding, and a recent meta-analysis revealed a significant pooled effect [78].”
Result
Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression
Vassos, E., Collier, D. A., & Fazel, S. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.31 · Cited by 234
Genetics of human aggressive behaviour
Craig, I. W., & Halton, K. E. (2009) · Human Genetics · doi:10.1007/s00439-009-0695-9 · Cited by 213
Trauma in early childhood: Empirical evidence and clinical implications
Lieberman, A. F., Chu, A. T., Horn, P. V., & Harris, W. W. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000137 · Cited by 228
“Two recent meta-analyses reported small to medium effect sizes (0.17 and 0.18) for the monoamine oxidase A genotype and maltreatment interaction for antisocial behavior (KimCohen et al., 2006; Taylor & Kim-Cohen, 2007).”
BackgroundInfluential
Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: Depressive symptomatology among adolescents from low socioeconomic status backgrounds
Cicchetti, D., Rogosch, F. A., & Sturge-Apple, M. L. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000600 · Cited by 204
Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: A systematic review and meta-analysis
Wang, Q., Shelton, R. C., & Dwivedi, Y. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.08.066 · Cited by 201
“Our meta-analysis based on Fisher Z score transformation of correlations method provided a reliable approach to investigate gene x environment effect (Taylor and Kim-Cohen, 2007).”
Method
Do core interpersonal and affective traits of PCL-R psychopathy interact with antisocial behavior and disinhibition to predict violence?
Kennealy, P. J., Skeem, J. L., Walters, G. D., & Camp, J. (2010) · Psychological Assessment · doi:10.1037/a0019618 · Cited by 212
MAOA Genotype, Maltreatment, and Aggressive Behavior: The Changing Impact of Genotype at Varying Levels of Trauma
Weder, N., Yang, B. Z., Douglas-Palumberi, H., Massey, J., Krystal, J. H., Gelernter, J., & Kaufman, J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.013 · Cited by 190
“17 for the G×E interaction involving the MAOA gene (18).”
Background
A critical review of methods for the assessment of patient-level interactions in individual participant data meta-analysis of randomized trials, and guidance for practitioners
Fisher, D. J., Copas, A. J., Tierney, J. F., & Parmar, M. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.11.016 · Cited by 180
Longterm Consequences of Child Maltreatment
Widom, C. S. (2013) · Child maltreatment · doi:10.1007/978-94-007-7208-3_12 · Cited by 171
Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress
Boyce, W. T. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.294 · Cited by 164
The implications of gene–environment interactions in depression: will cause inform cure?
Uher, R. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.92 · Cited by 147
Omega 3 polyunsaturated fatty acids and the treatment of depression
Deacon, G., Kettle, C., Hayes, D., Dennis, C., & Tucci, J. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.876959 · Cited by 149
MAOA, abuse exposure and antisocial behaviour: 30-year longitudinal study
Fergusson, D. M., Boden, J. M., Horwood, L. J., Miller, A. L., & Kennedy, M. A. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.110.086991 · Cited by 147
Underlying Mechanisms of Gene–Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms
Weeland, J., Overbeek, G., de Castro, B. O., & Matthys, W. (2015) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-015-0196-4 · Cited by 138
“Multiple meta-analyses on cG 9 E in externalizing behaviors have already been published, but these have mostly focused on the MAOA gene (Byrd and Manuck 2014; Kim-Cohen et al. 2006; Taylor and Kim-Cohen 2007).”
Method
The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men
Kolla, N. J., & Bortolato, M. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101875 · Cited by 138
“Nevertheless, three independent meta-analyses to this date (Kim-Cohen et al., 2006; Taylor and Kim-Cohen, 2007; Byrd and Manuck, 2014) have validated the existence of this G × E interaction and detected an effect size of approximately 0.”
