Cited by 77Genetic Associations and EpidemiologyAssisted Reproductive Technology and Twin PregnancyCognitive Abilities and Testing

The National Longitudinal Study of Adolescent Health (Add Health) Sibling Pairs Data

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Harris, Kathleen Mullan, Halpern, Carolyn Tucker, Haberstick, Brett C., Smolen, Andrew·2013·Twin Research and Human Genetics

Abstract

This article describes the design and phenotype and genotype data available for sibling pairs with varying genetic relatedness in the National Longitudinal Study of Adolescent Health (Add Health). Add Health is a nationally representative longitudinal study of over 20,000 adolescents in the United States in 1994–1995 who have been followed for 15 years into adulthood. The Add Health design included oversamples of more than 3,000 pairs of individuals with varying genetic resemblance, ranging from monozygotic twins, dizygotic twins, full siblings, half siblings, and unrelated siblings who were raised in the same household. Add Health sibling pairs are therefore nationally representative and followed longitudinally from early adolescence into adulthood with four in-home interviews during the period 1994–2009. Add Health has collected rich longitudinal social, behavioral, environmental, and biological data, as well as buccal cell DNA from all sample members, including sibling pairs. Add Health has an enlightened dissemination policy and to date has released phenotype and genotype data to more than 10,000 researchers in the scientific community.

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  1. Ge X Natsuaki MN Neiderhiser JM Reiss D Genetic and environmental influences on pubertal timing: Results from two national sibling studies Journal of Research on Adolescence 2007 17 767 788
  2. Noble EP Ozkaragoz TZ Ritchie TL Zhang X Belin TR Sparks RS D2 and D4 dopamine receptor polymorphisms and personality American Journal of Medical Genetics 1998 81 257 267 9603615

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Authors
Harris, K. M., Halpern, C. T., Haberstick, B. C., & Smolen, A.
Affiliations
  • University of North Carolina at Chapel Hill (US)
  • University of Colorado Boulder (US)
Corresponding author
Harris, Kathleen Mullan
Venue
Twin Research and Human Genetics
Published
2012-12-12
Volume
16
Issue
1
Pages
391-398
ISSN
  • 1832-4274 (ISSN-L)
  • 1839-2628
OpenAlex
W1993064061
Cited by
77
References
50
Citations by year
2026: 4 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 9 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 2
FWCI
2.46
Type
journal article
Language
en
Open access
Locations
  • Twin Research and Human Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • National Institutes of Health (2r24hd050924-06)
  • Gillings School of Public Health
  • University of North Carolina at Chapel Hill (P01‐HD31921)
  • National Institute on Alcohol Abuse and Alcoholism (AA-07464, T32AA007464)
  • National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24 HD-050924, P01HD031921, R01HD073342)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
Add Health, sibling pairs, genetic relatedness, monozygotic twins, dizygotic twins, full siblings, half-siblings, phenotypic data, genotype data, buccal cell DNA, adolescent development, longitudinal follow-up, data dissemination
MeSH terms
Adolescent, Adult, Diseases in Twins, Female, Genetics, Behavioral, Genotype, Humans, Longitudinal Studies, Male, North Carolina, Phenotype, Registries, Social Environment, Twins, Dizygotic, Twins, Monozygotic, Epidemiologic Research Design, Siblings, Young Adult, Gene-Environment Interaction

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