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Cited by 16Neurotransmitter Receptor Influence on BehaviorTryptophan and brain disordersNeural and Behavioral Psychology Studies

Selective effects of simultaneous monoamine depletion on mood and emotional responsiveness

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Hughes, Jay-Maree, Matrenza, Cathy, Kemp, Andrew H., Harrison, Ben J., Liley, David, Nathan, Pradeep J.·2004·The International Journal of Neuropsychopharmacology
DOI 10.1017/s1461145703003845
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Abstract

Monoamines play a significant role in the regulation of mood and emotion. While the selective effects of serotonin and catecholamine depletion on mood have been described, the effects of simultaneous monoamine depletion on subjective measures of mood and emotional responsiveness are yet to be examined. The current study aimed to investigate the effects of simultaneous monoamine depletion on mood and emotional responsiveness in healthy participants. Twenty female participants completed a randomized, double-blind, placebo-controlled study, under a balanced control condition (B), and a combined monoamine depletion condition (CMD; via tryptophan, tyrosine and phenylalanine depletion). Mood ratings Visual Analogue Mood Scale (VAMS) and Profile Of Mood States (POMS) and measures of emotional responsiveness (Emotional Stroop and International Affective Picture System) were examined at baseline and 5 h post-depletion. Following CMD, participants rated themselves as feeling sadder, more antagonistic, and mentally slower on three VAMS subscales. There were no significant mood changes found on the POMS or measures of emotional responsiveness. These findings suggest that simultaneous depletion of all monoamines may have selective effects on mood. The findings provide evidence that the simultaneous monoamine depletion technique may be a useful experimental method to probe central monoamine function in humans.

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Crossref · 10.1017/s1461145703003845

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  • One study found no effect of combined lowering of plasma tryptophan, phenylalanine and tyrosine on valence or arousal ratings of IAPS in female volunteers.

    “Recognition of emotion in pictures has not been widely studied; one study found no effect of combined lowering of plasma tryptophan, phenylalanine and tyrosine on valence or arousal ratings of IAPS in female volunteers (Hughes et al., 2004) and a further study requiring participants to choose between different intensities of an emotion without explicitly identifying the emotion found no effect of”

    From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Hughes et al., 2004

  • Three studies using the emotional Stroop found no effect of ATD or combined depletion on reaction times.

    “Three studies using the emotional Stroop found no effect of ATD or combined tryptophan, phenylalanine and tyrosine depletion on reaction times (Evers et al., 2009;Hughes et al., 2004;Munafo et al., 2006).”

    From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Hughes et al., 2004

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1 of the 60 references couldn’t be matched to a known paper.

Research works printed but not linked: 7

  1. Charney DS, Delgado PL (1992). Current concepts of serotonin neuronal function and the pathophysiology of depression. In : Elliot M, Heal DJ, Marsden CA (Eds.), Experimental Approaches to Anxiety and Depression. London : Wiley.
  2. Davidson RJ (1994). On emotion, mood, and related affective constructs. In : Ekman P, Davidson RJ (Eds.), The Nature of Emotion : Fundamental Questions. New York : Oxford University Press.
  3. Delgado PL (2000). Depression : the case for a monoamine deficiency. Journal of Clinical Psychiatry 61, 7-11.
  4. Gainotti G (2001). Emotions as a biological adaptive system : an introduction. In : Gainotti G (Ed.), Handbook of Neuropsychology, vol. 5 (2nd edn). Amsterdam : Elsevier Science.
  5. Greco E (1993). The emotional stroop test : a review of the literature. Analytic Psychotherapy and Psychopathology 3, 219-223.
  6. Schatzberg AF, Schildkraut JJ (1995). Recent studies on norepinephrine systems in mood disorders. In : Bloom FE, Kupfer DJ (Eds.), Pharmacology : The Fourth Generation of Progress. New York : Raven Press.
  7. Scherer KR, Peper M (2001). Psychological theories of emotion and neuropsychological research. In : Gainotti G (Ed.), Handbook of Neuropsychology, vol. 5 (2nd edn). Amsterdam : Elesevier Science.

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Authors
Hughes, J.-M., Matrenza, C., Kemp, A. H., Harrison, B. J., Liley, D., & Nathan, P. J.
Affiliations
Swinburne University of Technology (AU)
Corresponding author
Nathan, Pradeep J.
ORCID
Venue
The International Journal of Neuropsychopharmacology
Publisher
Oxford University Press (OUP)
Published
2004-03
Volume
7
Issue
1
Pages
9-17
ISSN
  • 1461-1457 (ISSN-L)
  • 1469-5111
DOI
10.1017/s1461145703003845
OpenAlex
W2078816984
Cited by
16
References
60
Citations by year
2016: 1
FWCI
1.05
Type
journal article
Language
en
Open access
Locations
  • The International Journal of Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
  • Swinburne figshare (Swinburne University of Technology) (submittedVersion)
  • Swinburne figshare (Swinburne University of Technology)
Funders
  • Australian Government
  • Swinburne University of Technology
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
monoamine depletion, tryptophan depletion, mood, emotional responsiveness, serotonin, catecholamines, sad mood, antagonism, Profile of Mood States, emotional Stroop task, International Affective Picture System
MeSH terms
Adolescent, Adult, Affect, Amino Acids, Double-Blind Method, Female, Humans, Phenylalanine, Psychometrics, Reaction Time, Tryptophan, Tyrosine, Biogenic Monoamines, Cross-Over Studies, Expressed Emotion

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