Background
Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior
Wakschlag, L. S., Kistner, E. O., Pine, D. S., Biesecker, G., Pickett, K. E., Skol, A. D., Dukić, V., Blair, J., LEVENTHAL, B. L., Cox, N. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.22 · Cited by 133
Generalized Anxiety Disorder: Connections With Self-Reported Attachment
Cassidy, J. A., PHELPS, J. L., Sibrava, N. J., Thomas, C. L., & Borkovec, T. D. (2008) · Behavior Therapy · doi:10.1016/j.beth.2007.12.004 · Cited by 148
“…transactional perspective (Sameroff & Chandler, 1975; see also recent theory and research related to Gene × Environment interaction, Cicchetti, 2007; Taylor & Kim-Cohen, 2007), attachment theorists have proposed a model that places childhood attachment “ in the context of a large array of…”
Childhood trauma in mood disorders: Neurobiological mechanisms and implications for treatment
Jaworska-Andryszewska, P., & RYBAKOWSKI, J. K. (2018) · Pharmacological Reports · doi:10.1016/j.pharep.2018.10.004 · Cited by 133
The Concept of Development in Developmental Psychopathology
Sroufe, L. A. (2009) · Child Development Perspectives · doi:10.1111/j.1750-8606.2009.00103.x · Cited by 147
“Finally, numerous replications of the Caspi study find a main effect for maltreatment (see Taylor & Kim-Cohen, 2007, for a review), and, further, maltreatment has a range of associated outcomes other than conduct problems, so it is doubly shortsighted to imply that maltreatment has an effect only…”
Background
Clinical Implications of Traumatic Stress from Birth to Age Five
Chu, A. T., & Lieberman, A. F. (2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.121208.131204 · Cited by 127
Expanding our lens: Female pathways to antisocial behavior in adolescence and adulthood
Javdani, S., Sadeh, N., & Verona, E. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2011.09.002 · Cited by 108
“…the MAO-A short allele predict antisocial behavior in boys (Caspi et al., 2002; Foley et al., 2004; Kim-Cohen et al., 2006; Nilsson et al., 2007; Taylor & Kim-Cohen, 2007; Widom & Brzustowicz, 2006), though some investigations have not replicated this finding (e.g., Prichard, Mackinnon, Jorm, &…”
Result
Measured Gene–Environment Interactions and Mechanisms Promoting Resilient Development
Kim‐Cohen, J., & Gold, A. L. (2009) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2009.01624.x · Cited by 105
“…can be definitively confirmed, both findings have been replicated in several independent studies and a meta-analysis (Kim-Cohen et al., 2006; Taylor & Kim-Cohen, 2007; Uher & McGuffin, 2007), indicating that, rather than having a direct and linear association to mental health outcomes,…”
BackgroundResultSelf-citation
Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity
Fowler, T., Langley, K., Rice, F. J., van den Bree, M. B. M., Ross, K., Wilkinson, L. S., Owen, M. J., O’Donovan, M. C., & Thapar, A. (2009) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3283328df4 · Cited by 100
“…environmental adversity as there have now been many published studies showing that the MAOA variant low-activity alleles increase the risk of antisocial behaviour only in the presence of early adversity (Caspi et al., 2002; Kim-Cohen et al., 2006; Taylor and Kim-Cohen, 2007; Thapar et al., 2007).”
BackgroundMethod
Vantage sensitivity: environmental sensitivity to positive experiences as a function of genetic differences
Pluess, M. (2017) · Journal of Personality · doi:10.1111/jopy.12218 · Cited by 90
MAOA Genotype, Childhood Maltreatment, and Their Interaction in the Etiology of Adult Antisocial Behaviors
Haberstick, B. C., Lessem, J. M., Hewitt, J. K., Smolen, A., Hopfer, C. J., Halpern, C. T., Killeya‐Jones, L. A., Boardman, J. D., Tabor, J. W., Siegler, I. C., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.028 · Cited by 99
“Effect sizes from existing metaanalyses and other single-sample studies (28,32,39,40) are similar, demonstrating small to moderate effects ranging between .”
