Cited by 52Suicide and Self-Harm StudiesGenetic Associations and EpidemiologyChild and Adolescent Psychosocial and Emotional Development

Genetic Contribution to Suicidal Behaviors and Associated Risk Factors among Adolescents in the U.S.

Cho, Hyunsan, Guo, Guang, Iritani, Bonita J., Hallfors, Denise Dion·2006·Prevention Science

Abstract

This paper examines genetic contribution to suicidal behaviors and other risk factors associated with suicidal behavior among adolescents in the U.S. Using adolescent twin data in the National Longitudinal Study of Adolescent Health (N = 1448), we compared concordance in suicidal ideation and attempt among monozygotic (MZ) and dizygotic (DZ) twins. Heritability of risk factors for suicidal behaviors also was examined using Pearson correlation and mixed-model analyses. A trend of higher concordance in suicidal ideation and attempt was found among MZ than DZ twins but the difference was not statistically significant by the stringent test of bootstrapping analysis. Evidence of heritability was found for several suicide risk factors. The percentage of variance explained by heritability was larger among female twins for depression, aggression, and quantity of cigarettes smoked in comparison to heritability estimates for male twins. However, estimated heritability was larger among male than female twins for alcohol use and binge drinking. Heritability influence was negligible among both sexes for other drug use. Risk factors for suicidal behaviors among adolescents may be heritable. Gender differences found in the heritability of some suicide risk factors suggest these genetic contributions are gender specific. Future research examining potential interactions between expression of genetic influence and particular environmental contexts may enhance prevention and intervention efforts.

Integrity signals

Registry

Crossref · 10.1007/s11121-006-0042-5

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Omega-3 fatty acid deficiency may reduce membrane fluidity, impair serotonergic signaling, and amplify oxidative stress, thereby heightening suicide vulnerability.

    “These fatty acids possess strong anti-inflammatory and neuroprotective properties, and their deficiency may reduce membrane fluidity, impair serotonergic signaling, and amplify oxidative stress, thereby heightening suicide vulnerability (79).”
  • Studies including adolescent twins do not in most cases report finding any shared environmental influences.

    “Studies including adolescent twins (∼ younger than 19 years of age) do not in most cases report finding any shared environmental influences (Table 8.2; e.g., Button et al., 2004; Cho et al., 2006; Gelhorn et al., 2006; Tackett et al., 2009).”

    From Human Aggression Across the Lifespan (2011) · cites this paper as Cho et al., 2006

Cites

Flagged first, then by citations

3 of the 61 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Cho, H., Guo, G., Iritani, B. J., & Hallfors, D. D.
Affiliations
  • Pacific Institute For Research and Evaluation (US)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
Cho, Hyunsan
Venue
Prevention Science
Published
2006-06-08
Volume
7
Issue
3
Pages
303-311
ISSN
  • 1389-4986 (ISSN-L)
  • 1573-6695
OpenAlex
W2027749059
Cited by
52
References
61
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 16 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 4
FWCI
3.32
Type
journal article
Language
en
Open access
closed
Locations
  • Prevention Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Drug Abuse (R01DA14496, R01DA014496)
  • National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01- HD31921, P01HD031921)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
adolescent suicide, suicidal ideation, suicide attempts, heritability, twin concordance, monozygotic twins, dizygotic twins, suicide risk factors, gender differences, depression, aggression, cigarette smoking, alcohol consumption, binge drinking, drug use, adolescent health
MeSH terms
Suicide Prevention, Adolescent, Adolescent Behavior, Female, Humans, Male, Risk Factors, Twins, Dizygotic, Twins, Monozygotic, United States

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review