Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: Implications for major depressive disorder

Tatro, Erick T.; Everall, Ian P.; Kaul, Marcus; Achim, Cristian L.

doi:10.1016/j.brainres.2009.06.036

Cited by 125Stress Responses and CortisolSignaling Pathways in DiseaseEstrogen and related hormone effects

Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: Implications for major depressive disorder

Open access

Tatro, Erick T., Everall, Ian P., Kaul, Marcus, Achim, Cristian L.·2009·Brain Research

DOI 10.1016/j.brainres.2009.06.036PMC PMC2724600

Open this paper in CoChat — free account

Abstract

Mood disorders associated with dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis are common psychiatric conditions. The glucocorticoid receptor (GR) is a steroid-activated nuclear receptor that, upon binding to cortisol, translocates to the nucleus where it targets genes related to neuronal metabolism and plasticity. In patients suffering from major depressive disorder (MDD), hypercortisolemia is a common finding. In the current study we investigated the molecular events associated with the FK506 binding proteins (FKBP) -52 and -51 response to cortisol exposure in neuronal cell cultures and their effect on GR translocation. We noted that FK506 altered nuclear localization of the GR and inhibited expression of GR-responsive genes. Furthermore, si-RNA knockdown of FKBP4 gene, coding for the immunophilin FKBP52, inhibited cortisol-activated GR nuclear translocation, while knockdown of FKBP5, coding for immunophilin FKBP51, was associated with increased baseline GR nuclear localization. We propose that immunophilins are modulators of the cortisol-HPA axis response to stress and related chronic brain disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.brainres.2009.06.036

