Cited by 661Electrochemical sensors and biosensorsAnalytical Chemistry and SensorsElectrochemical Analysis and Applications

Biosensors for real-time in vivo measurements

Wilson, George S., Gifford, Raeann·2005·Biosensors and Bioelectronics

Abstract

The current status of sensors capable of continuous measurement of analytes in biological media is reviewed. This review containing 173 references deals with devices whose use in single cells, tissue slices, animal models and humans has been demonstrated. In addition to sensors specific for glucose, lactate, glutamate, pyruvate, choline and acetylcholine, insights obtained from monitoring nitric oxide, Na(+), K(+), Ca(2+), and dopamine are presented. Performance criteria for sensor performance are described as is the subject of biosensor calibration. Biocompatibility issues are dealt with in some detail as is the status of continuous blood glucose monitoring in humans.

Integrity signals

Registry

Crossref · 10.1016/j.bios.2004.12.003

Cites

170 of 170 references verified0 citation errors · 0 not checkable

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  • Electron mediators can reduce the impact of interfering species by lowering the working potential needed to oxidize hydrogen peroxide.

    “As described earlier, the use of mediators to shuttle electrons between the enzyme and the electrode can also minimize the impact of interfering species by lowering the working potential required to oxidize hydrogen peroxide.56,58,62”

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Authors
Wilson, G. S., & Gifford, R.
Affiliations
University of Kansas (US)
Corresponding author
Wilson, George S.
Venue
Biosensors and Bioelectronics
Publisher
Elsevier BV
Published
2005-06
Volume
20
Issue
12
Pages
2388-2403
ISSN
0956-5663 (ISSN-L)
OpenAlex
W2090868198
Cited by
660
References
174
Citations by year
2026: 17 · 2025: 21 · 2024: 14 · 2023: 16 · 2022: 17 · 2021: 13 · 2020: 23 · 2019: 27 · 2018: 36 · 2017: 25 · 2016: 37 · 2015: 39 · 2014: 40 · 2013: 50 · 2012: 52
FWCI
2.85
Type
journal article
Language
en
Open access
closed
Locations
  • Biosensors and Bioelectronics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
  • Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
Keywords
biosensors, in vivo monitoring, glucose sensor, lactate sensor, glutamate sensor, nitric oxide sensor, ion sensors, dopamine sensor, sensor calibration, biocompatibility, continuous glucose monitoring
MeSH terms
Blood Glucose, Equipment Design, Transducers, Blood Glucose Self-Monitoring, Biosensing Techniques, Monitoring, Ambulatory, Cell Culture Techniques, Prostheses and Implants

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