Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment
Abstract
There is a robust relationship between the experience of maltreatment in childhood and later antisocial behaviors amongst adolescents and adults. Animal and human studies suggest that variation in monoamine oxidase A (MAOA) genotype may moderate the effects of maltreatment. Self-reported conduct problems and criminal convictions amongst sibling-pairs from the National Longitudinal Study of Adolescent Health were tested for association with reports of maltreatment before and after the age of 12. MAOA promoter polymorphisms were tested for possible moderation effects. Maltreatment predicted conduct problems and criminal convictions. MAOA genotype did not have a significant moderating effect in any of the six analyses that were conducted. We did not replicate a previous report that MAOA polymorphisms moderated the relationship between maltreatment and conduct problems. There was, however, a non-significant trend in the predicted direction. Additional studies will be needed before firm conclusions can be drawn about this hypothesized genotype-environment interaction.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A meta-analysis of five studies found that the association between maltreatment and mental health problems was significantly stronger in males with low versus high MAO-A activity.
“The association between maltreatment and mental health problems was significantly stronger in the group of males with a genotype conferring low versus high MAO-A activity.”
From Human Aggression Across the Lifespan (2011) · cites this paper as Haberstick et al., 2005
There is at least one published failure to replicate the MAO-A finding, and the finding has not been replicated in females or in African Americans.
“However, there is at least one published failure to replicate (Haberstick et al., 2005), and this finding has been replicated neither in females (Sjöberg et al., 2007) nor in African Americans (Widom and Brzustowicz, 2006).”
From Human Aggression Across the Lifespan (2011) · cites this paper as Haberstick et al., 2005
Cites
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842 · see citing works
Protecting Adolescents From Harm: Findings From the National Longitudinal Study on Adolescent Health
Resnick, M. D. (1997) · JAMA · doi:10.1001/jama.1997.03550100049038 · Cited by 2,846 · see citing works
Impact of sexual abuse on children: A review and synthesis of recent empirical studies
Kendall-Tackett, K. A., Williams, L. M., & Finkelhor, D. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.113.1.164 · Cited by 2,537 · see citing works
Edwards, V. J., Holden, G. W., Felitti, V. J., & Anda, R. F. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1453 · Cited by 1,832 · see citing works
Mechanisms in the Cycle of Violence
Dodge, K. A., Bates, J. E., & Pettit, G. S. (1990) · Science · doi:10.1126/science.2270481 · Cited by 1,803 · see citing works
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
Brunner, H. G., Nelen, M., Breakefield, X. O., Ropers, H. H., & van Oost, B. A. (1993) · Science · doi:10.1126/science.8211186 · Cited by 1,644 · see citing works
The neurobiological consequences of early stress and childhood maltreatment
Teicher, M. H., Andersen, S. L., Polcari, A., Anderson, C. M., Navalta, C. P., & Kim, D. M. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00007-1 · Cited by 1,465 · see citing works
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225 · see citing works
MONOAMINE OXIDASE: From Genes to Behavior
Shih, J. C., Chen, K., & Ridd, M. J. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.197 · Cited by 1,211 · see citing works
A functional polymorphism in the monoamine oxidase A gene promoter
Sabol, S. Z., Hu, S., & Hamer, D. (1998) · Human Genetics · doi:10.1007/s004390050816 · Cited by 1,079 · see citing works
The long-term impact of the physical, emotional, and sexual abuse of children: A community study
Mullen, P. E., Martin, J. L., Anderson, J. C., Romans, S. E., & Herbison, P. (1996) · Child Abuse & Neglect · doi:10.1016/0145-2134(95)00112-3 · Cited by 1,026 · see citing works
SÁNCHEZ, M. M., LADD, C. O., & PLOTSKY, P. M. (2001) · Development and Psychopathology · doi:10.1017/s0954579401003029 · Cited by 1,003 · see citing works
BROWN, J., COHEN, P., JOHNSON, J. G., & SMAILES, E. M. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199912000-00009 · Cited by 842 · see citing works
Childhood Maltreatment Increases Risk for Personality Disorders During Early Adulthood
Johnson, J. G., Cohen, P., Brown, J., Smailes, E. M., & Bernstein, D. P. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.7.600 · Cited by 839 · see citing works
Lansford, J. E., Dodge, K. A., Pettit, G. S., Bates, J. E., Crozier, J., & Kaplow, J. (2002) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.156.8.824 · Cited by 838 · see citing works
Child abuse and neglect and the brain–a review
Glaser, D. (2000) · Journal of Child Psychology and Psychiatry · doi:10.1017/s0021963099004990 · Cited by 827 · see citing works
DE BELLIS, M. D. (2001) · Development and Psychopathology · doi:10.1017/s0954579401003078 · Cited by 816 · see citing works
Long-term consequences of childhood physical abuse.
