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Ten good reasons to consider biological processes in prevention and intervention research
Open accessAbstract
Most contemporary accounts of psychopathology acknowledge the importance of both biological and environmental influences on behavior. In developmental psychopathology, multiple etiological mechanisms for psychiatric disturbance are well recognized, including those operating at genetic, neurobiological, and environmental levels of analysis. However, neuroscientific principles are rarely considered in current approaches to prevention or intervention. In this article, we explain why a deeper understanding of the genetic and neural substrates of behavior is essential for the next generation of preventive interventions, and we outline 10 specific reasons why considering biological processes can improve treatment efficacy. Among these, we discuss (a) the role of biomarkers and endophenotypes in identifying those most in need of prevention; (b) implications for treatment of genetic and neural mechanisms of homotypic comorbidity, heterotypic comorbidity, and heterotypic continuity; (c) ways in which biological vulnerabilities moderate the effects of environmental experience; (d) situations in which Biology x Environment interactions account for more variance in key outcomes than main effects; and (e) sensitivity of neural systems, via epigenesis, programming, and neural plasticity, to environmental moderation across the life span. For each of the 10 reasons outlined we present an example from current literature and discuss critical implications for prevention.
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“As interactions between biology and environment sometimes explain more variance in outcomes than do main effects (Beauchaine et al., 2008), accounting for these neural factors can clarify why some adolescents may be more primed for good or bad outcomes given their combination of neural susceptibility and social-contextual exposures.”
From Adolescent neurobiological susceptibility to social context (2016) · cites this paper as Beauchaine et al., 2008
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Items 201–274 of 274
Direct and Passive Prenatal Nicotine Exposure and the Development of Externalizing Psychopathology
Gatzke‐Kopp, L. M., & Beauchaine, T. P. (2007) · Child Psychiatry & Human Development · doi:10.1007/s10578-007-0059-4 · Cited by 103
Self-citationPhenotypic and genetic complexity of psychosis
Craddock, N. J., O’Donovan, M. C., & Owen, M. J. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.033761 · Cited by 103
Reaching adolescents who drink harmfully: Fitting intervention to developmental reality
Masterman, P. W., & Kelly, A. B. (2003) · Journal of Substance Abuse Treatment · doi:10.1016/s0740-5472(03)00047-3 · Cited by 96
Plasticity for Affective Neurocircuitry: How the Environment Affects Gene Expression
Fox, N. A., Hane, A. A., & Pine, D. S. (2007) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2007.00464.x · Cited by 94
Brunelle, C., Assaad, J., Barrett, S. P., Ávila, C., Conrod, P., Tremblay, R. E., & Pihl, R. O. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000117859.23567.2e · Cited by 93
Davison, G. C. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.66.1.163 · Cited by 92
Maternal Programming of Defensive Responses Through Sustained Effects on Gene Expression
Meaney, M. J. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195306255.003.0007 · Cited by 92
The Developing Brain and Adolescent-Typical Behavior Patterns
SPEAR, L. P. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195306255.003.0001 · Cited by 92
The taxonicity of schizotypy: A replication.
Korfine, L., & Lenzenweger, M. F. (1995) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.104.1.26 · Cited by 90
A taxometric analysis of cognitive and neuromotor variables in children at risk for schizophrenia.
Erlenmeyer‐Kimling, L., Golden, R. R., & Cornblatt, B. A. (1989) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.98.3.203 · Cited by 89
Behavioral inhibition deficits in juvenile psychopaths
Roussy, S., & Toupin, J. (2000) · Aggressive Behavior · doi:10.1002/1098-2337(200011)26:6 · Cited by 89
Progress Review of the Psychosocial Treatment of Child Conduct Problems
Nock, M. K. (2003) · Clinical Psychology Science and Practice · doi:10.1093/clipsy.10.1.1 · Cited by 87
Tyrka, A. R., Cannon, T. D., Haslam, N., et al. (1995) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.104.1.173 · Cited by 85
Take Care to Do No Harm: Harmful Interventions for Youth Problem Behavior.
Rhule, D. M. (2005) · Professional Psychology Research and Practice · doi:10.1037/0735-7028.36.6.618 · Cited by 84
Ferdinand, R. F., Dieleman, G., Ormel, J., & Verhulst, F. C. (2007) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-006-9093-0 · Cited by 78 · cited 1×
“In addition to explaining homotypic comorbidity, central DA dysfunction likely also accounts for homotypic continuity, or the sequential development of different internalizing or externalizing disorders across the life span (see, e.g., Ferdinand et al., 2007).”