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

FKBP51 inhibits GR ligand binding, nuclear translocation and transcriptional activity, while FKBP52 potentiates each of these activities.
“FKBP51 inhibits GR ligand binding, nuclear translocation and transcriptional activity, while FKBP52 potentiates each of these fundamental GR activities22–32.”
From Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor (2023) · cites this paper as [25]
The Introduction and Discussion report that FKBP52 promotes GR nuclear translocation and that FKBP51 knockdown increases baseline nuclear localization of GR in neurons. The cited passages do not establish that each protein has the claimed opposing effects on GR ligand binding or transcriptional activity; the Results measure a transcriptional effect of FK506 pretreatment, not of each protein separately. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measured
FKBP52 stabilizes ligand-bound GR, resulting in enhanced ligand affinity, and facilitates rapid GR nuclear translocation on dynein, allowing GR to proceed with dimerization and transcription activation.
“FKBP52 stabilizes ligand-bound GR, resulting in enhanced ligand affinity, and facilitates rapid GR nuclear translocation on dynein22,24,25,65, allowing GR to proceed with dimerization and transcription activation.”
From Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor (2023) · cites this paper as [25]
The Introduction says FKBP52 links GR to dynein, and reports that FKBP52 knockdown slowed cortisol-activated GR nuclear translocation; the Discussion describes FKBP52 as promoting a fast GR response. Our copy does not establish that FKBP52 enhances ligand affinity by stabilizing ligand-bound GR, or that it enables subsequent dimerization and transcription activation. The indexed passages have section labels but no page numbers. (LLM, conf=0.86)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis
Ozer, E. J., Best, S. R., Lipsey, T. L., & Weiss, D. S. (2003) · Psychological Bulletin · doi:10.1037/0033-2909.129.1.52 · Cited by 3,322 · see citing works
The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis
Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1986) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.38.cp21 · Cited by 2,287 · see citing works
Association of <emph type="ital">FKBP5</emph> Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults
Binder, E. B. (2008) · JAMA · doi:10.1001/jama.299.11.1291 · Cited by 1,362 · see citing works
Predictors of posttraumatic stress disorder and symptoms in adults: A meta-analysis.
Ozer, E. J., Best, S. R., Lipsey, T. L., & Weiss, D. S. (2008) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/1942-9681.s.1.3 · Cited by 1,252 · see citing works
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147 · see citing works
Clinical and Biochemical Manifestations of Depression
Gold, P. W., Goodwin, F. K., & Chrousos, G. P. (1988) · New England Journal of Medicine · doi:10.1056/nejm198808183190706 · Cited by 1,057 · see citing works
Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
Binder, E. B., Salyakina, D., Lichtner, P., Wochnik, G. M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M. A., et al. (2004) · Nature Genetics · doi:10.1038/ng1479 · Cited by 977 · see citing works
DNA binding site sequence directs glucocorticoid receptor structure and activity
Meijsing, S. H., Pufall, M. A., So, A. Y., Bates, D. L., Chen, L., & Yamamoto, K. R. (2009) · Science · doi:10.1126/science.1164265 · Cited by 673 · see citing works
FK506-binding Proteins 51 and 52 Differentially Regulate Dynein Interaction and Nuclear Translocation of the Glucocorticoid Receptor in Mammalian Cells
Wochnik, G. M., Rüegg, J., Abel, G. A., Schmidt, U., Holsboer, F., & Rein, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m407498200 · Cited by 638 · see citing works
Retinoic acid-induced differentiation of cultured human neuroblastoma cells: a comparison with phorbolester-induced differentiation
Påhlman, S., Ruusala, A.-I., Abrahamsson, L., Mattsson, M. E. K., & Esscher, T. (1984) · Cell Differentiation · doi:10.1016/0045-6039(84)90038-1 · Cited by 571 · see citing works
The stress system in depression and neurodegeneration: Focus on the human hypothalamus
Bao, A., Meynen, G., & Swaab, D. F. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.04.005 · Cited by 547 · see citing works
A New First Step in Activation of Steroid Receptors
Davies, T. H., Ning, Y.-M., & Sánchez, E. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100531200 · Cited by 427 · see citing works
Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders
Webster, M. J., Knable, M. B., O'Grady, J., Orthmann, J., & Weickert, C. S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001139 · Cited by 420 · see citing works
Silicon Graphics Inc.
Francis, B. (1993) · Datamation · Cited by 365 · see citing works
Polymorphisms of the Glucocorticoid Receptor Gene and Major Depression
van Rossum, E. F. C., Binder, E. B., Majer, M., Koper, J. W., Ising, M., Modell, S., Salyakina, D., Lamberts, S. W. J., & Holsboer, F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.007 · Cited by 324 · see citing works
Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes
Wang, J.-C., Derynck, M. K., Nonaka, D. F., Khodabakhsh, D. B., Haqq, C., & Yamamoto, K. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407008101 · Cited by 320 · see citing works
Pathophysiology of hypercortisolism in depression
Carroll, B. J., Cassidy, F., Naftolowitz, D., Tatham, N. E., Wilson, W. H., Iranmanesh, A., Liu, P. Y., & Veldhuis, J. D. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.00967.x · Cited by 317 · see citing works
Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls
Ising, M., Depping, A., Siebertz, A., Lucae, S., Unschuld, P. G., Kloiber, S. M., Horstmann, S., Uhr, M., Müller‐Myhsok, B., & Holsboer, F. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06332.x · Cited by 312 · see citing works
Loss of Glucocorticoid Fast Feedback in Depression
Young, E. A. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810320017003 · Cited by 299 · see citing works
Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement
Pratt, W. B., Galigniana, M. D., Harrell, J. M., & DeFranco, D. B. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.02.004 · Cited by 285 · see citing works
Opposing roles of type I and type II adrenal steroid receptors in hippocampal long-term potentiation
Pavlides, C., Watanabe, Y., Magarin˜os, A. M., & McEwen, B. S. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00151-8 · Cited by 261 · see citing works
Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes
Sinars, C. R., Cheung-Flynn, J., Rimerman, R. A., Scammell, J. G., Smith, D. F., & Clardy, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0231020100 · Cited by 254 · see citing works
Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: A putative post-traumatic stress disorder model
Kohda, K., Harada, K., Kato, K., Hoshino, A., Motohashi, J., Yamaji, T., Morinobu, S., Matsuoka, N., & Kato, N. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.041 · Cited by 252 · see citing works
Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
Tranguch, S., Cheung-Flynn, J., Daikoku, T., Prapapanich, V., Cox, M. B., Xie, H., Wang, H., Das, S. K., Smith, D. F., & Dey, S. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505775102 · Cited by 232 · see citing works
Glucocorticoid and Mineralocorticoid Receptor mRNA Expression in Rat Brain
Chao, H. M., Choo, P. H., & McEwen, B. S. (2008) · Neuroendocrinology · doi:10.1159/000125250 · Cited by 217 · see citing works
HSP56: a novel heat shock protein associated with untransformed steroid receptor complexes
Sanchez, E. R. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45667-0 · Cited by 214 · see citing works
Physiological role for the cochaperone FKBP52 in androgen receptor signaling
Cheung-Flynn, J., Prapapanich, V., Cox, M. B., Riggs, D. L., Suarez-Quian, C., & Smith, D. F. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0071 · Cited by 212 · see citing works
Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids
Hubler, T. R., & Scammell, J. G. (2004) · Cell Stress & Chaperones · doi:10.1379/csc-32r.1 · Cited by 201 · see citing works
Glucocorticoid Resistance in the Squirrel Monkey Is Associated with Overexpression of the Immunophilin FKBP511
Reynolds, P. D., Ruan, Y., Smith, D. F., & Scammell, J. G. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5429 · Cited by 184 · see citing works
Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children
Koenen, K. C., Saxe, G., Purcell, S., Smoller, J. W., Bartholomew, D. A., Miller, A. B., Hall, E., Kaplow, J. B., Enlow, M. B., Moulton, S. L., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001727 · Cited by 183 · see citing works
Differential Control of Glucocorticoid Receptor Hormone-Binding Function by Tetratricopeptide Repeat (TPR) Proteins and the Immunosuppressive Ligand FK506
Davies, T. H., Ning, Y.-M., & Sánchez, E. R. (2005) · Biochemistry · doi:10.1021/bi048503v · Cited by 180 · see citing works
Glucocorticoid hormone resistance during primate evolution: receptor-mediated mechanisms
Chrousos, G. P., Renquist, D., Brandon, D., Eil, C., Pugeat, M., Vigersky, R., Cutler, G. B., Loriaux, D. L., & Lipsett, M. B. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.6.2036 · Cited by 179 · see citing works
An immunophilin that binds M(r) 90,000 heat shock protein: main structural features of a mammalian p59 protein.
Callebaut, I., Renoir, J., Lebeau, M., Massol, N., Burny, A., Baulieu, E. E., & Mornon, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6270 · Cited by 167 · see citing works
3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex
Wu, B., Li, P., Liu, Y., Lou, Z., Ding, Y., Shu, C., Ye, S., Bartlam, M., Shen, B., & Rao, Z. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305969101 · Cited by 165 · see citing works
Proteasomal inhibition enhances glucocorticoid receptor transactivation and alters its subnuclear trafficking
Deroo, B. J., Rentsch, C., Sampath, S., Young, J., DeFranco, D. B., & Archer, T. K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4113-4123.2002 · Cited by 164 · see citing works
Molecular chaperones function as steroid receptor nuclear mobility factors
Elbi, C., Walker, D. A., Romero, G. G., Sullivan, W. P., Toft, D. O., Hager, G. L., & DeFranco, D. B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400116101 · Cited by 144 · see citing works
Glucocorticoids Exacerbate Hypoxic and Hypoglycemic Hippocampal Injury In Vitro: Biochemical Correlates and a Role for Astrocytes
Tombaugh, G. C., Yang, S. H., Swanson, R. A., & Sapolsky, R. M. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08884.x · Cited by 134 · see citing works
Evidence for glucocorticoid receptor transport on microtubules by dynein
Harrell, J. M., Murphy, P. J. M., Morishima, Y., Chen, H., Mansfield, J. F., Galigniana, M. D., & Pratt, W. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406863200 · Cited by 129 · see citing works
Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors: Models for depression and anxiety?
Gass, P., Reichardt, H. M., Strekalova, T. V., Henn, F. A., & Tronche, F. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00518-2 · Cited by 117 · see citing works
Binding of hsp90-associated immunophilins to cytoplasmic dynein: direct binding and in vivo evidence that the peptidylprolyl isomerase domain is a dynein interaction domain
Galigniana, M. D., Harrell, J. M., Murphy, P. J. M., Chinkers, M., Radanyi, C., Renoir, J.-M., Zhang, M., & Pratt, W. B. (2002) · Biochemistry · doi:10.1021/bi020399z · Cited by 117 · see citing works
FK506-Binding Protein 51 Regulates Nuclear Transport of the Glucocorticoid Receptor β and Glucocorticoid Responsiveness
Zhang, X., Clark, A. F., & Yorio, T. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1279 · Cited by 116 · see citing works
Pituitary-Adrenal Function in the Squirrel Monkey
Brown, G. M., Grota, L. J., Penney, D. P., & Reichlin, S. (1970) · Endocrinology · doi:10.1210/endo-86-3-519 · Cited by 100 · see citing works
Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors
Giraudier, S., Chagraoui, H., Komura, E., Barnache, S., Blanchet, B., Couedic, J. P. L., Smith, D. F., Larbret, F., Taksin, A., Moreau-Gachelin, F., et al. (2002) · Blood · doi:10.1182/blood-2002-02-0485 · Cited by 77 · see citing works
Control of glucocorticoid and progesterone receptor subcellular localization by the ligand-binding domain is mediated by distinct interactions with tetratricopeptide repeat proteins
Banerjee, A., Periyasamy, S., Wolf, I. M., Hinds, T. D., Yong, W., Shou, W., & Sanchez, E. R. (2008) · Biochemistry · doi:10.1021/bi8011862 · Cited by 73 · see citing works
BCL-xL Regulates Synaptic Plasticity
Jonas, E. A. (2006) · Molecular Interventions · doi:10.1124/mi.6.4.7 · Cited by 72 · see citing works
Squirrel Monkey Immunophilin FKBP51 Is a Potent Inhibitor of Glucocorticoid Receptor Binding1
Denny, W. B., Valentine, D. L., Reynolds, P. D., Smith, D. F., & Scammell, J. G. (2000) · Endocrinology · doi:10.1210/en.141.11.4107 · Cited by 66 · see citing works
Hippocampal type I and type II corticosteroid receptors are modulated by central noradrenergic systems
Maccari, S., Mormède, P., Piazza, P., `mon, H., Angelucci, L., & Moal, M. L. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90049-d · Cited by 62 · see citing works
The Microtubule-Associated Protein Doublecortin-Like Regulates the Transport of the Glucocorticoid Receptor in Neuronal Progenitor Cells
Fitzsimons, C. P., Ahmed, S., Wittevrongel, C. F. W., Schouten, T. G., Dijkmans, T. F., Scheenen, W. J. J. M., Schaaf, M. J. M., de Kloet, E. R., & Vreugdenhil, E. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0233 · Cited by 52 · see citing works
Role of molecular chaperones in subnuclear trafficking of glucocorticoid receptors
DeFranco, D. B. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00957.x · Cited by 50 · see citing works
Reserpine-Induced Decrease in Type I and II Corticosteroid Receptors in Neuronal and Lymphoid Tissues of Adrenalectomized Rats
Lowy, M. T. (2008) · Neuroendocrinology · doi:10.1159/000125336 · Cited by 49 · see citing works
Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits
Gawlik, M., Möller-Ehrlich, K., Mende, M., Jovnerovski, M., Jung, S., Jabs, B. E., Knapp, M., & Stoeber, G. (2006) · BMC Psychiatry · doi:10.1186/1471-244x-6-52 · Cited by 43 · see citing works
Glucocorticoid Receptors in Hippocampal Neurons that Do Not Engage Proteasomes Escape from Hormone-Dependent Down-Regulation but Maintain Transactivation Activity
Wang, X., Pongrac, J. L., & DeFranco, D. B. (2002) · Molecular Endocrinology · doi:10.1210/me.2001-0287 · Cited by 43 · see citing works
The Proinflammatory Cytokine, Interleukin-1α, Reduces Glucocorticoid Receptor Translocation and Function1
Pariante, C. M., Pearce, B. D., Pisell, T. L., Sanchez, C. I., Po, C., Su, C., & Miller, A. H. (1999) · Endocrinology · doi:10.1210/en.140.9.4359 · Cited by 40 · see citing works
The immunosuppressant drug FK506 is a potent trophic agent for human fetal neurons
Avramut, M., Zeevi, A., & Achim, C. L. (2001) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00307-8 · Cited by 38 · see citing works
Self-citation
Mice that under- or overexpress glucocorticoid receptors as models for depression or posttraumatic stress disorder
Chourbaji, S., Vogt, M. A., & Gass, P. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)67005-8 · Cited by 27 · see citing works
Neuron-Enriched Second Trimester Human Cultures: Growth Factor Response and in Vivo Graft Survival
White, M. G., Hammond, R. R., Sanders, V. J., Bonaroti, E. A., Mehta, A. P., Wang, G., Wiley, C. A., & Achim, C. L. (1999) · Cell Transplantation · doi:10.1177/096368979900800115 · Cited by 24 · see citing works
Self-citation
Corticosteroid Receptor Transgenic Mice
Urani, A., & Gass, P. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1286.037 · Cited by 21 · see citing works
Effect of immunosuppressive agents on glucocorticoid receptor function in A6 cells
Edinger, R. S., Watkins, S. C., Pearce, D., & Johnson, J. P. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00337.2001 · Cited by 8 · cited 4× · see citing works
“On the other hand the evidence whether FK506 would enhance or inhibit nuclear translocation of the GR is still conflicting (Edinger et al., 2002).”
BackgroundInfluential
Changes induced in the central nervous system of rats by steroid drug
Miyakawa, T., Sumiyoshi, S., & Deshimaru, M. (1974) · Acta Neuropathologica · doi:10.1007/bf00685325 · Cited by 5 · see citing works

