In vivo calibration of microdialysis probes for exogenous compounds

Menacherry, Stanley.; Hubert, Walt.; Justice, Joseph B.

doi:10.1021/ac00030a003

Cited by 217Electrochemical Analysis and ApplicationsForensic Toxicology and Drug AnalysisElectrochemical sensors and biosensors

In vivo calibration of microdialysis probes for exogenous compounds

Menacherry, Stanley., Hubert, Walt., Justice, Joseph B.·1992·Analytical Chemistry

DOI 10.1021/ac00030a003

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Abstract

Several approaches for calibrating microdialysis probes for exogenous compounds in vivo are described which avoid the error introduced by in vitro calibration. These methods are based on establishing a steady state of the exogenous compound by a continuous (zero-order) iv infusion. The steady-state concentration is estimated by three methods that directly determine the in vivo concentration. The methods are (a) extrapolation of dialysate concentrations at various flow rates to the concentration at zero flow, (b) dialysis with concentrations of analyte added to the perfusion medium above and below the expected concentration to determine the concentration at no net flux across the membrane, and (c) dialysis at a very slow perfusion rate (57 nL/min) where the recovery is expected to be better than 90%. Using these approaches, the recovery for cocaine in the brain was found to be (8.9 +/- 0.68)%, as compared to an in vitro recovery of (5.1 +/- 0.18)% at 24 degrees C and (7.4 +/- 0.18)% at 37 degrees C, at a perfusion rate of 1.2 microL/min through a 0.3- X 2-mm microdialysis probe. The in vivo concentration of cocaine in the rat brain for an intravenous dose of 0.3 mg/kg per min was found to be 17.1 +/- 1.3 microM.

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The maximum in vivo steady state concentration of an analyte being dialyzed exists at the point at which there is no flow of the perfusion buffer.
“Theoretically, the maximum in vivo steady state concentration of an analyte being dialyzed exists at the point at which there is no flow of the perfusion buffer (31, 33).”
From Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance (2011) · cites this paper as [33]
The actual in vivo steady state concentration of an analyte being dialyzed exists at the point at which there is no flow of the perfusion buffer.
“Theoretically, the actual in vivo steady state concentration of an analyte being dialyzed exists at the point at which there is no flow of the perfusion buffer (Menacherry et al., 1992).”
From Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance (2009) · cites this paper as Menacherry et al., 1992

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Authors: Menacherry, S., Hubert, W., & Justice, J. B.
Affiliations: Emory University (US)
Venue: Analytical Chemistry
Publisher: American Chemical Society (ACS)
Published: 1992-03-15
Volume: 64
Issue: 6
Pages: 577-583
ISSN: 0003-2700 (ISSN-L)
1520-6882
DOI: 10.1021/ac00030a003
OpenAlex: W2023584567
Cited by: 217
References: 24
Citations by year: 2025: 5 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 9
FWCI: 14.93
Type: journal article
Language: en
Open access: closed
Locations: Analytical Chemistry (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
National Institute on Drug Abuse (DA-05827)
Topics: Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
Keywords: in vivo calibration, exogenous compounds, steady-state concentration, intravenous infusion, dialysate flow rate, permeate flux, analyte recovery, cocaine, rat brain
MeSH terms: Animals, Brain, Calibration, Cocaine, Dialysis, Female, Infusions, Intravenous, Rats, Inbred Strains, Rats, In Vitro Techniques

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In vivo calibration of microdialysis probes for exogenous compounds

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