Malinosky-Rummell, R., & Hansen, D. J. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.114.1.68 · Cited by 731 · see citing works
THORNBERRY, T. P., IRELAND, T. O., & SMITH, C. A. (2001) · Development and Psychopathology · doi:10.1017/s0954579401004114 · Cited by 579 · see citing works
The role of self-organization in the promotion of resilience in maltreated children
Cicchetti, D., & Rogosch, F. A. (1997) · Development and Psychopathology · doi:10.1017/s0954579497001442 · Cited by 519 · see citing works
Psychosocial sequelae of violent victimization in a national youth sample.
Boney‐McCoy, S., & Finkelhor, D. (1995) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.63.5.726 · Cited by 460 · see citing works
Maltreatment, competency deficits, and risk for academic and behavioral maladjustment.
Shonk, S. M., & Cicchetti, D. (2001) · Developmental Psychology · doi:10.1037/0012-1649.37.1.3 · Cited by 391 · see citing works
Physical punishment/maltreatment during childhood and adjustment in young adulthood
Fergusson, D. M., & Lynskey, M. T. (1997) · Child Abuse & Neglect · doi:10.1016/s0145-2134(97)00021-5 · Cited by 385 · see citing works
KEILEY, M. K., HOWE, T. R., DODGE, K. A., BATES, J. E., & PETTIT, G. S. (2001) · Development and Psychopathology · doi:10.1017/s0954579401004084 · Cited by 323 · see citing works
Alcohol abuse in abused and neglected children followed-up: are they at increased risk?
Widom, C. S., Ireland, T., & Glynn, P. J. (1995) · Journal of Studies on Alcohol · doi:10.15288/jsa.1995.56.207 · Cited by 235 · see citing works
Adolescent Physical Abuse: Risk for Adolescent Psychiatric Disorders
Kaplan, S. J., Pelcovitz, D., Salzinger, S., Weiner, M., Mandel, F. S., LESSER, M. L., & Labruna, V. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.7.954 · Cited by 222 · see citing works
Denney, R. M., Koch, H., & Craig, I. (1999) · Human Genetics · doi:10.1007/s004399900183 · Cited by 201 · see citing works
Jacobson, K. C., & Rowe, D. (1999) · Developmental Psychology · doi:10.1037/0012-1649.35.4.926 · Cited by 187 · see citing works
Why is sexual abuse declining? a survey of state child protection administrators
Jones, L. M., Finkelhor, D., & Kopiec, K. (2001) · Child Abuse & Neglect · doi:10.1016/s0145-2134(01)00263-0 · Cited by 143 · see citing works
The Treatment of the Long-term Sequelae of Child Abuse
Stevenson, J. (1999) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00425 · Cited by 127 · see citing works
Mejia, J. M., Ervin, F. R., Baker, G. B., & Palmour, R. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01418-x · Cited by 70 · see citing works
Structure of the human gene for monoamine oxidase type A
Chen, Z., Hotamışlıgil, G. S., Huang, J., Wen, L., Ezzeddine, D., Aydin-Muderrisoglu, N., Powell, J. F., Huang, R. H., Breakefield, X. O., Craig, I., et al. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.16.4537 · Cited by 65 · see citing works
Fagan, A. A. (2003) · Violence and Victims · doi:10.1891/vivi.2003.18.4.445 · Cited by 54 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Burden and consequences of child maltreatment in high-income countries
Gilbert, R., Widom, C. S., Browne, K., Fergusson, D., Webb, E., & Janson, S. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61706-7 · Cited by 3,876 · see citing works
Gene–environment interactions in psychiatry: joining forces with neuroscience
Caspi, A., & Moffitt, T. E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1925 · Cited by 1,300 · see citing works
Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., & Moffitt, T. E. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001851 · Cited by 1,158 · see citing works
Gene-environment interplay and psychopathology: multiple varieties but real effects
Rutter, M., Moffitt, T. E., & Caspi, A. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01557.x · Cited by 1,058 · see citing works
The role of early life stress as a predictor for alcohol and drug dependence
Enoch, M.-A. (2011) · Psychopharmacology · doi:10.1007/s00213-010-1916-6 · Cited by 668 · see citing works
Reif, A., Rösler, M., Freitag, C. M., Schneider, M., Eujen, A., Kissling, C., Wenzler, D., Jacob, C. P., Retz-Junginger, P., Thome, J., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301359 · Cited by 277 · see citing works
