FIXED‐INTERVAL SCHEDULE OF COCAINE REINFORCEMENT: EFFECT OF DOSE AND INFUSION DURATION1
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Rhesus monkeys were trained on a fixed‐interval 9‐min limited‐hold 3‐min schedule of intravenous cocaine reinforcement. A 15‐min timeout followed each reinforcement or limited‐hold expiration. An identical schedule of food reinforcement was interspersed in the session to assess rate‐modifying effects of the drug infusions not specific to drug reinforcement. In one experiment, response rate for cocaine reinforcement was shown to be a positive function of reinforcement magnitude for a dose range from 0 to 800 ug/kg/inj. At these doses, there was little effect on food reinforced responding except at the highest dose, where responding decreased. Results of the second experiment indicated that increasing the duration of the cocaine infusion produced a change in response rate similar to decreasing unit dose. The response rate change for a given increase in infusion duration was less at a unit dose of 400 ug/kg than at 200 ug/kg.
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Preclinical studies show a correlation between a drug's pharmacokinetic profile and its reinforcing properties.
“This is consistent with preclinical studies showing a similar correlation between a drug's pharmacokinetic profile and its reinforcing properties (Balster and Schuster 1973).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Balster and Schuster 1973
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- Authors
- Balster, R. L., & Schuster, C. R.
- Affiliations
- Duke University (US)
- University of Chicago (US)
- Corresponding author
- Schuster, Charles R.
- Venue
- Journal of the Experimental Analysis of Behavior
- Publisher
- Wiley
- Published
- 1973-07
- Volume
- 20
- Issue
- 1
- Pages
- 119-129
- ISSN
- 0022-5002 (ISSN-L)
- 1938-3711
- PMC
- PMC1334109
- OpenAlex
- W2085038977
- Cited by
- 290
- References
- 19
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 4 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 7 · 2012: 5
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the Experimental Analysis of Behavior (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Chicago
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- cocaine, fixed-interval schedules, dose-response relationship, infusion duration, response rate, food reinforcement, rhesus monkeys
- MeSH terms
- Animals, Haplorhini, Cocaine, Conditioning, Operant, Food, Injections, Intravenous, Macaca, Male, Reaction Time, Reinforcement Schedule
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