Genes, Environment, and Individual Differences in Responding to Treatment for Depression
Uher, R. (2011) · Harvard Review of Psychiatry · doi:10.3109/10673229.2011.586551 · Cited by 93
Therapygenetics: Using genetic markers to predict response to psychological treatment for mood and anxiety disorders
Lester, K. J., & Eley, T. C. (2013) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-3-4 · Cited by 95
“However, the association between childhood maltreatment and antisocial behaviour is weak in those carrying the high expression long alleles [22].”
Background
The developmental origins of chronic physical aggression: biological pathways triggered by early life adversity
Provençal, N., Booij, L., & Tremblay, R. E. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.111401 · Cited by 101
“…studies were able to confirm a significant MAOA×child abuse interaction that predicts antisocial behaviour in men, whereas these results turned out to be less consistent in women and this requires further investigation (Byrd and Manuck, 2014; Kim-Cohen et al., 2006; Taylor and Kim-Cohen, 2007).”
Result
A Polymorphism of the MAOA Gene is Associated with Emotional Brain Markers and Personality Traits on an Antisocial Index
Williams, L. M., Gatt, J. M., Kuan, S. A., Dobson‐Stone, C., Palmer, D. M., Paul, R. H., Song, L., Costa, P. T., Schofield, P. R., & Gordon, E. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.1 · Cited by 87
“Exposure to early life stress did not interact with MAOA-L for its impact on both the FFI-AI and ERPs, but such interactions may be apparent in clinical samples, as observed previously (Kim-Cohen et al, 2006; Taylor and Kim-Cohen, 2007).”
Violence Among People with Schizophrenia: Phenotypes and Neurobiology
Hodgins, S., Piatosa, M. J., & Schiffer, B. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2013_259 · Cited by 93
Multiple developmental pathways to conduct disorder: current conceptualizations and clinical implications.
Pardini, D. A., & Frick, P. J. (2013) · Europe PMC (PubMed Central) · Cited by 88
Harsh Parenting As a Potential Mediator of the Association Between Intimate Partner Violence and Child Disruptive Behavior in Families With Young Children
Grasso, D. J., Henry, D. B., Kestler, J., Nieto, R., Wakschlag, L. S., & Briggs‐Gowan, M. J. (2015) · Journal of Interpersonal Violence · doi:10.1177/0886260515572472 · Cited by 87
“…(Crick & Dodge, 1996), as well as gene–environment interactions or epigenetic changes that interfere with the development of stress regulation (Radtke et al., 2011; Taylor & Kim-Cohen, 2007)—all likely contributory processes in the intergenerational transmission of behavioral dysregulation.”
Background
Gene–environment interactions in common mental disorders: an update and strategy for a genome-wide search
Uher, R. (2013) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-013-0801-0 · Cited by 88
“antisocial behavior is particularly impressive: it includes 20 studies showing consistent findings across populations [16, 24, 25].”
Background
Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood
Nemoda, Z., Szekely, A., & Sasvari-Szekely, M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.002 · Cited by 78
Neuroprediction, Violence, and the Law: Setting the Stage
Nadelhoffer, T., Bibas, S., Grafton, S. T., Kiehl, K. A., Mansfield, A., Sinnott-Armstrong, W. P., & Gazzaniga, M. S. (2010) · Neuroethics · doi:10.1007/s12152-010-9095-z · Cited by 84
Resiliencia: una aproximación al concepto
Truffino, J. C. (2010) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2010.09.003 · Cited by 116
Child Abuse and Neglect, MAOA, and Mental Health Outcomes: A Prospective Examination
Nikulina, V., Widom, C. S., & Brzustowicz, L. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.008 · Cited by 79
“A recent meta-analysis showed a significant effect of the interaction of MAOA genotype and child maltreatment on antisocial behaviors [46].”