Flagged first, then by citations

2 of the 61 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Limited AS 2008 Antibody Review to Mouse Anti FKBP51 ab46002 Vol., ed.∧eds AbCam Incorporated Cambridge, MA
Tatro ET 2008 Immunophilins FKBP52 and FKBP51 Modulate Glucocorticoid Receptor Distribution in Neurons and are Altered in HIV and Major Depressive Disorder [Dissertation] Cellular and Molecular Pathology University of Pittsburgh School of Medicine Pittsburgh, PA 210

Sorted by citations

Scaling tree-based automated machine learning to biomedical big data with a feature set selector
Le, T. T., Fu, W., & Moore, J. H. (2019) · Bioinformatics · doi:10.1093/bioinformatics/btz470 · Cited by 456 · see citing works
Eating ourselves to death (and despair): The contribution of adiposity and inflammation to depression
Shelton, R. C., & Miller, A. H. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.004 · Cited by 257 · see citing works
Prenatal stress and epigenetics
Cao-Lei, L., de Rooij, S. R., King, S., Matthews, S. G., Metz, G. A. S., Roseboom, T. J., & Szyf, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.016 · Cited by 230 · see citing works
The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress
Hartmann, J., Wagner, K. V., Liebl, C., Scharf, S. H., Wang, X.-D., Wolf, M., Hausch, F., Rein, T., Schmidt, U., Touma, C., et al. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.041 · Cited by 224 · see citing works
Pharmacogenetics in major depression: A comprehensive meta-analysis
Niitsu, T., Fabbri, C., Bentini, F., & Serretti, A. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.05.011 · Cited by 192 · see citing works
Steroid up-regulation of FKBP51 and its role in hormone signaling
Jääskeläinen, T., Makkonen, H., & Palvimo, J. J. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.04.006 · Cited by 167 · see citing works
The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum
Piechota, M., Korostyński, M., Solecki, W., Gieryk, A., Ślęzak, M., Bilecki, W., Ziółkowska, B., Kostrzewa, E., Cymerman, I. A., Swiech, L. J., et al. (2010) · Genome biology · doi:10.1186/gb-2010-11-5-r48 · Cited by 159 · see citing works
Stress-induced sex differences: Adaptations mediated by the glucocorticoid receptor
Bourke, C. H., Harrell, C. S., & Neigh, G. N. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.024 · Cited by 158 · see citing works
Checks and balances: The glucocorticoid receptor and NFĸB in good times and bad
Bekhbat, M., Rowson, S. A., & Neigh, G. N. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.05.001 · Cited by 133 · see citing works
Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease
Salminen, A., Ojala, J. O., Kaarniranta, K., Hiltunen, M., & Soininen, H. S. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.10.006 · Cited by 129 · see citing works
Childhood adversity and epigenetic regulation of glucocorticoid signaling genes: Associations in children and adults
Tyrka, A. R., Ridout, K. K., & Parade, S. H. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000870 · Cited by 119 · see citing works
The emerging role of peptidyl‐prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease
Blair, L. J., Baker, J. D., Sabbagh, J. J., & Dickey, C. A. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13033 · Cited by 120 · see citing works
Childhood maltreatment and methylation of FK506 binding protein 5 gene (FKBP5)
Tyrka, A. R., Ridout, K. K., Parade, S. H., Paquette, A., Marsit, C. J., & Seifer, R. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000991 · Cited by 118 · see citing works
Targeting Hsp90 and its co-chaperones to treat Alzheimer’s disease
Blair, L. J., Sabbagh, J. J., & Dickey, C. (2014) · Expert opinion on therapeutic targets · doi:10.1517/14728222.2014.943185 · Cited by 113 · see citing works
Hypothalamic Regulation of Corticotropin-Releasing Factor under Stress and Stress Resilience
Kageyama, K., Iwasaki, Y., & Daimon, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212242 · Cited by 104 · see citing works
Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries
Martinez, G. J., Appleton, M., Kipp, Z. A., Loria, A. S., Min, B., & Hinds, T. D. (2023) · Physiological Reviews · doi:10.1152/physrev.00021.2023 · Cited by 107 · see citing works
FKBP5 polymorphism is associated with major depression but not with bipolar disorder
Szczepankiewicz, A., Leszczyńska-Rodziewicz, A., Pawlak, J., Narozna, B., Rajewska-Rager, A., Wilkosc, M., Zaremba, D., Maciukiewicz, M., & Twarowska-Hauser, J. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.002 · Cited by 100 · see citing works
Biological Actions of the Hsp90-binding Immunophilins FKBP51 and FKBP52
Zgajnar, N. R., Leo, S. A. D., Lotufo, C. M., Erlejman, A. G., Piwien‐Pilipuk, G., & Galigniana, M. D. (2019) · Biomolecules · doi:10.3390/biom9020052 · Cited by 94 · see citing works
Depression, fatigue and neurocognitive deficits in chronic hepatitis C
Yeoh, S. W., Holmes, A., Saling, M. M., Everall, I., & Nicoll, A. (2018) · Hepatology International · doi:10.1007/s12072-018-9879-5 · Cited by 93 · see citing works
Self-citation
Regulation of the glucocorticoid response to stress‐related disorders by the Hsp90‐binding immunophilin FKBP51
Galigniana, N. M., Ballmer, L. T., Toneatto, J., Erlejman, A. G., Lagadari, M., & Galigniana, M. D. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07775.x · Cited by 75 · see citing works
Genetics of childhood and adolescent depression: insights into etiological heterogeneity and challenges for future genomic research
Rice, F. J. (2010) · Genome Medicine · doi:10.1186/gm189 · Cited by 75 · see citing works
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor
Noddings, C. M., Johnson, J. L., & Agard, D. A. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01128-y · Cited by 75 · see citing works
“FKBP52 stabilizes ligand-bound GR, resulting in enhanced ligand affinity, and facilitates rapid GR nuclear translocation on dynein 22,24,25,65 , allowing GR to proceed with dimerization and transcription activation.”
Background
Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric Disease
Baker, J. D., McMillan, I. O., Ospina, S. R., Gulick, D., & Blair, L. J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010079 · Cited by 73 · see citing works
Altered Functional Protein Networks in the Prefrontal Cortex and Amygdala of Victims of Suicide
Kékesi, K. A., Juhász, G. D., Simor, A., Gulyássy, P., Szegő, É. M., Hunyadi‐Gulyás, É., Darula, Z., Medzihradszky, K. F., Palkovits, M., Penke, B., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050532 · Cited by 72 · see citing works
Glucocorticoid-independent modulation of GR activity: Implications for immunotherapy
Hapgood, J. P., Avenant, C., & Moliki, J. M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.06.002 · Cited by 72 · see citing works
The glucocorticoid receptor–FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder
