Increased Prevalence of Functional Gastrointestinal Disorders in Panic Disorder: Clinical and Theoretical Implications
Abstract
Background Functional gastrointestinal disorders (FGID) are a group of disorders characterized by recurrent gastrointestinal distress for which no structural or biochemical cause can be discerned. Irritable bowel syndrome (IBS) is an FGID estimated to affect 10% to 25% of the United States population. IBS occurs in over 40% of individuals with panic disorder, and in patients with IBS, 25% to 30% have panic disorder, which has led to speculation about possible shared pathophysiology between the two. Less is known about the prevalence of other FGID in individuals with panic disorder. Objective The purpose of this study was to examine the prevalence of IBS and all the other FGID in patients with current Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) panic disorder. Introduction We assessed FGIDs in 73 treatment-seeking DSM-IV panic disorder patients via the Diagnostic Interview Questions for Functional Gastrointestinal Disorders and made descriptive comparisons with a large convenience sample from an already-completed United States Household Survey (USHS), which employed the same diagnostic criteria. Results The prevalence of IBS and other FGIDs in both men and women with panic disorder were substantially higher than in the USHS respondents. Women with panic disorder had significantly more functional chest pain than men, but there was no gender difference in IBS. With the exception of functional anorectal and biliary disorders, the FGID prevalence…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The mean number of FGIDs was 3.9 in the panic disorder group.
“The mean number of FGIDs was 3.9 in the panic disorder group, so the co-morbidity encompasses many FGIDs and not only IBS.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [50]
Lydiard reported higher rates of IBS and other FGIDs in panic disorder patients than in the general public.
“Lydiard assessed FGID in 73 panic disorder patients and compared these rates to the United States Household Survey.7 He reported higher rates of IBS and other FGIDs in these patients than in the general public.50”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [50]
Cites
Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
Tsigos, C., & Chrousos, G. P. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00429-4 · Cited by 2,822 · see citing works
Drossman, D. A., Li, Z., Andruzzi, E., Temple, R. D., Talley, N. J., Grant Thompson, W., Whitehead, W. E., Janssens, J., Funch-Jensen, P., Corazziari, E., et al. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303162 · Cited by 2,198 · see citing works
AGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384 · see citing works
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116 · see citing works
Sexual and physical abuse in women with functional or organic gastrointestinal disorders
Drossman, D. A., Leserman, J., Nachman, G., Li, Z., Gluck, H., Toomey, T. C., & Mitchell, C. M. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-11-828 · Cited by 898 · see citing works
Psychosocial Factors in the Irritable Bowel Syndrome
Drossman, D. A., McKee, D. C., Sandler, R. S., Mitchell, C. M., Cramer, E. M., Lowman, B. C., & Burger, A. L. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80017-9 · Cited by 757 · see citing works
Drossman, D. A., Toner, B. B., Whitehead, W. E., Diamant, N. E., Dalton, C. B., Duncan, S., Emmott, S., Proffitt, V., Akman, D., Frusciante, K., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00669-3 · Cited by 614 · see citing works
Symptoms of Psychologic Distress Associated With Irritable Bowel Syndrome
Whitehead, W. E., Bosmajian, L., Zonderman, A. B., Costa Jr., P. T., & Schuster, M. M. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80018-0 · Cited by 480 · see citing works
Roy-Byrne, P. P., Stang, P., Wittchen, H.-U., Ustun, B., Walters, E. E., & Kessler, R. C. (2000) · British Journal of Psychiatry · doi:10.1192/bjp.176.3.229 · Cited by 446 · see citing works
Level of chronic life stress predicts clinical outcome in irritable bowel syndrome
Bennett, E. J., Tennant, C. C., Piesse, C., Badcock, C.-A., & Kellow, J. E. (1998) · Gut · doi:10.1136/gut.43.2.256 · Cited by 405 · see citing works
The Pain of Being Sick: Implications of Immune-to-Brain Communication for Understanding Pain
Watkins, L. R., & Maier, S. F. (2000) · Annual Review of Psychology · doi:10.1146/annurev.psych.51.1.29 · Cited by 388 · see citing works
Licinio, J., & Wong, M.-L. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000586 · Cited by 380 · see citing works
Associations between anxiety disorders and physical illness
H�rter, M. C., Conway, K. P., & Merikangas, K. R. (2003) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-003-0449-y · Cited by 297 · see citing works
Mearin, X. B. (2001) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520152584770 · Cited by 240 · see citing works
Miller, A. H., Pariante, C. M., & Pearce, B. D. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_7 · Cited by 203 · see citing works
Talley, N. J., Boyce, P. M., & Jones, M. (1998) · Gut · doi:10.1136/gut.42.1.47 · Cited by 154 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Anxiety disorders and comorbid medical illness
Roy-Byrne, P. P., Davidson, K. W., Kessler, R. C., Asmundson, G. J. G., Goodwin, R. D., Kubzansky, L., Lydiard, R. B., Massie, M. J., Katon, W., Laden, S. K., et al. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.12.006 · Cited by 668 · see citing works
Self-citationFadgyas-Stanculete, M., Buga, A.-M., Popa-Wagner, A., & Dumitrascu, D. L. (2014) · Journal of Molecular Psychiatry · doi:10.1186/2049-9256-2-4 · Cited by 197 · see citing works
zarate, N., farmer, A. D., grahame, R., mohammed, S. D., knowles, C. H., scott, S. M., & aziz, Q. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01421.x · Cited by 178 · see citing works
Sperber, A. D., & Dekel, R. (2010) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2010.16.2.113 · Cited by 85 · see citing works
- Authors
- Lydiard, R. B.
- Affiliations
- University of South Carolina (US)
- Corresponding author
- Lydiard, R. Bruce
- Venue
- CNS Spectrums
- Publisher
- Cambridge University Press (CUP)
- Published
- 2005-11
- Volume
- 10
- Issue
- 11
- Pages
- 899-908
- ISSN
- 1092-8529 (ISSN-L)
- 2165-6509
- OpenAlex
- W2137628305
- Cited by
- 45
- References
- 16
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 4 · 2013: 4 · 2012: 1
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS Spectrums (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- functional gastrointestinal disorders, panic disorder, irritable bowel syndrome, prevalence, comorbidities, functional chest pain, shared pathophysiology, corticotropin-releasing factor, sex differences
- MeSH terms
- Adult, Cross-Sectional Studies, Female, Gastrointestinal Diseases, Humans, Male, Middle Aged, Comorbidity, Panic Disorder, Irritable Bowel Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