BackgroundLenzenweger, M. F., McLachlan, G. J., & Rubin, D. B. (2007) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.116.1.16 · Cited by 78
Comorbidity of Anxiety and Depression
Cloninger, C. R. (1990) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199006001-00009 · Cited by 77
Seeger, G., Schloss, P. D., Schmidt, M. H., Rüter-Jungfleisch, A., & Henn, F. A. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.05.049 · Cited by 75
New Developments in Prevention and Early Intervention for Alcohol Abuse in Youths
Stewart, S. H., Conrod, P., Marlatt, G. A., Comeau, M. N., Thush, C., & Krank, M. D. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000153547.34399.e8 · Cited by 71
Autism: Neural Basis and Treatment Possibilities
Charman, T. (2003) · Novartis Foundation symposium · doi:10.1002/0470869380 · Cited by 70
Davison, G. C. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.66.1.163 · Cited by 70
Deeper into the schizotypy taxon: On the robust nature of maximum covariance analysis.
Lenzenweger, M. F. (1999) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.108.1.182 · Cited by 68
Epigenetic approaches to developmental psychopathology
Goldsmith, H. H., Gottesman, I. I., & Lemery‐Chalfant, K. (1997) · Development and Psychopathology · doi:10.1017/s0954579497002095 · Cited by 68
The effect of nicotine on developing brain catecholamine systems
Heather, S. (1999) · Frontiers in bioscience · doi:10.2741/oliff · Cited by 67
Kane, V. B., Fu, Y., Matta, S. G., & Sharp, B. M. (2004) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.059899 · Cited by 66
Probabilistic Epigenesis of Psychopathology
Gottlieb, G., & Willoughby, M. T. (2015) · Wiley eBooks · doi:10.1002/9780470939383.ch17 · Cited by 65
Early Intervention and Brain Plasticity in Autism
Dawson, G., & Zanolli, K. M. (2003) · Novartis Foundation symposium · doi:10.1002/0470869380.ch16 · Cited by 64
Essential Genetics: A Genomics Perspective
Hartl, D. L. (1998) · Cited by 63
Deeper into the schizotypy taxon: On the robust nature of maximum covariance analysis.
Lenzenweger, M. F. (1999) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.108.1.182 · Cited by 63
El‐Sheikh, M. (2005) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.114.4.735 · Cited by 61
Conrod, P., & Stewart, S. H. (2005) · Journal of Cognitive Psychotherapy · doi:10.1891/088983905780907531 · Cited by 59
Dawes, R. M., & Meehl, P. E. (1966) · Psychological Bulletin · doi:10.1037/h0023584 · Cited by 58
Disinhibited Personality and Sensitivity to Alcohol Reinforcement
Conrod, P. J., Petersen, J., & Pihl, R. O. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb04455.x · Cited by 57
Bryant, R. A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.002 · Cited by 55
Maturational increases in c‐fos expression in the ascending dopamine systems
Andersen, S. L., Leblanc, C. J., & Lyss, P. J. (2001) · Synapse · doi:10.1002/syn.1091 · Cited by 55
Gatzke‐Kopp, L. M., & Beauchaine, T. P. (2007) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-006-9091-2 · Cited by 54
Self-citationA genetic analysis of ambulatory cardiorespiratory coupling
Kupper, N. H. M., Willemsen, G. A. H. M., Posthuma, D., de Boer, D., Boomsma, D. I., & de Geus, E. J. C. (2005) · Psychophysiology · doi:10.1111/j.1469-8986.2005.00276.x · Cited by 54
Schizotypy, taxometrics, and disconfirming theories in soft science
Beauchaine, T. P., Lenzenweger, M. F., & Waller, N. G. (2008) · Personality and Individual Differences · doi:10.1016/j.paid.2007.11.015 · Cited by 49
Self-citationHammock, E. A. D., & Levitt, P. R. (2006) · Human Development · doi:10.1159/000095581 · Cited by 46
Do psychotherapies produce neurobiological effects?