Li, H., Su, P., Lai, T. K. Y., Jiang, A., Liu, J., Zhai, D., Campbell, C., Lee, F. H. F., Yong, W., Pasricha, S., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci130363 · Cited by 73 · see citing works
Understanding epigenetic architecture of suicide neurobiology: A critical perspective
Roy, B., & Dwivedi, Y. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.031 · Cited by 69 · see citing works
Association of FKBP5 gene haplotypes with completed suicide in the Japanese population
Supriyanto, I., Sasada, T., Fukutake, M., Asano, M., Ueno, Y., Nagasaki, Y., Shirakawa, O., & Hishimoto, A. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.019 · Cited by 67 · see citing works
Neurotrophins, inflammation and oxidative stress as illness activity biomarkers in bipolar disorder
Pfaffenseller, B., Fries, G. R., Wollenhaupt-Aguiar, B., Colpo, G. D., Stertz, L., Panizzutti, B., Magalhães, P. V., & Kapczinski, F. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.811981 · Cited by 68 · see citing works
A Functional riboSNitch in the 3′ Untranslated Region ofFKBP5Alters MicroRNA-320a Binding Efficiency and Mediates Vulnerability to Chronic Post-Traumatic Pain
Linnstaedt, S. D., Riker, K. D., Rueckeis, C. A., Kutchko, K. M., Lackey, L., McCarthy, K. R., Tsai, Y.-H., Parker, J. S., Kurz, M. C., Hendry, P. L., et al. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.3458-17.2018 · Cited by 66 · see citing works
Icariin alters the expression of glucocorticoid receptor, FKBP5 and SGK1 in rat brains following exposure to chronic mild stress
Wei, K., XU, Y., Zhao, Z., Wu, X., Du, Y., Sun, J., Yi, T., Dong, J., & Liu, B. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2591 · Cited by 66 · see citing works
Dose- and time-dependent glucocorticoid receptor signaling in podocytes
Guess, A. J., Agrawal, S., Wei, C., Ransom, R. F., Benndorf, R., & Smoyer, W. E. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00161.2010 · Cited by 65 · see citing works
FK506 binding protein 51 integrates pathways of adaptation
Rein, T. (2016) · BioEssays · doi:10.1002/bies.201600050 · Cited by 65 · see citing works
Control of Alzheimer's Amyloid Beta Toxicity by the High Molecular Weight Immunophilin FKBP52 and Copper Homeostasis in Drosophila
Sanokawa‐Akakura, R., Cao, W., Allan, K., Patel, K., Ganesh, A., Heiman, G. A., Burke, R., Kemp, F. W., Bogden, J. D., Camakaris, J., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008626 · Cited by 62 · see citing works
FKBP5 genetic variation
Ellsworth, K. A., Moon, I., Eckloff, B. W., Fridley, B. L., Jenkins, G. D., Batzler, A. J., Biernacka, J. M., Abo, R., Brisbin, A. G., Ji, Y., et al. (2013) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e32835dc133 · Cited by 60 · see citing works
The role of hypothalamus–pituitary–adrenal genes and childhood trauma in borderline personality disorder
Martín‐Blanco, A., Ferrer, M., Soler, J., Arranz, M. J., Vega, D., Calvo, N., Elices, M., Sánchez‐Mora, C., Iris Garcia-martinez, A., Salazar, J., et al. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-015-0612-2 · Cited by 58 · see citing works
GLUCOCORTICOID RECEPTOR-RELATED GENES: GENOTYPE AND BRAIN GENE EXPRESSION RELATIONSHIPS TO SUICIDE AND MAJOR DEPRESSIVE DISORDER: Research Article: Glucocorticoid Receptor-Related Genes and Suicide
Yin, H., Galfalvy, H., Pantazatos, S. P., Huang, Y.-Y., Rosoklija, G. B., Dwork, A. J., Burke, A., Arango, V., Oquendo, M. A., & Mann, J. J. (2016) · Depression and Anxiety · doi:10.1002/da.22499 · Cited by 57 · see citing works
Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice
Criado‐Marrero, M., Gebru, N. T., Blazier, D. M., Gould, L. A., Baker, J. D., Beaulieu‐Abdelahad, D., & Blair, L. J. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01159-w · Cited by 51 · see citing works
Neuroendocrine Stress System in Bipolar Disorder
Juruena, M. F., Cleare, A. J., & Young, A. H. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_184 · Cited by 51 · see citing works
Hyperactivity of the hypothalamus–pituitary–adrenal axis in lipopolysaccharide-induced neurodevelopmental model of schizophrenia in rats: Effects of antipsychotic drugs
Basta‐Kaim, A., Budziszewska, B., Leśkiewicz, M., Fijał, K., Regulska, M., Kubera, M., Wędzony, K., & Lasoń, W. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.09.083 · Cited by 48 · see citing works
Deficiency of FK 506‐binding protein ( FKBP ) 51 alters sleep architecture and recovery sleep responses to stress in mice
Albu, S., Romanowski, C. P. N., Curzi, M. L., Jakubcakova, V., Flachskamm, C., Gassen, N. C., Hartmann, J., Schmidt, M. V., Schmidt, U., Rein, T., et al. (2013) · Journal of Sleep Research · doi:10.1111/jsr.12112 · Cited by 49 · see citing works
Identification and replication of RNA-Seq gene network modules associated with depression severity
Le, T. T., Savitz, J. B., Suzuki, H., Misaki, M., Teague, T. K., White, B. C., Marino, J. H., Wiley, G. B., Gaffney, P. M., Drevets, W. C., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0234-3 · Cited by 47 · see citing works
FKBP5 and early life stress affect the hippocampus by an age-dependent mechanism
Criado‐Marrero, M., Smith, T. M., Gould, L. A., Kim, S., Penny, H. J., Sun, Z., Gulick, D., Dickey, C. A., & Blair, L. J. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100143 · Cited by 42 · see citing works
Ectopic MicroRNA-150-5p Transcription Sensitizes Glucocorticoid Therapy Response in MM1S Multiple Myeloma Cells but Fails to Overcome Hormone Therapy Resistance in MM1R Cells
Palagani, A., de Beeck, K. O., Naulaerts, S., Diddens, J., Chirumamilla, C. S., Camp, G. V., Laukens, K., Heyninck, K., Gerlo, S., Mestdagh, P., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113842 · Cited by 43 · see citing works
Depletion of FKBP51 in Female Mice Shapes HPA Axis Activity
Hoeijmakers, L., Harbich, D., Schmid, B., Lucassen, P. J., Wagner, K. V., Schmidt, M. V., & Hartmann, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095796 · Cited by 41 · see citing works
Systemic virus distribution and host responses in brain and intestine of chickens infected with low pathogenic or high pathogenic avian influenza virus
Post, J., Burt, D. W., Cornelissen, J. B. W. J., Broks, V., van Zoelen, D., Peeters, B. P. H., & Rebel, J. M. J. (2012) · Virology Journal · doi:10.1186/1743-422x-9-61 · Cited by 40 · see citing works
Role of glucocorticoid- and monoamine-metabolizing enzymes in stress-related psychopathological processes
Tseilikman, V., Dremencov, E., Tseilikman, O., Pavlovičová, M., Lacinová, Ľ., & Jezova, D. (2020) · Stress · doi:10.1080/10253890.2019.1641080 · Cited by 35 · see citing works
Blood-based gene expression signatures of medication-free outpatients with major depressive disorder: integrative genome-wide and candidate gene analyses
Hori, H., Sasayama, D., Teraishi, T., Yamamoto, N., Nakamura, S., Ota, M., Hattori, K., Kim, Y., Higuchi, T., & Kunugi, H. (2016) · Scientific Reports · doi:10.1038/srep18776 · Cited by 38 · see citing works
