Pattern of neurobehavioral deficits associated with interferon alfa therapy for leukemia
Abstract
We evaluated the neuropsychological and personality profiles of 25 patients with chronic myelogenous leukemia treated with interferon alfa (IFN-alpha). This group of persons performed well below expectation on tests of cognitive speed, verbal memory, and executive functions. Personality changes included depression, increased somatic concern, and stress reactions. A control group of leukemia patients not treated with IFN-alpha had significantly better cognitive speed and mood. The pattern of cognitive and personality changes in patients receiving IFN-alpha is highly suggestive of frontal-subcortical brain dysfunction.
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Leukemia patients receiving IFN-α treatment showed deficits on the Trail Making Test part B.
“Leukemia patients receiving IFN-α treatment showed deficits on the TMT part B (Pavol et al., 1995)”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Pavol et al., 1995
Several studies found no effect of IFN-α treatment on verbal fluency.
“Similarly, several studies found no effect of IFN-α treatment on verbal fluency (Amodio et al., 2005; Fontana et al., 2007; Pavol et al., 1995)”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Pavol et al., 1995
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- Authors
- Pavol, M. A., Meyers, C. A., Rexer, J. L., Valentine, A. D., Mattis, P. J., & Talpaz, M.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Venue
- Neurology
- Published
- 1995-05
- Volume
- 45
- Issue
- 5
- Pages
- 947-950
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2165822654
- Cited by
- 160
- References
- 0
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 2 · 2022: 2 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 3
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Hematology › Chronic Myeloid Leukemia Treatments
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Keywords
- interferon-alpha, chronic myeloid leukemia, neurobehavioral deficits, neuropsychological assessment, personality change, depression, somatic symptoms, stress reactions, cognitive speed, verbal memory, executive function
- MeSH terms
- Adult, Aged, Behavior, Cognition, Emotions, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Personality, Personality Tests, Psychomotor Performance, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Interferon-alpha
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