The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Fruits and vegetables in the prevention of cancer and cardiovascular disease
Open accessAbstract
OBJECTIVE: We quantified the public health benefit of fruits and vegetables on the prevention of cancer and cardiovascular disease (CVD), using currently available human data. DESIGN: We reviewed over 250 observational studies on cancer and CVD. Relative risks (RRs) for high versus low intake of fruits and vegetables were obtained. The preventable proportion of chronic diseases, i.e. the per cent of cases attributable to low consumption of fruits and vegetables, was estimated using three scenarios: best guess, optimistic (using stronger RRs) and conservative (using weaker RRs and eliminating the contribution of smoking and/or drinking). The preventable proportion was calculated for increasing average intake from the current 250 g day(-1) to the recommended 400 g day(-1) among the general Dutch population. RESULTS: It is estimated that in the Netherlands cancer incidence could be reduced by 19% (12,000 cases annually, best guess), ranging from 6% (conservative) to 28% (optimistic). Cardiovascular deaths could be reduced by 16% (8000 deaths annually, best guess), ranging from 6% to 22%. Evidence is most abundant for gastrointestinal cancers, followed by hormone-related cancers, but limited for other sites and CVD. CONCLUSIONS: Increasing consumption of fruits and vegetables carries a large public health potential. Population trials and biological mechanisms should eventually provide scientific proof of their efficacy. The available evidence is sufficient to justify public health education and promotion aimed at a substantial increase in the consumption of fruits and vegetables.
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“Increased consumption of fruits and vegetables is associated with a reduction of the risk of cardiovascular disease [72,73,74].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [73]
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Cites
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Doll, R., & Peto, R. (1981) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/66.6.1192 · Cited by 3,927
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Peto, R. (1983) · Springer eBooks · doi:10.1007/978-1-4757-1117-2_30 · Cited by 3,504
Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence.
Block, G., Patterson, B. H., & Subar, A. (1992) · Nutrition and Cancer · doi:10.1080/01635589209514201 · Cited by 3,321
Fruit and vegetables, and cardiovascular disease: A review
Ness, A. R., & Powles, J. W. (1997) · International Journal of Epidemiology · doi:10.1093/ije/26.1.1 · Cited by 1,368
Vegetables, fruit, and cancer. I. Epidemiology
Steinmetz, K. A., & Potter, J. D. (1991) · Cancer Causes and Control · doi:10.1007/bf00051672 · Cited by 1,118
Vegetables, fruit, and cancer. II. Mechanisms
Steinmetz, K. A., & Potter, J. D. (1991) · Cancer Causes and Control · doi:10.1007/bf00054304 · Cited by 804
Kleihues, P., McGregor, D., & Stewart, B. W. (1996) · Medical Entomology and Zoology · Cited by 92
Fruits and Vegetables in chronic disease prevention
Klerk, M., Jansen, M., Veer, P. V. ’., & Kok, F. J. (1998) · Socio-Environmental Systems Modeling · Cited by 29
Self-citationThe role of chemoprevention in cancer control.
Greenwald, P., & Gj, K. (1996) · PubMed · Cited by 28
Research works printed but not linked: 3
- Tomatis, 1990, Cancer: Causes, Occurences and Control
- Kistemake, 1993, De Consumptie Van Groepen Voedingsmiddelen door Nederlandse Bevolkingsgroepen
- 3 Margetts BM , Thompson R , Duffy S on behalf of the Nutritional Epidemiology Working Group on Diet and Cancer. A Review of the Epidemiological Literature Linking Fruit and Vegetable Consumption to Risk of Cancer 1994.
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Bioactive compounds and antioxidant capacities of 18 non-traditional tropical fruits from Brazil
Rufino, M. D. S. M., Alves, R. E., de Brito, E. S., Pérez‐Jiménez, J., Saura-Calixto, F. D., & Mancini-Filho, J. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.01.037 · Cited by 1,504
Bazzano, L. A., He, J., Ogden, L. G., Loria, C. M., Vupputuri, S., Myers, L., & Whelton, P. K. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.1.93 · Cited by 1,035
Joshi, P., Islam, S., Pais, P. S., Reddy, S., Prabhakaran, D., Kazmi, K. A., Pandey, M. R., Haque, S., Mendis, S., Rangarajan, S., et al. (2007) · JAMA · doi:10.1001/jama.297.3.286 · Cited by 1,038
Edible berries: Bioactive components and their effect on human health
Nile, S. H., & Park, S. W. (2013) · Nutrition · doi:10.1016/j.nut.2013.04.007 · Cited by 890
Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
Quach, A., Levine, M. E., Tanaka, T., Lu, A. T., Chen, B. H., Ferrucci, L., Ritz, B., Bandinelli, S., Neuhouser, M. L., Beasley, J. M., et al. (2017) · Aging · doi:10.18632/aging.101168 · Cited by 801
Metadata
- Authors
- van't Veer, P., Jansen, M. C., Klerk, M., & Kok, F. J.
- Affiliations
- National Institute for Public Health and the Environment (NL)
- Wageningen University & Research (NL)
- ORCID
- Kok, Frans J
- Venue
- Public Health Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2000-03
- Volume
- 3
- Issue
- 1
- Pages
- 103-107
- ISSN
- 1368-9800 (ISSN-L)
- 1475-2727
- OpenAlex
- W2170476987
- Cited by
- 362
- References
- 9
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 4 · 2023: 10 · 2022: 7 · 2021: 11 · 2020: 14 · 2019: 14 · 2018: 12 · 2017: 14 · 2016: 17 · 2015: 23 · 2014: 17 · 2013: 36 · 2012: 23
- FWCI
- 12.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Public Health Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- fruits and vegetables, cancer prevention, cardiovascular disease, dietary intake, relative risk, gastrointestinal cancer, hormone-dependent tumors, cardiovascular mortality, public health benefits, dietary recommendations, Netherlands
- MeSH terms
- Cardiovascular Diseases, Diet, Fruit, Humans, Neoplasms, Netherlands, Public Health, Risk Factors, Vegetables
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