Short-term withdrawal from developmental exposure to cocaine activates the glucocorticoid receptor and alters spine dynamics
Caffino, L., Giannotti, G., Malpighi, C., Racagni, G., & Fumagalli, F. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.05.002 · Cited by 36 · see citing works
Gender Differences in Cortisol and Cortisol Receptors in Depression: A Narrative Review
Teo, C. H., Wong, A. C. H., Sivakumaran, R. N., Parhar, I. S., & Soga, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087129 · Cited by 35 · see citing works
Functions of the Hsp90-Binding FKBP Immunophilins
Guy, N. C., Garcia, Y. A., Sivils, J. C., Galigniana, M. D., & Cox, M. B. (2014) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-319-11731-7_2 · Cited by 35 · see citing works
Gene expression profiling in brain of mice exposed to the marine neurotoxin ciguatoxin reveals an acute anti-inflammatory, neuroprotective response
Ryan, J. C., Morey, J. S., Bottein, M. D., Ramsdell, J. S., & Dolah, F. M. V. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-107 · Cited by 33 · see citing works
The FKBP5 Gene Affects Alcohol Drinking in Knockout Mice and Is Implicated in Alcohol Drinking in Humans
Qiu, B., Luczak, S. E., Wall, T. L., Kirchhoff, A. M., Xu, Y., Eng, M. Y., Stewart, R. B., Shou, W., Boehm, S. L., Chester, J. A., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081271 · Cited by 30 · see citing works
Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive- Associated Abnormal Uterine Bleeding
Kayisli, O. G., Kayisli, U. A., Başar, M., Semerci, N., Schatz, F., & Lockwood, C. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137855 · Cited by 29 · see citing works
The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51
Antunica-Noguerol, M., Budziñski, M. L., Druker, J., Gassen, N. C., Sokn, C., Senin, S. A., Aprile-Garcia, F., Holsboer, F., Rein, T., Liberman, A. C., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.44 · Cited by 29 · see citing works
Nucleocytoplasmic shuttling of the glucocorticoid receptor is influenced by tetratricopeptide repeat-containing proteins
Mazaira, G. I., Echeverria, P. C., & Galigniana, M. (2020) · Journal of Cell Science · doi:10.1242/jcs.238873 · Cited by 21 · see citing works
Unraveling the Role of Peptidyl-Prolyl Isomerases in Neurodegeneration
Gérard, M., Deleersnijder, A., Demeulemeester, J., Debyser, Z., & Baekelandt, V. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8184-2 · Cited by 29 · see citing works
Dynamic expression of FKBP5 in the medial prefrontal cortex regulates resiliency to conditioned fearPreprint
Criado-Marrero, M., Silva, R. J. M., Velázquez, B., Hernández, A., Colón, M., Cruz, E., Soler-Cedeño, O., & Porter, J. (2017) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.043000.116 · Cited by 28 · see citing works
Perinatal stress and epigenetics.
(2021) · Handbook of Clinical Neurology · doi:10.1016/b978-0-12-820107-7.00008-2 · Cited by 28 · see citing works
Cytokine secretion from brain macrophages infected with human immunodeficiency virus in vitro and treated with raltegravir
Tatro, E. T., Soontornniyomkij, B., Letendre, S. L., & Achim, C. L. (2014) · BMC Infectious Diseases · doi:10.1186/1471-2334-14-386 · Cited by 27 · see citing works
Self-citation
Effects of RU486 in Treatment of Traumatic Stress-Induced Glucocorticoid Dysregulation and Fear-Related Abnormalities: Early versus Late Intervention
Lin, C.-C., Cheng, P., Hsiao, M., & Liu, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105494 · Cited by 25 · see citing works
Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus–infected individuals
Tatro, E. T., Nguyen, T. B., Bousman, C., Masliah, E., Grant, I., Atkinson, J. H., & Everall, I. (2010) · Journal of NeuroVirology · doi:10.3109/13550284.2010.504248 · Cited by 23 · see citing works
Self-citation
Loss of FKBP5 impedes adipocyte differentiation under both normoxia and hypoxic stress
Zhang, L., Qiu, B., Wang, T., Wang, J., Liu, M. R., Xu, Y., Wang, C., Deng, R., Williams, K. E., Yang, Z., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.02.126 · Cited by 23 · see citing works
Regulation of FKBP51 and FKBP52 functions by post-translational modifications
Daneri-Becerra, C., Zgajnar, N. R., Lotufo, C. M., Ramos-Hryb, A. B., Piwien‐Pilipuk, G., & Galigniana, M. D. (2019) · Biochemical Society Transactions · doi:10.1042/bst20190334 · Cited by 23 · see citing works
Examining FKBP5 mRNA expression in human iPSC-derived neural cells
Lieberman, R., Kranzler, H. R., Levine, E. S., & Covault, J. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.11.027 · Cited by 18 · see citing works
Differential Effects of Fkbp4 and Fkbp5 on Regulation of the Proopiomelanocortin Gene in Murine AtT-20 Corticotroph Cells
Kageyama, K., Iwasaki, Y., Watanuki, Y., Niioka, K., & Daimon, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115724 · Cited by 19 · see citing works
Adverse maternal environment and western diet impairs cognitive function and alters hippocampal glucocorticoid receptor promoter methylation in male mice
Ke, X., Fu, Q., Sterrett, J., Hillard, C. J., Lane, R. H., & Majnik, A. V. (2020) · Physiological Reports · doi:10.14814/phy2.14407 · Cited by 19 · see citing works
The physiology of stress and the human body’s response to stress
Lee, R. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823039-8.00017-4 · Cited by 19 · see citing works
FKBP52 in Neuronal Signaling and Neurodegenerative Diseases: A Microtubule Story
Chambraud, B., Byrne, C., Méduri, G., Baulieu, E. E., & Giustiniani, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031738 · Cited by 18 · see citing works
RCAN1 Is an Important Mediator of Glucocorticoid-Induced Apoptosis in Human Leukemic Cells
Nagao, K., Iwai, Y., & Miyashita, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049926 · Cited by 18 · see citing works
Tricyclic antidepressants target FKBP51 SUMOylation to restore glucocorticoid receptor activity
Budziñski, M. L., Sokn, C., Gobbini, R., Ugo, B., Antunica-Noguerol, M., Senin, S., Bajaj, T., Gassen, N. C., Rein, T., Schmidt, M. V., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01491-0 · Cited by 17 · see citing works
Understanding the Neuroepigenetic Constituents of Suicide Brain
Roy, B., & Dwivedi, Y. (2018) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2018.01.007 · Cited by 17 · see citing works
Corticosteroid receptors as a model for the Hsp90•immunophilin-based transport machinery
Mazaira, G. I., Pilipuk, G. P., & Galigniana, M. D. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.07.005 · Cited by 17 · see citing works
HIV-1 proteins accelerate HPA axis habituation in female rats
Panagiotakopoulos, L., Kelly, S. D., & Neigh, G. N. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.02.011 · Cited by 15 · see citing works