Childhood maltreatment and prospectively observed quality of early care as predictors of antisocial personality disorder features
Shi, Z., Bureau, J., Easterbrooks, M. A., Zhao, X., & Lyons‐Ruth, K. (2012) · Infant Mental Health Journal · doi:10.1002/imhj.20295 · Cited by 76
“Molecular genetic studies indicate that there are gene-environment interactions in the development of antisocial behavior involving serotonin-related genes (Caspi et al., 2002; Ducci et al., 2008; Taylor & Kim-Cohen, 2007).”
Background
Molecular genetics and antisocial behavior: Where do we stand?
Iofrida, C., Palumbo, S., & Pellegrini, S. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214529508 · Cited by 81
Krieg im Zuhause – ein Überblick zum Zusammenhang zwischen Kriegstraumatisierung und familiärer Gewalt
Catani, C. (2009) · Verhaltenstherapie · doi:10.1159/000261994 · Cited by 69
The forensic use of behavioral genetics in criminal proceedings: Case of the MAOA-L genotype
McSwiggan, S., Elger, B. S., & Appelbaum, P. S. (2016) · International Journal of Law and Psychiatry · doi:10.1016/j.ijlp.2016.09.005 · Cited by 80
“Despite this, two meta-analyses of MAOA-L genotype have found the gene–environment interaction to be moderately reliable (Byrd & Manuck, 2014; Taylor & Kim-Cohen, 2007).”
Background
5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder
Douglas, K., Chan, G., Gelernter, J. E., Arias, A. J., Anton, R. F., Poling, J. C., Farrer, L. A., & Kranzler, H. R. (2011) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3283457c15 · Cited by 68
“A meta-analysis of this research supports a modest interaction effect, with individuals possessing the high-risk MAOA genotype and having experienced childhood maltreatment showing a greater risk for ASPD than those with either condition alone (Taylor and Kim-Cohen, 2007).”
Method
Basing psychiatric classification on scientific foundation: Problems and prospects
Uher, R., & Rutter, M. L. (2012) · International Review of Psychiatry · doi:10.3109/09540261.2012.721346 · Cited by 69
“, 2002; Taylor & Kim-Cohen, 2007) and the interaction between the length polymorphism of the serotonin transporter gene and childhood maltreatment leads to persistent depression but not anxiety or conduct disorder (Caspi et al .”
Background
Effects of Child Maltreatment and Inherited Liability on Antisocial Development: An Official Records Study
Jonson‐Reid, M., Presnall, N. J., Drake, B., Fox, L. W., Bierut, L. J., Reich, W., Kane, P., Todd, R. D., & Constantino, J. N. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2009.11.015 · Cited by 66
“In contrast to a number of previous research studies employing alternate designs [10], we did not observe statistically significant interactive effects of inherited liability and maltreatment on antisocial development, despite the fact that our observations of the influence of inherited factors were highly in keeping…”
MAOA genotype, social exclusion and aggression: an experimental test of a gene–environment interaction
Gallardo‐Pujol, D., Pueyo, A. A., & Maydeu‐Olivares, A. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00868.x · Cited by 75
Gender and the Development of Aggression, Disruptive Behavior, and Delinquency from Childhood to Early Adulthood
Loeber, R., Capaldi, D. M., & Costello, E. J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7557-6_6 · Cited by 66
Genetic Risk for Violent Behavior and Environmental Exposure to Disadvantage and Violent Crime
Barnes, J. C., & Jacobs, B. A. (2012) · Journal of Interpersonal Violence · doi:10.1177/0886260512448847 · Cited by 70
“A recent meta-analysis supported the GxE between MAOA genotype and childhood maltreatment in the prediction of antisocial behavior (Kim-Cohen et al., 2006; Taylor & Kim-Cohen, 2007).”
Method
Gene–environment interactions reexamined: Does mother's marital stability interact with the dopamine receptor D2 gene in the etiology of childhood attention-deficit/hyperactivity disorder?
