Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of β-Amyloid in Mice with Alzheimer’s Disease Pathology
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Decreased sleep and attenuation of circadian fluctuations in Aβ reflect amyloid-associated pathology in Alzheimer’s disease.
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SD is associated with fluctuations in CSF Aβ, as well as Aβ deposition in the brain.
“SD is associated with fluctuations in CSF Aβ, as well as Aβ deposition in the brain [567].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [567]
After Aβ plaque formation, the sleep-wake cycle is impaired and diurnal fluctuation in ISF/CSF Aβ levels is lost.
“However, after Aβ plaque formation, there is an impaired sleep-wake cycle and loss of diurnal fluctuation in ISF/CSF Aβ levels (Roh et al., 2012).”
From Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019) · cites this paper as Roh et al., 2012
In Aβ-overexpressing mice, sleep-wake cycle and diurnal Aβ fluctuations are normal before plaque formation.
“In mice overexpressing Aβ, sleep-wake cycle and diurnal fluctuations in ISF and CSF Aβ levels are normal before an age when animals develop amyloid plaque formation.”
From Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019) · cites this paper as Roh et al., 2012
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Amyloid Burden in Obstructive Sleep Apnea
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- Authors
- Roh, J. H., Huang, Y., Bero, A. W., Kasten, T., Stewart, F. R., Bateman, R. J., & Holtzman, D. M.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Holtzman, David M.
- Venue
- Science Translational Medicine
- Published
- 2012-09-05
- Volume
- 4
- Issue
- 150
- Pages
- 150ra122-150ra122
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3654377
- OpenAlex
- W2109053359
- Cited by
- 563
- References
- 51
- Citations by year
- 2026: 25 · 2025: 32 · 2024: 42 · 2023: 44 · 2022: 47 · 2021: 50 · 2020: 56 · 2019: 51 · 2018: 48 · 2017: 54 · 2016: 39 · 2015: 28 · 2014: 24 · 2013: 17 · 2012: 5
- FWCI
- 15.87
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG013956, K23AG03094604, P01AG026276-S1, P50AG005681, R37AG013956, AG13956, K23AG030946, P01AG026276)
- National Institute of Neurological Disorders and Stroke (P30NS057105, R01NS065667, P01NS074969)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, amyloid-beta, sleep-wake cycle, daily fluctuations, interstitial fluid, cerebrospinal fluid, APPswe/PS1ΔE9 mice, amyloid plaques, presenilin mutations, active immunization, sleep quality, aging
- MeSH terms
- Alzheimer Disease, Animals, Circadian Rhythm, Disease Models, Animal, Genes, Dominant, Hippocampus, Humans, Immunization, Lactates, Mice, Transgenic, Mutation, Sleep, Time Factors, Wakefulness, Amyloid beta-Peptides, Neostriatum, Extracellular Fluid, Mice, Presenilins
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