Early Life Stress Alters Expression of Glucocorticoid Stress Response Genes and Trophic Factor Transcripts in the Rodent Basal Ganglia
Tran, C. H., Weickert, C. S., Weickert, T. W., & Sinclair, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105333 · Cited by 14 · see citing works
FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model
Criado‐Marrero, M., Gebru, N. T., Gould, L. A., Blazier, D. M., Vidal-Aguiar, Y., Smith, T. M., Abdelmaboud, S. S., Shelton, L. B., Wang, X., Dahrendorff, J., et al. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00062-x · Cited by 14 · see citing works
Decoding the transcriptional programs activated by psychotropic drugs in the brain
Zygmunt, M., Piechota, M., Parkitna, J. M. R., & Korostyński, M. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12511 · Cited by 13 · see citing works
Construction and Validation of a 13-Gene Signature for Prognosis Prediction in Medulloblastoma
Li, C., Zou, H., Xiong, Z., Xiong, Y., Miyagishima, D. F., Wanggou, S., & Li, X. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00429 · Cited by 13 · see citing works
Regulators of glucocorticoid receptor function in an animal model of depression and obesity
Kurek, A., Głombik, K., Detka, J., Basta‐Kaim, A., Kubera, M., Lasoń, W., & Budziszewska, B. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12591 · Cited by 12 · see citing works
Enhanced Human Decidual Cell–Expressed FKBP51 May Promote Labor-Related Functional Progesterone Withdrawal
Schatz, F., Guzeloglu‐Kayisli, O., Başar, M., Buchwalder, L. F., Ocak, N., Güzel, E., Guller, S. M., Semerci, N., Kayisli, U. A., & Lockwood, C. J. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.05.014 · Cited by 11 · see citing works
Male-specific effects of lipopolysaccharide on glucocorticoid receptor nuclear translocation in the prefrontal cortex of depressive rats
Brkic, Z., Petrovic, Z., Franic, D., Mitić, M., & Adžić, M. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4374-y · Cited by 11 · see citing works
Distinct modifications of hippocampal glucocorticoid receptor phosphorylation and FKBPs by lipopolysaccharide in depressive female and male rats
Brkic, Z., Francija, E., Petrovic, Z., Franic, D., Lukić, I., Mitić, M., & Adžić, M. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725914 · Cited by 11 · see citing works
Association between polymorphisms of FKBP5 gene and suicide attempt in a Mexican population: A case-control study
Hernández‐Díaz, Y., González‐Castro, T. B., Tovilla‐Zárate, C. A., Juárez‐Rojop, I. E., López‐Narváez, M. L., Pérez‐Hernández, N., Rodrı́guez-Pérez, J. M., & Mendoza, A. D. G. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.11.002 · Cited by 11 · see citing works
Knocking out Fkbp51 decreases CCl4-induced liver injury through enhancement of mitochondrial function and Parkin activity
Qiu, B., Zhong, Z., Dou, L., Xu, Y., Zou, Y., Weldon, K. S., Wang, J., Zhang, L., Liu, M., Williams, K. E., et al. (2024) · Cell & Bioscience · doi:10.1186/s13578-023-01184-3 · Cited by 10 · see citing works
Impact of FKBP52 on cell proliferation and hormone‐dependent cancers
Hanaki, S., & Shimada, M. (2023) · Cancer Science · doi:10.1111/cas.15811 · Cited by 7 · see citing works
Genetic Influences on Depression and Anxiety in Childhood and Adolescence
Rice, F. J. (2014) · Springer eBooks · doi:10.1007/978-1-4614-9509-3_3 · Cited by 9 · see citing works
Synergistic Effects of Calcineurin Inhibitors and Steroids on Steroid Sensitivity of Peripheral Blood Mononuclear Cells
Takeuchi, H., Iwamoto, H., Nakamura, Y., Hirano, T., Konno, O., Kihara, Y., Chiba, N., Yokoyama, T., Takano, K., Toraishi, T., et al. (2015) · Cell Medicine · doi:10.3727/215517914x681802 · Cited by 8 · see citing works
Influence of Early Family Cohesion on Future Orientation
Zheng, L., & Gan, Y. (2018) · Journal of Individual Differences · doi:10.1027/1614-0001/a000260 · Cited by 7 · see citing works
SUMO conjugation as regulator of the glucocorticoid receptor-FKBP51 cellular response to stress
Liberman, A. C., Budziñski, M. L., Sokn, C., Gobbini, R. P., Ugo, M. B., & ARZT, E. S. (2019) · Steroids · doi:10.1016/j.steroids.2019.108520 · Cited by 7 · see citing works
Chronic adolescent stress alters GR-FKBP5 interactions in the hippocampus of adult female rats
Rowson, S. A., Bekhbat, M., Kelly, S. D., Hyer, M. M., Dyer, S. K., Weinshenker, D., & Neigh, G. N. (2024) · Stress · doi:10.1080/10253890.2024.2312467 · Cited by 6 · see citing works
Intact Recognition Memory and Altered Hippocampal Glucocorticoid Receptor Signaling in Fkbp5-deficient Mice Following Acute Uncontrollable Stress
Jeon, Y.-J., Choi, B., Park, M., Jang, Y.-S., Yoon, S. J., Lyoo, I. K., & Han, J. (2023) · Experimental Neurobiology · doi:10.5607/en23006 · Cited by 5 · see citing works
A novel role for the immunophilin FKBP52 in motor coordination.
Young, M. J., Geiszler, P. C., & Pardon, M.-C. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.015 · Cited by 5 · see citing works
Neuroendocrine and stress pathways in bipolar disorders
Juruena, M. F., Cleare, A. J., & Young, A. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821398-8.00018-7 · Cited by 4 · see citing works
Peroxiredoxin 6 Knockout Mice Demonstrate Anxiety Behavior and Attenuated Contextual Fear Memory after Receiving Acute Immobilization Stress
Phasuk, S., Varinthra, P., Nitjapol, A., Bandasak, K., & Liu, I. Y. (2021) · Antioxidants · doi:10.3390/antiox10091416 · Cited by 4 · see citing works
Role of the Hsp90-Immunophilin Heterocomplex in Cancer Biology
Leo, S. A. D., Zgajnar, N. R., Mazaira, G. I., Erlejman, A. G., & Galigniana, M. D. (2019) · Current Cancer Therapy Reviews · doi:10.2174/1573394715666190102120801 · Cited by 4 · see citing works
Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases
Daneri-Becerra, C., Ciucci, S. M., Mazaira, G. I., & Galigniana, M. D. (2021) · Current Drug Targets · doi:10.2174/1389450121999201230204320 · Cited by 4 · see citing works
Functions of the Hsp90-Binding FKBP Immunophilins
Ortiz, N. R., Guy, N. C., Garcia, Y. A., Sivils, J. C., Galigniana, M. D., & Cox, M. B. (2022) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-14740-1_2 · Cited by 3 · see citing works
The transportosome system as a model for the retrotransport of soluble proteins
Mazaira, G. I., Erlejman, A. G., Zgajnar, N. R., Piwien‐Pilipuk, G., & Galigniana, M. D. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.112047 · Cited by 3 · see citing works
Dissecting the Long-Term Effect of Stress Early in Life on FKBP5: The Role of miR-20b-5p and miR-29c-3p
Cattane, N., Benedetto, M. G. D., D’Aprile, I., Riva, M. A., & Cattaneo, A. (2024) · Biomolecules · doi:10.3390/biom14030371 · Cited by 3 · see citing works
NFAT activation by FKBP52 promotes cancer cell proliferation by suppressing p53
Hanaki, S., Habara, M., Tomiyasu, H., Sato, Y., Miki, Y., Masaki, T., Shibutani, S., & Shimada, M. (2024) · Life Science Alliance · doi:10.26508/lsa.202302426 · Cited by 3 · see citing works