Waldman, I. D. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000570 · Cited by 60
“…MAOA (e.g., Foley et al., 2004; Haberstick et al., 2006; Nilsson, 2005; Young et al., 2005; summarized and metaanalyzed by Kim-Cohen et al., 2006; Taylor & Kim-Cohen, 2007), and 5-HTT findings (e.g., Eley et al., 2004; Gillespie, Whitfield, Williams, Heath, & Martin, 2005; Kendler, Kuhn, Vittum,…”
Resilience: An approach to the concept
Truffino, J. C. (2010) · Revista de Psiquiatría y Salud Mental (English Edition) · doi:10.1016/s2173-5050(10)70024-8 · Cited by 72
Reported early family environment covaries with menarcheal age as a function of polymorphic variation in estrogen receptor-α
Manuck, S. B., Craig, A. E., Flory, J. D., Halder, I., & Ferrell, R. E. (2011) · Development and Psychopathology · doi:10.1017/s0954579410000659 · Cited by 60
“…phenotypes as childhood temperament, early cognitive abilities, juvenile and adult antisocial behavior, and depression (Caspi et al., 2002, 2003, 2007; Cicchetti, Rogosch, & Sturge-Apple, 2007; Moffitt, Caspi, & Rutter, 2005; Scheese, Voelker, Rothbart, & Posner, 2007; Taylor & Kim-Cohen, 2007).”
Biological Implications of Gene–Environment Interaction
Rutter, M. L. (2008) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-008-9256-2 · Cited by 63
“Thus the MAOA finding was subjected to a meta-analysis that confirmed the significant G×E, the statistical significance being evident with or without the original Dunedin study (Kim-Cohen et al. 2006; Taylor and Kim-Cohen 2007).”
Method
Intergenerational Transmission of Multiple Problem Behaviors: Prospective Relationships between Mothers and Daughters
Loeber, R., Hipwell, A. E., Battista, D. R., Sembower, M. A., & Stouthamer‐Loeber, M. (2009) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-009-9337-x · Cited by 58
Reduced functional connectivity of fronto-parietal sustained attention networks in severe childhood abuse
Hart, H. C., Lim, L. L., Mehta, M. A., Chatzieffraimidou, A., Curtis, C. J. C., Xu, X., Breen, G. D., Simmons, A., Mirza, K., & Rubia, K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188744 · Cited by 62
Analysis of monoaminergic genes, childhood abuse, and dimensions of psychopathy.
Sadeh, N., Javdani, S., & Verona, E. (2012) · Journal of Abnormal Psychology · doi:10.1037/a0029866 · Cited by 64
The Monoamine Oxidase A (MAOA) Genetic Predisposition to Impulsive Violence: Is It Relevant to Criminal Trials?
Baum, M. L. (2011) · Neuroethics · doi:10.1007/s12152-011-9108-6 · Cited by 63
“Several other groups confirmed and expanded upon this research over the next 5 years [23].”
Background
Gene × Environment effects of serotonin transporter, dopamine receptor D4, and monoamine oxidase A genes with contextual and parenting risk factors on symptoms of oppositional defiant disorder, anxiety, and depression in a community sample of 4-year-old children
Lavigne, J. V., Herzing, L. B. K., Cook, E. H., LeBailly, S. A., Gouze, K. R., Hopkins, J., & Bryant, F. B. (2013) · Development and Psychopathology · doi:10.1017/s0954579412001241 · Cited by 59
“G E interactions have been found for MAOA and adversity (Prom-Wormley et al., 2009), life trauma (Frazzetto et al., 2007), and child maltreatment (Taylor & Kim-Cohen, 2007).”
