Structural Brain Correlations of Visuospatial and Visuoperceptual Tests in Parkinson’s Disease
Open accessAbstract
Background: Diagnosis of mild cognitive impairment in Parkinson’s disease (PD) is relevant because it is a marker for evolution to dementia. However, the selection of suitable tests to evaluate separate cognitive domains in mild cognitive impairment related to PD remains an open question. The current work aims to investigate the neuroanatomical correlates of several visuospatial/visuoperceptual tests using the same sample and a multimodal MRI approach. Methods: The study included 36 PD patients and 20 healthy subjects matched for age, sex, and education. The visuospatial/visuoperceptual tests selected were: Pentagon Copying Test (PCT), Judgment of Line Orientation Test (JLOT), Visual Form Discrimination Test (VFDT), Facial Recognition Test (FRT), Symbol Digit Modalities Test (SMDT), and clock copying task (CLOX2). FreeSurfer was used to assess cortical thickness, and tract-based spatial statistics was used for fractional anisotropy analysis. Results: Lower performance in the PCT, JLOT, and SDMT was associated with extensive cortical thickness reductions in lateral parietal and temporal regions. VFDT and CLOX2 did not show this common pattern and correlated with more limited medial occipito-temporal and occipito-parietal regions. Performance in all visuospatial/visuoperceptual tests correlated with fractional anisotropy in the corpus callosum. Conclusions: Our findings show that JLOT, SDMT, and PCT, in addition to differentiating patients from controls, are suitable visuospatial/visuoperceptual tests to reflect cortical thinning in lateral temporo-parietal regions in PD patients. We did not observe the dissociation between dorsal and ventral streams that was expected according to the neuropsychological classification of visuospatial and visuoperceptual tests. (JINS, 2018, 24, 33–44)
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Changing the line orientation in the MMN task is a process known to involve specific parietal regions.
“changing the line orientation in our MMN task is a process known to involve specific parietal regions34”
From Deviations in effective connectivity explain different hallucination subtypes in Parkinson's disease psychosis (2026) · cites this paper as [34]
The Results (page not provided) link performance on the Judgment of Line Orientation Test to cortical thickness in specific parietal regions, including the precuneus and supramarginal gyrus, in patients with Parkinson’s disease. The paper does not study changing a line’s orientation in an MMN task, and a structural correlation does not establish that those regions are involved in that process. (LLM, conf=0.86)
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“…strong results for the dorsal pathway in the source reconstruction analysis we focused on one dorsal model, using source reconstruction results, and the literature on the Benton line judgment task and the neural anatomy of the dorsal pathway 34 to define the dipoles (Supplementary Information 11).”
- Authors
- Garcia-Diaz, A. I., Segura, B., Baggio, H. C., Marti, M. J., Valldeoriola, F., Compta, Y., Bargallo, N., Uribe, C., Campabadal, A., Abos, A., & Junque, C.
- Affiliations
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Universitat de Barcelona (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Venue
- Journal of the International Neuropsychological Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2017-07-17
- Volume
- 24
- Issue
- 1
- Pages
- 33-44
- ISSN
- 1355-6177 (ISSN-L)
- 1469-7661
- PMC
- PMC5851059
- OpenAlex
- W2734826538
- Cited by
- 39
- References
- 45
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 1
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of the International Neuropsychological Society (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion)
- Funders
- Fundació la Marató de TV3 (20142310)
- Generalitat de Catalunya (2014 SGR 98, 20142310, 2014SGR)
- Ministerio de Economía y Competitividad (PSI2013-41393-P, BES-2014-068173)
- European Social Fund (PSI2013-41393-P)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- Parkinson's disease, mild cognitive impairment, neuroanatomical correlates, cortical thickness, fractional anisotropy, corpus callosum, temporoparietal cortex, dorsal and ventral visual streams, Symbol Digit Modalities Test, face recognition (cognition)
- MeSH terms
- Aged, Cerebral Cortex, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease, Space Perception, Visual Perception, Cohort Studies, Diffusion Tensor Imaging, Cognitive Dysfunction
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