IMMUNOPHILINS FKBP52 AND FKBP51 MODULATE GLUCOCORTICOID RECEPTOR DISTRIBUTION IN NEURONS AND ARE ALTERED IN HIV AND MAJOR DEPRESSIVE DISORDER
Tatro, E. T. (2008) · D-Scholarship@Pitt (University of Pittsburgh)
Self-citation
The Role of FKBP51 in the regulation of the glucocorticoid receptor
Wochnik, G. M., Binder, E. B., Salyakina, D., Kohli, M. A., Kloiber, S. M., Holsboer, F., & Rein, T. (2005) · Pharmacopsychiatry · doi:10.1055/s-2005-918877
Accumulation of Cytoplasmic Glucocorticoid Receptor Is Related to Elevation of FKBP5 in Lymphocytes of Depressed Patients
Lukić, I., Mitić, M., Soldatović, I., Jovicic, M. J., Marić, N. P., Radulović, J., & Adžić, M. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0451-z · Cited by 27 · see citing works
Glucocorticoid Receptor and FKBP5 Expression Is Altered Following Exposure to Chronic Stress: Modulation by Antidepressant Treatment
Guidotti, G., Calabrese, F., Anacker, C., Racagni, G., Pariante, C. M., & Riva, M. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.225 · Cited by 200 · see citing works
Regulation of the glucocorticoid response to stress‐related disorders by the Hsp90‐binding immunophilin FKBP51
Galigniana, N. M., Ballmer, L. T., Toneatto, J., Erlejman, A. G., Lagadari, M., & Galigniana, M. D. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07775.x · Cited by 75 · see citing works

