Design and in vitro studies of a needle-type glucose sensor for subcutaneous monitoring
Open accessAbstract
A new miniaturized glucose oxidase based needle-type glucose microsensor has been developed for subcutaneous glucose monitoring. The sensor is equivalent in shape and size to a 26-guage needle (0.45-mm o.d.) and can be implanted with ease without any incision. The novel configuration greatly facilitates the deposition of enzyme and polymer films so that sensors with characteristics suitable for in vivo use (upper limit of linear range greater than 15 mM, response time less than 5 min, and sensitivity yielding a 5:1 signal-to-background ratio at normal basal glucose levels) can be prepared in high yield (greater than 60%). The sensor response is largely independent of oxygen tension in the normal physiological range. It also exhibits good selectivity against common interferences except for the exogenous drug acetaminophen.
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Tecoflex SG-85A polyurethane membranes on needle-type glucose sensors in rats after 30 h provided the biocompatibility often seen with polyurethane and ensured ideal sensor performance by limiting glucose diffusion.
“The Tecoflex SG-85A membrane provided the biocompatibility often observed with polyurethane while also ensuring ideal sensor performance by limiting glucose diffusion.34”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [34]
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- Authors
- Bindra, D. S., Zhang, Y., Wilson, G. S., Sternberg, R., Thevenot, D. R., Moatti, D., & Reach, G.
- Affiliations
- University of Kansas (US)
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1991-09-01
- Volume
- 63
- Issue
- 17
- Pages
- 1692-1696
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2009880265
- Cited by
- 309
- References
- 20
- Citations by year
- 2025: 1 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 9 · 2016: 12 · 2015: 9 · 2014: 3 · 2013: 11 · 2012: 10
- FWCI
- 22.25
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- other-oa
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- National Institutes of Health (5r01dk030718-12)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-30718)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme Catalysis and Immobilization
- Keywords
- glucose oxidase, implantable sensors, polymer films, acetaminophen interference, sensor selectivity, sensor miniaturization
- MeSH terms
- Animals, Cattle, Glucose, Glucose Oxidase, Biosensing Techniques, In Vitro Techniques
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