Kumari, V. (2006) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2006.00127.x · Cited by 45
Current Issues in the Psychopharmacology of Schizophrenia
Cheung, H. K. (2002) · Hong Kong journal of psychiatry · Cited by 42
Ross, R. G. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000046818.95464.42 · Cited by 41
Risk Factors for Conduct Problems and Depressive Symptoms in a Cohort of Ukrainian Children
Drabick, D. A. G., Beauchaine, T. P., Gadow, K. D., Carlson, G. A., & Bromet, E. J. (2006) · Journal of Clinical Child & Adolescent Psychology · doi:10.1207/s15374424jccp3502_8 · Cited by 41
Self-citationInsel, T. R., & Goodwin, F. K. (1983) · Psychiatric Services · doi:10.1176/ps.34.12.1131 · Cited by 39
Enhancing Outcomes in an Indicated Drug Prevention Program for High-Risk Youth
Thompson, E. A., Horn, M., Herting, J. R., & Eggert, L. L. (1997) · Journal of Drug Education · doi:10.2190/g6xy-u2cq-gfqf-pnev · Cited by 38
Current issues in the psychopharmacology of schizophrenia
Breier, A. F., Tran, P., Herrera, J. M., Tollefson, G. D., & Bymaster, F. P. (2001) · Lippincott Williams & Wilkins eBooks · Cited by 38
Conrod, P., & Stewart, S. H. (2005) · Journal of Cognitive Psychotherapy · doi:10.1891/jcop.2005.19.3.261 · Cited by 38
Cognitive and affective neuroscience and developmental psychopathology
Cicchetti, D., & Posner, M. I. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050273 · Cited by 36
Mental Illness Is NOT “an Illness Like Any Other”
Albee, G. W., & Joffe, J. M. (2004) · The Journal of Primary Prevention · doi:10.1023/b:jopp.0000024799.04666.8b · Cited by 35
Commentary: Gene-Environment Interplay in the Context of Genetics, Epigenetics, and Gene Expression
Kramer, D. A. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000145804.30112.6b · Cited by 35
Comorbidity between dysthymic and major depressive disorders: A family study analysis
Donaldson, S. K., Klein, D. N., Riso, L. P., & Schwartz, J. E. (1997) · Journal of Affective Disorders · doi:10.1016/s0165-0327(96)00106-1 · Cited by 29
Outcome with desipramine therapy in subtypes of nonpsychotic major depression
Coryell, W. H., & Turner, R. (1985) · Journal of Affective Disorders · doi:10.1016/0165-0327(85)90094-1 · Cited by 28
Cicchetti, D. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000466 · Cited by 28
Genetic and environmental influences on juvenile antisocial behaviour assessed on two occasions
Jacobson, K. C., Prescott, C. A., & Kendler, K. S. (2000) · Psychological Medicine · doi:10.1017/s0033291799002780 · Cited by 28
Disinhibited Personality and Sensitivity to Alcohol Reinforcement
Conrod, P., Petersen, J. B., & Pihl, R. O. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-199710000-00024 · Cited by 27
Beauchaine, T. P., & Marsh, P. (2015) · Wiley eBooks · doi:10.1002/9780470939383.ch23 · Cited by 26
Self-citationCompetence, Resilience, and Development in Adolescence
Masten, A. S. (2007) · doi:10.1093/acprof:oso/9780195306255.003.0002 · Cited by 25
Porges, S. W. (2006) · Development and Psychopathology · doi:10.1017/s0954579406060457 · Cited by 23
Neurocognitive and Physiological Prerequisites for Prevention of Adolescent Drug Abuse
Fishbein, D. H., Hyde, C., Coe, B., & Paschall, M. J. (2004) · The Journal of Primary Prevention · doi:10.1023/b:jopp.0000024802.72523.b9 · Cited by 23
Modifying Brain Networks Underlying Self-Regulation
Rueda, M. R., Rothbart, M. K., Saccomanno, L., & Posner, M. I. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195306255.003.0018 · Cited by 23
Cocaine during adolescence enhances dopamine in response to a natural reinforcer
Catlow, B. J., & Kirstein, C. L. (2006) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2006.11.007 · Cited by 22
Gatzke‐Kopp, L. M., & Beauchaine, T. P. (2007) · Cited by 21
Self-citationTowards an epigenetic approach to experimental criminology: The 2004 Joan McCord Prize Lecture
Tremblay, R. E. (2005) · Journal of Experimental Criminology · doi:10.1007/s11292-005-3542-6 · Cited by 14
Preventing a Non-Existent Illness?: Some Issues in the Prevention of “Schizophrenia”
Boyle, M. (2004) · The Journal of Primary Prevention · doi:10.1023/b:jopp.0000024801.34886.a7 · Cited by 13
Genetic Vulnerabilities to the Development of Psychopathology
Lemery‐Chalfant, K., & Doelger, L. (2005) · Sage eBooks · doi:10.4135/9781452231655.n7 · Cited by 11
Psychedelic drug flashbacks: Attentional deficits?
