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Cited by 564Child and Adolescent Psychosocial and Emotional DevelopmentPsychopathy, Forensic Psychiatry, Sexual OffendingNeurotransmitter Receptor Influence on Behavior

Childhood Adversity, Monoamine Oxidase A Genotype, and Risk for ConductDisorder

Foley, Debra L., Eaves, Lindon J., Wormley, Brandon, Silberg, Judy L., Maes, Hermine H., Kuhn, Jonathan, Riley, Brien·2004·Archives of General Psychiatry
DOI 10.1001/archpsyc.61.7.738
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Abstract

BACKGROUND: Very little is known about how different sets of risk factors interact to influence risk for psychiatric disorder. OBJECTIVE: To replicate a recent report of a genotype-environment interaction that predicts risk for antisocial behavior in boys. DESIGN: Characterizing risk for conduct disorder in boys in association with monoamine oxidase A genotype and exposure to familial adversity, defined by interparental violence, parental neglect, and inconsistent discipline. SETTING: A community-based sample of twin boys. PARTICIPANTS: Five hundred fourteen male twins aged 8 to 17 years. MAIN OUTCOME MEASURE: Conduct disorder. RESULTS: There was a main effect of adversity but not of monoamine oxidase A on risk for conduct disorder. Low monoamine oxidase A activity increased risk for conduct disorder only in the presence of an adverse childhood environment. Neither a passive nor an evocative genotype-environment correlation accounted for the interaction. CONCLUSION: This study replicates a recent report of a genotype-environment interaction that predicts individual variation in risk for antisocial behavior in boys.

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  • A functional polymorphism in the MAOA gene moderates the effects of a risk environment on the development of antisocial behavior.

    “A functional polymorphism in the monoamine oxidase A (MAOA) gene has been found to moderate the effects of a risk environment on the development of antisocial behavior (Caspi et al., 2002;Foley et al., 2004).”

    From Heritability for adolescent antisocial behavior differs with socioeconomic status: gene–environment interaction (2006) · cites this paper as Foley et al., 2004

  • Further research has replicated and extended the finding that parent neglect as well as abuse in conjunction with the polymorphism increases risk for conduct problems and violence.

    “Further research has replicated and extended the finding by noting that parent neglect as well as abuse in conjunction with the polymorphism increase risk for conduct problems and violence (Foley et al. 2004, Jaffee et al. 2005).”

    From Mediators and Mechanisms of Change in Psychotherapy Research (2007) · cites this paper as Foley et al. 2004

  • A meta-analysis of five studies found that the association between maltreatment and mental health problems was significantly stronger in males with low versus high MAO-A activity.

    “The association between maltreatment and mental health problems was significantly stronger in the group of males with a genotype conferring low versus high MAO-A activity.”

    From Human Aggression Across the Lifespan (2011) · cites this paper as Foley et al., 2004

  • Only a few replications of the MAO-A finding have been published.

    “So far, there have only been a few replications of this important finding (Foley et al., 2004; Kim-Cohen et al., 2006; Nilsson et al., 2006).”

    From Human Aggression Across the Lifespan (2011) · cites this paper as Foley et al., 2004

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Authors
Foley, D. L., Eaves, L. J., Wormley, B., Silberg, J. L., Maes, H. H., Kuhn, J., & Riley, B.
Affiliations
Virginia Commonwealth University (US)
ORCID
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
2004-07-01
Volume
61
Issue
7
Pages
738
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.61.7.738
OpenAlex
W2147817341
Cited by
564
References
33
Citations by year
2026: 4 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 12 · 2019: 6 · 2018: 15 · 2017: 13 · 2016: 26 · 2015: 26 · 2014: 33 · 2013: 33 · 2012: 32
FWCI
69.99
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH57761, MH45268, R01MH045268, P30MH057761)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
conduct disorder, monoamine oxidase A, childhood adversity, gene-environment interaction, antisocial behavior, interparental violence, parental neglect, inconsistent discipline, risk factors
MeSH terms
Adolescent, Antisocial Personality Disorder, Child, Child Abuse, Diseases in Twins, Genotype, Humans, Life Change Events, Male, Monoamine Oxidase, Risk Factors, Sex Factors, Social Environment, Virginia, Child of Impaired Parents, Domestic Violence, Conduct Disorder, Genetic Predisposition to Disease

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