Plasticity for Affective Neurocircuitry: How the Environment Affects Gene Expression

Fox, Nathan A.; Hane, Amie A.; Pine, Daniel S.

doi:10.1111/j.1467-8721.2007.00464.x

Cited by 94Neurotransmitter Receptor Influence on BehaviorChild and Adolescent Psychosocial and Emotional DevelopmentAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Plasticity for Affective Neurocircuitry: How the Environment Affects Gene Expression

Fox, Nathan A., Hane, Amie A., Pine, Daniel S.·2007·Current Directions in Psychological Science

DOI 10.1111/j.1467-8721.2007.00464.x

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Abstract

We ( Fox et al., 2005 ) recently described a gene-by-environment interaction involving child temperament and maternal social support, finding heightened behavioral inhibition in children homozygous or heterozygous for the serotonin transporter (5HTTLPR) gene short allele whose mothers reported low social support. Here, we propose a model, Plasticity for Affective Neurocircuitry, that describes the manner in which genetic disposition and environmental circumstances may interact. Children with a persistently fearful temperament (and the 5HTTLPR short allele) are more likely to experience caregiving environments in which threat is highlighted. This in turn will exacerbate an attention bias that alters critical affective neurocircuitry to threat and enhances and maintains anxious behavior in the child.

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Certain genes can confer environmentally sensitive plasticity, so the same genetic variant may increase risk under harmful conditions but provide benefit under favorable conditions.
“It is also possible for certain genes to confer environmentally sensitive “plasticity” such that the same genetic variant may confer risk under harmful environmental circumstances but provide benefit under auspicious conditions”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as Fox et al. 2007

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“Moreover, studies using experimental approaches, at least in adults, suggest that these attention biases are causally implicated in the genesis of anxiety following exposure to stress (MacLeod et al., 2002).”
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Authors: Fox, N. A., Hane, A. A., & Pine, D. S.
Affiliations: University of Maryland, College Park (US)
Williams College (US)
National Institutes of Health (US)
Corresponding author: Fox, Nathan A.
ORCID: Fox, Nathan A.
Hane, Amie A.
Pine, Daniel S.
Venue: Current Directions in Psychological Science
Publisher: SAGE Publications
Published: 2007-02
Volume: 16
Issue: 1
Pages: 1-5
ISSN: 0963-7214 (ISSN-L)
1467-8721
DOI: 10.1111/j.1467-8721.2007.00464.x
OpenAlex: W2160873692
Cited by: 94
References: 25
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 10 · 2012: 10
FWCI: 5.52
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Current Directions in Psychological Science (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: gene-environment interaction, serotonin transporter gene, 5-HTTLPR, child temperament, maternal social support, behavioral inhibition, fearfulness, attentional bias, threat processing, anxiety, care environment

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Plasticity for Affective Neurocircuitry: How the Environment Affects Gene Expression

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