Electrochemically Mediated Electrodeposition/Electropolymerization To Yield a Glucose Microbiosensor with Improved Characteristics
Abstract
A procedure is described that provides for electrochemically mediated deposition of enzyme and a polymer layer permselective for endogenous electroactive species. Electrodeposition was first employed for the direct immobilization of glucose oxidase to produce a uniform, thin, and compact film on a Pt electrode. Electropolymerization of phenol was then employed to form an anti-interference and protective polyphenol film within the enzyme layer. In addition, a stability-reinforcing membrane derived from (3-aminopropyl)trimethoxysilane was constructed by electrochemically assisted cross-linking. This hybrid film outside the enzyme layer contributed to the improved stability and permselectivity. The resulting glucose sensor was characterized by a short response time (<4 s), high sensitivity (1200 nA/mM x cm2), low interference from endogenous electroactive species, and working lifetime of more than 50 days.
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Polyphenol permselective membranes can be electropolymerized within an enzyme layer controllably, yielding a self-limiting thickness of 10-100 nm.
“Polyphenol permselective membranes are able to electropolymerize within an enzyme layer in a controllable manner, yielding a film with a thickness that is self-limiting (10–100 nm).”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [60]
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Self-citation
- Authors
- Chen, X., Matsumoto, N., Hu, Y., & Wilson, G. S.
- Affiliations
- University of Kansas (US)
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-01-01
- Volume
- 74
- Issue
- 2
- Pages
- 368-372
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2046064522
- Cited by
- 120
- References
- 29
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 5 · 2013: 9 · 2012: 13
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk055297-03)
- Centers for Disease Control and Prevention (CCR017796)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK55297)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme Catalysis and Immobilization
- Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
- Keywords
- glucose biosensor, glucose oxidase immobilization, electrodeposition, electropolymerization, phenol polymerization, 3-aminopropyltrimethoxysilane, silane crosslinking, permselectivity, platinum electrode, enzyme stability
- MeSH terms
- Electrochemistry, Electrodes, Enzymes, Immobilized, Glucose, Glucose Oxidase, Miniaturization, Polymers, Biosensing Techniques
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