Matefy, R. E., Hayes, C., & Hirsch, J. (1979) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.88.2.212 · Cited by 10
Klein‐Heßling, J., & Lohaus, A. (2002) · Anxiety Stress & Coping · doi:10.1080/1061580021000020734 · Cited by 10
Ames, S. L., & McBride, C. M. (2006) · Evaluation & the Health Professions · doi:10.1177/0163278706290407 · Cited by 9
Early Identification and Prevention of Early-Onset Bipolar Disorder
Chang, K., Gallelli, K. A., & Howe, M. E. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195306255.003.0014 · Cited by 8
You'd Have to Be Sick Not to Be Crazy
Silvestri, A. J., & Joffe, J. M. (2004) · The Journal of Primary Prevention · doi:10.1023/b:jopp.0000024803.84954.69 · Cited by 3
Joffe, J. M. (2004) · The Journal of Primary Prevention · doi:10.1023/b:jopp.0000024919.81908.39 · Cited by 2
Schizophrenia: Evidence for Conceptualising It as a Brain Disease
Agrawal, N., & Hirsch, S. R. (2004) · The Journal of Primary Prevention · doi:10.1023/b:jopp.0000024800.41204.26 · Cited by 1
Flagged first, then by citations
Research works printed but not linked: 18
- Beauchaine, 2008, Child psychopathology: Genetic, neurobiological, and environmental substrates, 58
- Perry, 2008, Child psychopathology: Genetic, neurobiological, and environmental substrates, 93
- 10.2741/a472 · DOI
- Thorndike, 1911, Animal intelligence
- 10.1037/0893-164x.14.3.243 · DOI
- Beauchaine, 2008, Child psychopathology: Genetic, neurobiological, and environmental substrates, 129
- Gatzke-Kopp, 2007, Human behavior and the developing brain: Atypical development, 239
- 10.1037/0022-006x.60.3.426 · DOI
- Klein, 2008, Child and adolescent psychopathology, 477
- Beauchaine, 2006, Developmental psychopathology, 931
- Crowell, 2008, Child psychopathology: Genetic, neurobiological, and environmental substrates, 510
- DiClemente, 2001, Project MATCH: A priori matching hypotheses, results, and mediating mechanisms, 8, 239
- Beauchaine, 2006, Some recommendations for testing mediating and moderating effects in treatment-outcome research, International Journal of Psychology Research, 1, 1
- Fryer, 2008, Child psychopathology: Genetic, neurobiological, and environmental substrates, 180
- 10.1037/0021-843x.108.3.400 · DOI
- Fowles, 2006, Handbook of psychopathy, 14
- Hinshaw, 2003, Child psychopathology, 144
- Cicchetti, 2006, Developmental psychopathology: Vol. 2. Developmental neuroscience, 1
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Crowell, S. E., Beauchaine, T. P., & Linehan, M. M. (2009) · Psychological Bulletin · doi:10.1037/a0015616 · Cited by 1,292
Self-citationHeart rate variability as a transdiagnostic biomarker of psychopathology
Beauchaine, T. P., & Thayer, J. F. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.08.004 · Cited by 870
Self-citationResilience in Development: Progress and Transformation
Masten, A. S., & Cicchetti, D. (2016) · Developmental Psychopathology · doi:10.1002/9781119125556.devpsy406 · Cited by 416
Singh, I., & Rose, N. (2009) · Nature · doi:10.1038/460202a · Cited by 397
Future Directions in Emotion Dysregulation and Youth Psychopathology
Beauchaine, T. P. (2015) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2015.1038827 · Cited by 394
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Metadata
- Authors
- Beauchaine, T. P., Neuhaus, E., Brenner, S. L., & Gatzke-Kopp, L.
- Affiliations
- University of Washington (US)
- Corresponding author
- Beauchaine, Theodore P.
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008
- Volume
- 20
- Issue
- 3
- Pages
- 745-774
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- PMC
- PMC2690981
- OpenAlex
- W2172045957
- Cited by
- 215
- References
- 268
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 8 · 2021: 16 · 2020: 13 · 2019: 9 · 2018: 14 · 2017: 18 · 2016: 14 · 2015: 20 · 2014: 12 · 2013: 18 · 2012: 16
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH063699, MH63699)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- biological processes, prevention research, intervention research, developmental psychopathology, genetic etiology, neurobiological mechanisms, biomarkers, endophenotypes, psychiatric comorbidity, heterotypic continuity, gene-environment interaction, epigenesis, neuroplasticity, biological vulnerability, treatment efficacy
- MeSH terms
- Adolescent, Attention Deficit Disorder with Hyperactivity, Mental Disorders, Brain, Child, Child, Preschool, Depressive Disorder, Female, Humans, Infant, Infant, Newborn, Neuronal Plasticity, Phenotype, Pregnancy, Prenatal Exposure Delayed Effects, Psychopathology, Risk Factors, Schizophrenia, Schizophrenic Psychology, Social Environment, Neurotransmitter Agents, Twin Studies as Topic, Conduct Disorder, Genetic Predisposition to Disease, Early Diagnosis
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