Background
Physical punishment and childhood aggression: the role of gender and gene–environment interplay
Boutwell, B. B., Franklin, C. A., Barnes, J. C., & Beaver, K. M. (2011) · Aggressive Behavior · doi:10.1002/ab.20409 · Cited by 54
“Studies examining the biosocial underpinnings of behavior are continuing to provide evidence that both heritable influences and environmental risk factors may work closely together to condition the emergence of antisocial phenotypes [Kim-Cohen et al., 2006; Taylor and Kim-Cohen, 2007].”
BackgroundResult
Neurobiology and the development of violence: common assumptions and controversies
Loeber, R., & Pardini, D. A. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0032 · Cited by 52
Impact of behavioral genetic evidence on the adjudication of criminal behavior.
Appelbaum, P. S., & Scurich, N. (2014) · PubMed · Cited by 52
Early adversity alters brain architecture and increases susceptibility to mental health disorders
Nelson, C. A., Sullivan, E., & Valdes, V. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00948-9 · Cited by 55
5-HTTLPR X Stress in Adolescent Depression: Moderation by MAOA and Gender
Priess, H. A., & Hyde, J. S. (2012) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-012-9672-1 · Cited by 56
Neurolaw and Neuroprediction: Potential Promises and Perils
Nadelhoffer, T., & Sinnott-Armstrong, W. P. (2012) · Philosophy Compass · doi:10.1111/j.1747-9991.2012.00494.x · Cited by 50
Gene × Environment Interaction in Developmental Disorders: Where Do We Stand and What’s Next?
Esposito, G., Azhari, A., & Borelli, J. L. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02036 · Cited by 48
“However, methods for the meta-analysis of studies investigating interactions are not well developed (Taylor and Kim-Cohen, 2007).”
Developmental Psychopathology
Cicchetti, D. (2010) · Wiley eBooks · doi:10.1002/9780470880166.hlsd002014 · Cited by 46
Effects of behavioral genetic evidence on perceptions of criminal responsibility and appropriate punishment.
Appelbaum, P. S., Scurich, N., & Raad, R. (2015) · Psychology Public Policy and Law · doi:10.1037/law0000039 · Cited by 48
“…over 5,800 participants—support the association between MAOA and antisocial behavior by maltreated boys (Byrd & Manuck, 2014; Kim-Cohen et al., 2006; Taylor & Kim-Cohen, 2007).1 Further supporting this finding, the same gene– environment interaction was found to be associated with symptoms of…”
Mechanisms of Gene-Environment Interaction Effects in the Development of Conduct Disorder
Dodge, K. A. (2009) · Perspectives on Psychological Science · doi:10.1111/j.1745-6924.2009.01147.x · Cited by 47
“Taylor and Kim-Cohen (2007) meta-analyzed seven studies ofMAOA Maltreatment interactions and found a .30 pooled estimate of maltreatment effect within lowMAOA activity groups, in contrast with a .13 pooled estimate within high MAOA activity groups.”
Result
Prevention and early intervention for mental health problems in 0–25 year olds: Are there evidence-based models of care?
Catania, L. S., Hetrick, S. E., Newman, L. K., & Purcell, R. (2011) · Advances in Mental Health · doi:10.5172/jamh.2011.10.1.6 · Cited by 41
“…demonstrated a link between a measured genotype and environmental condition for a psychiatric outcome, such that individuals who carried a particular form of a gene were at increased risk for developing antisocial behaviour disorders when subjected to maltreatment (see Taylor & Kim-Cohen, 2007).”