Authors: Tatro, E. T., Everall, I. P., Kaul, M., & Achim, C. L.
Affiliations: University of Pittsburgh (US)
University of California San Diego (US)
Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Tatro, Erick T.
ORCID: Everall, Ian P.
Kaul, Marcus
Venue: Brain Research
Publisher: Elsevier BV
Published: 2009-08
Volume: 1286
Pages: 1-12
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2009.06.036
PMC: PMC2724600
OpenAlex: W2000320359
Semantic Scholar: ae62fcaaab9cb7f8eb6e5a37d39b2b7868c8dc1d
Cited by: 125
References: 61
Citations by year: 2026: 2 · 2024: 8 · 2023: 8 · 2022: 10 · 2021: 11 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 14 · 2015: 8 · 2014: 9 · 2013: 4 · 2012: 5
FWCI: 2.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Center for AIDS Research, University of Washington
University of California, San Diego
National Institute of Mental Health (R01MH079881, P30MH62512, MH076681, R41MH079728, R25MH074508, R21MH076681, R25MH081482, P30MH062512)
National Institute of Allergy and Infectious Diseases (AI-36214, P30AI036214)
National Institute of Neurological Disorders and Stroke (R01NS050621)
National Institute of Biomedical Imaging and Bioengineering (T32EB001026)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: glucocorticoid receptor, nuclear translocation, FKBP51, FKBP52, FKBP4, immunophilins, major depressive disorder, hypothalamic-pituitary-adrenal axis, cortisol, hypercortisolism, neuronal gene expression, stress response, siRNA knockdown
MeSH terms: Tacrolimus Binding Protein 5, Cells, Cultured, Depressive Disorder, Major, Major Depressive Disorder, Fluorescent Antibody Technique, Gene Expression Regulation, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Neurons, Pituitary-Adrenal System, Receptors, Glucocorticoid, Gene Expression, Protein Transport, Tacrolimus Binding Proteins, RNA, Small Interfering

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: Implications for major depressive disorder

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks