The National Longitudinal Study of Adolescent Health (Add Health) Sibling Pairs Data
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This article describes the design and phenotype and genotype data available for sibling pairs with varying genetic relatedness in the National Longitudinal Study of Adolescent Health (Add Health). Add Health is a nationally representative longitudinal study of over 20,000 adolescents in the United States in 1994–1995 who have been followed for 15 years into adulthood. The Add Health design included oversamples of more than 3,000 pairs of individuals with varying genetic resemblance, ranging from monozygotic twins, dizygotic twins, full siblings, half siblings, and unrelated siblings who were raised in the same household. Add Health sibling pairs are therefore nationally representative and followed longitudinally from early adolescence into adulthood with four in-home interviews during the period 1994–2009. Add Health has collected rich longitudinal social, behavioral, environmental, and biological data, as well as buccal cell DNA from all sample members, including sibling pairs. Add Health has an enlightened dissemination policy and to date has released phenotype and genotype data to more than 10,000 researchers in the scientific community.
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Despite generational differences, the polygenic score performed similarly in Add Health and Health and Retirement Study samples.
“Despite these generational differences, the polygenic score performed similarly in both samples.”
From Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use (2019) · cites this paper as [20]
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- Authors
- Harris, K. M., Halpern, C. T., Haberstick, B. C., & Smolen, A.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- University of Colorado Boulder (US)
- Corresponding author
- Harris, Kathleen Mullan
- Venue
- Twin Research and Human Genetics
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-12-12
- Volume
- 16
- Issue
- 1
- Pages
- 391-398
- ISSN
- 1832-4274 (ISSN-L)
- 1839-2628
- PMC
- PMC3574787
- OpenAlex
- W1993064061
- Cited by
- 77
- References
- 50
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 9 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 2
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Twin Research and Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (2r24hd050924-06)
- Gillings School of Public Health
- University of North Carolina at Chapel Hill (P01‐HD31921)
- National Institute on Alcohol Abuse and Alcoholism (AA-07464, T32AA007464)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24 HD-050924, P01HD031921, R01HD073342)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- Add Health, sibling pairs, genetic relatedness, monozygotic twins, dizygotic twins, full siblings, half-siblings, phenotypic data, genotype data, buccal cell DNA, adolescent development, longitudinal follow-up, data dissemination
- MeSH terms
- Adolescent, Adult, Diseases in Twins, Female, Genetics, Behavioral, Genotype, Humans, Longitudinal Studies, Male, North Carolina, Phenotype, Registries, Social Environment, Twins, Dizygotic, Twins, Monozygotic, Epidemiologic Research Design, Siblings, Young Adult, Gene-Environment Interaction
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