Background
Serotonin pathway gene–gene and gene–environment interactions influence behavioral stress response in infant rhesus macaques
Kinnally, E. L., Karere, G. M., Lyons, L. A., Mendoza, S. P., Mason, W. A., & Capitanio, J. P. (2010) · Development and Psychopathology · doi:10.1017/s0954579409990241 · Cited by 41
“…as children showed an increased risk for antisocial behavior (Caspi et al., 2002; Foley et al., 2004; Kim-Cohen et al., 2006; Nilsson et al., 2007; Taylor & Kim-Cohen, 2007; Vanyukov et al., 2007; although see Haberstick et al., 2005) impulsivity (Huang et al., 2004), and aggression (Frazzetto et…”
Parsing dimensions of family violence exposure in early childhood: Shared and specific contributions to emergent psychopathology and impairment
Briggs‐Gowan, M. J., Estabrook, R., Henry, D. B., Grasso, D. J., Burns, J. L., McCarthy, K. J., Pollak, S. D., & Wakschlag, L. S. (2018) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2018.06.006 · Cited by 41
Psychiatric Genetics in Child Custody Proceedings: Ethical, Legal, and Social Issues
Sabatello, M., & Appelbaum, P. S. (2016) · Current Genetic Medicine Reports · doi:10.1007/s40142-016-0093-2 · Cited by 41
Gene–environment interaction in externalizing problems among adolescents: evidence from the Pelotas 1993 Birth Cohort Study
Kieling, C., Hutz, M. H., Genro, J. P., Polanczyk, G. V., Anselmi, L., Camey, S. A., Hallal, P. C., Barros, F. C., Victora, C. G., Menezes, A. M. B., et al. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12022 · Cited by 39
“The one existing meta-analysis (Taylor & Kim-Cohen, 2007) confirmed the existence of G · E as correlation coefficients between antisocial behavior and maltreatment varied according to MAOA genotype status (0.30; 95%IC 0.24–0.36 for the low activity group and 0.13; 95%IC 0.09–0.17 for the high…”
MethodInfluential
Genetic and Neuroimaging Features of Personality Disorders: State of the Art
Ma, G., Fan, H., Shen, C., & Wang, W. (2016) · Neuroscience Bulletin · doi:10.1007/s12264-016-0027-8 · Cited by 47
MAOA expression predicts vulnerability for alcohol use
Cervera‐Juanes, R. P., Wilhem, L., Park, B., Lee, R. S., Locke, J., Helms, C., Gonzales, S., Wand, G. S., Jones, S. R., Grant, K. A., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.93 · Cited by 38
Gene Expression in Aminergic and Peptidergic Cells During Aggression and Defeat: Relevance to Violence, Depression and Drug Abuse
Miczek, K. A., Nikulina, E. M., Takahashi, A., Covington, H. E., Yap, J. J., Boyson, C. O., Shimamoto, A., & de Almeida, R. M. M. (2011) · Behavior Genetics · doi:10.1007/s10519-011-9462-5 · Cited by 40
“Studies in molecular biology have begun to provide tools for studying how experiences in aggressive confrontations alter the activity of corticolimbic cells, via both genomic and nongenomic action (e.g., Caspi et al. 2002; Craig and Halton 2009; Day et al. 2011; Lesch and Merschdorf 2000; Taylor and Kim-Cohen 2007; Te…”
Background
Effects of paternal and peripubertal stress on aggression, anxiety, and metabolic alterations in the lateral septum
Cordero, M. I., Just, N., Poirier, G. L., & Sandi, C. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.11.017 · Cited by 38
“…biological parents have shown a significant increase in aggressive behavior when they were raised in an adverse environment (Cadoret et al., 1995; Caspi et al., 2002; Taylor and Kim-Cohen, 2007), other studies have failed to reproduce these results (Mednick et al., 1984; Willerman et al., 1992).”