Meta-analysis of gene–environment interactions in developmental psychopathology
Taylor, A., & Kim-Cohen, J. (2007) · Development and Psychopathology · doi:10.1017/s095457940700051x · Cited by 227 · see citing works
Weder, N., Yang, B. Z., Douglas-Palumberi, H., Massey, J., Krystal, J. H., Gelernter, J., & Kaufman, J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.013 · Cited by 190 · see citing works
Serotonergic genes and suicide: A systematic review
Antypa, N., Serretti, A., & Rujescu, D. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.03.013 · Cited by 150 · see citing works
Genetics of aggressive behavior: An overview
Veroude, K., Zhang‐James, Y., Fernàndez‐Castillo, N., Bakker, M. J., Cormand, B., & Faraone, S. V. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32364 · Cited by 147 · see citing works
Adolescent girls and criminal activity: Role of MAOA-LPR genotype and psychosocial factors
Sjöberg, R. L., Nilsson, K. W., Wargelius, H., Leppert, J., Lindström, L., & Oreland, L. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30360 · Cited by 143 · see citing works
Stress, Genes and the Biology of Suicidal Behavior
Currier, D., & Mann, J. J. (2008) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2008.01.005 · Cited by 142 · see citing works
Weeland, J., Overbeek, G., de Castro, B. O., & Matthys, W. (2015) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-015-0196-4 · Cited by 138 · see citing works
Human Aggression Across the Lifespan
Tuvblad, C., & Baker, L. A. (2011) · Advances in Genetics · doi:10.1016/b978-0-12-380858-5.00007-1 · Cited by 139 · see citing works
“However, there is at least one published failure to replicate (Haberstick et al., 2005), and this finding has been replicated neither in females (Sjöberg et al.”
BackgroundMethodResultBeaver, K. M., Wright, J., DeLisi, M., Walsh, A., Vaughn, M. G., Boisvert, D., & Vaske, J. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-30 · Cited by 131 · see citing works
Aggressive behavior in humans: Genes and pathways identified through association studies
Fernàndez‐Castillo, N., & Cormand, B. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32419 · Cited by 87 · see citing works
The National Longitudinal Study of Adolescent Health (Add Health) Sibling Pairs Data
Harris, K. M., Halpern, C. T., Haberstick, B. C., & Smolen, A. (2013) · Twin Research and Human Genetics · doi:10.1017/thg.2012.137 · Cited by 77 · see citing works
Self-citationThe etiology of criminal onset: The enduring salience of nature and nurture
DeLisi, M., Beaver, K. M., Wright, J. P., & Vaughn, M. G. (2008) · Journal of Criminal Justice · doi:10.1016/j.jcrimjus.2008.04.001 · Cited by 64 · see citing works
Malik, A. I., Zai, C. C., Berall, L., Abu, Z., Din, F., Nowrouzi, B., Chen, S., & Beitchman, J. H. (2014) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000044 · Cited by 29 · see citing works
Gene–Environment Interactions in the Etiology of Human Violence
Laucht, M., Brandeis, D., & Zohsel, K. (2013) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2013_260 · Cited by 18 · see citing works
- Authors
- Haberstick, B. C., Lessem, J. M., Hopfer, C. J., Smolen, A., Ehringer, M. A., Timberlake, D., & Hewitt, J. K.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Haberstick, Brett C.
- ORCID
- Venue
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2005-04
- Volume
- 135B
- Issue
- 1
- Pages
- 59-64
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W1999565392
- Cited by
- 277
- References
- 33
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 4 · 2021: 13 · 2020: 4 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 11 · 2015: 13 · 2014: 17 · 2013: 23 · 2012: 18
- FWCI
- 27.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (R01 DA 15522-01, R01DA015522)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD031921, HD 07289, T32HD007289)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- monoamine oxidase A, child abuse, adolescent maltreatment, antisocial behavior, conduct problems, criminal conviction, gene-environment interaction, moderating effect, Add Health
- MeSH terms
- Adolescent, Adolescent Behavior, Adult, Antisocial Personality Disorder, Child, Child Abuse, Child Behavior, Female, Genotype, Humans, Male, Monoamine Oxidase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
