Predicting inter-hemispheric transfer time from the diffusion properties of the corpus callosum in healthy individuals and schizophrenia patients: A combined ERP and DTI study
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Background Several theories of schizophrenia have emphasized the role of aberrant neural timing in the etiology of the disease, possibly as a consequence of conduction delays caused by structural damage to the white-matter fasciculi. Consistent with this theory, increased inter-hemispheric transmission times (IHTTs) to unilaterally-presented visual stimuli have been reported in patients with schizophrenia. The present study investigated whether or not these IHTT abnormalities could be underpinned by structural damage to the visual fibers of the corpus callosum.Methods Thirty three schizophrenia patients and 22 matched controls underwent Event Related Potential (ERP) recording, and a subset of 19 patients and 16 controls also underwent 3T Diffusion-Tensor Imaging (DTI). Unilateral visual stimuli (squares, 2×2 degrees) were presented 6 degrees lateral to either side of a central fixation point. IHTTs (ipsilateral minus contralateral latencies) were calculated for the P1 and N1 components at parietal-occipital sites in current source density-transformed ERPs. The visual fibers of the corpus callosum were extracted with streamline tractography and the diffusion metrics of Fractional Anisotropy (FA) and Mode calculated.Results While both subject groups exhibited highly significant IHTTs across a range of posterior electrode pairs, and significantly shorter IHTTs from left-to-right hemisphere than vice versa, no significant groupwise differences in IHTT were observed. However, participants' IHTTs were linearly related to their FA and Mode, with longer IHTTs being associated with lower FA and more prolate diffusion ellipsoids.Conclusions These results suggest that IHTTs are estimable from DTI measures of white matter integrity. In light of the range of diffusion abnormalities that have been reported in patients with schizophrenia, particularly in frontal fasciculi, these results support the conjecture that schizophrenia is associated with abnormalities in neural timing.
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Higher FA is related to interhemispheric transition time measured with event-related potentials (ERP) and quantitative electroencephalography (EEG).
“Moreover, a higher FA has been related to interhemispheric transition time measured with event-related potentials (ERP) 45 and quantitative electroencephalography (EEG). 46”
From Physical exercise keeps the brain connected: biking increases white matter integrity in patients with schizophrenia and healthy controls. (2015) · cites this paper as [45]
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- Authors
- Whitford, T. J., Kubicki, M., Ghorashi, S., Schneiderman, J. S., Hawley, K. J., McCarley, R. W., Shenton, M. E., & Spencer, K. M.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Corresponding author
- Whitford, Thomas J.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 54
- Issue
- 3
- Pages
- 2318-2329
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3006645
- OpenAlex
- W2088965760
- Cited by
- 83
- References
- 75
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 10 · 2013: 11 · 2012: 5
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Health and Medical Research Council of Australia (NHMRC 520627)
- US Department of Veterans Affairs
- Schizophrenia Center
- National Institutes of Health (R01 MH50747, K05 MH070047, R01 MH080187, P50 MH080272, R01 MH040799, R03 MH068464, T32 MH016259)
- Harvard Medical School
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- schizophrenia, corpus callosum, white matter integrity, fractional anisotropy, event-related potentials, P1 and N1 components, visual evoked potentials, neural timing, conduction delay
- MeSH terms
- Adult, Corpus Callosum, Diffusion, Electroencephalography, Evoked Potentials, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Male, Middle Aged, Nerve Fibers, Neural Conduction, Photic Stimulation, Schizophrenia, Schizophrenic Psychology, Visual Pathways, Anisotropy, Diagnostic and Statistical Manual of Mental Disorders, Young Adult, Diffusion Tensor Imaging
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