Result
The neurobiology of maltreatment and adolescent violence
McCrory, E. J. P., & Viding, E. M. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60842-2 · Cited by 32
Violence and Men’s Health
Haegerich, T. M., & Hall, J. E. (2011) · American Journal of Lifestyle Medicine · doi:10.1177/1559827611410263 · Cited by 29
Towards the Prevention of Behavioural and Psychiatric Disorders in People with Intellectual Disabilities
Allen, D. G., Langthorne, P., Tonge, B. J., Emerson, E., McGill, P., Fletcher, R., Došen, A., & Kennedy, C. H. (2013) · Journal of Applied Research in Intellectual Disabilities · doi:10.1111/jar.12050 · Cited by 28
MAOA and male antisocial behavior: A review
Eme, R. F. (2013) · Aggression and Violent Behavior · doi:10.1016/j.avb.2013.02.001 · Cited by 32
Altered Functional Connectivity of Fronto-Cingulo-Striatal Circuits during Error Monitoring in Adolescents with a History of Childhood Abuse
Hart, H. C., Lim, L. L., Mehta, M. A., Curtis, C. J. C., Xu, X., Breen, G. D., Simmons, A., Mirza, K., & Rubia, K. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00007 · Cited by 27
“…(Olsson et al., 2005; Surtees et al., 2006; Chipman et al., 2007; Chorbov et al., 2007; Laucht et al., 2009) and with the low activity variant of the MAOA-uVNTR polymorphism (Caspi et al., 2002; Kim-Cohen et al., 2006; Cicchetti et al., 2007; Taylor and Kim-Cohen, 2007; Weder et al., 2009).”
Background
Nature, nurture and socioeconomic policy—What can we learn from molecular genetics?
Lundborg, P., & Stenberg, A. (2010) · Economics & Human Biology · doi:10.1016/j.ehb.2010.08.002 · Cited by 29
Imaging–Genetics Applications in Child Psychiatry
Pine, D. S., Ernst, M., & Leibenluft, E. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2009.12.022 · Cited by 24
Behavioral Genetics in Criminal and Civil Courts
Sabatello, M., & Appelbaum, P. S. (2017) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000141 · Cited by 28
The interaction between monoamine oxidase A (MAOA) and childhood maltreatment as a predictor of personality pathology in females: Emotional reactivity as a potential mediating mechanism
Byrd, A. L., Manuck, S. B., Hawes, S. W., Vebares, T. J., Nimgaonkar, V. L., Chowdari, K. V., Hipwell, A. E., Keenan, K. E., & Stepp, S. D. (2018) · Development and Psychopathology · doi:10.1017/s0954579417001900 · Cited by 29
Behavioral Biomarkers: What Are They Good For?
Baum, M. L., & Savulescu, J. (2013) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199844180.003.0002 · Cited by 23
Women and Girls with Psychopathic Characteristics
Nicholls, T. L., Odgers, C. L., & Cooke, D. J. (2008) · Wiley eBooks · doi:10.1002/9780470516157.ch21 · Cited by 22

Authors: Taylor, A., & Kim-Cohen, J.
Affiliations: King's College London (GB)
Yale University
Corresponding author: Taylor, Alan
Venue: Development and Psychopathology
Publisher: Cambridge University Press (CUP)
Published: 2007
Volume: 19
Issue: 4
Pages: 1029-1037
ISSN: 0954-5794 (ISSN-L)
1469-2198
DOI: 10.1017/s095457940700051x
OpenAlex: W2133897913
Cited by: 227
References: 56
Citations by year: 2025: 2 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 1 · 2020: 29 · 2019: 6 · 2018: 8 · 2017: 11 · 2016: 10 · 2015: 15 · 2014: 21 · 2013: 24 · 2012: 17
FWCI: 3.64
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 283 d)
Locations: Development and Psychopathology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords: gene-environment interaction, developmental psychopathology, monoamine oxidase A, MAOA gene, child abuse, antisocial behavior
MeSH terms: Adolescent, Adult, Antisocial Personality Disorder, Mental Disorders, Child, Child Abuse, Developmental Disabilities, Child, Preschool, Crime, Genotype, Humans, Infant, Longitudinal Studies, Monoamine Oxidase, Social Environment, Meta-Analysis as Topic, Odds Ratio, Conduct Disorder, Genetic Predisposition to Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Meta-analysis of gene–environment interactions in developmental psychopathology

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks