The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Tissue Molecular Ion Imaging by Gold Cluster Ion Bombardment
Abstract
The use of gold cluster focused ion beams produced by a liquid metal ion gun in a TOF-SIMS mass spectrometer is shown to dramatically enhance secondary ion emission of phospholipids and peptides. The method has been successfully tested with cells grown onto plastic slips and with mouse brain slices, without any treatment of the samples. Very reliable time-of-flight mass spectra are acquired with a low primary ion dose of a few 10(7) ions, and high lateral resolution molecular ion images are obtained for heavy ions of great biological interest. This approach offers new opportunities in pharmacological and biological research fields by localizing compounds of interest such as drugs or metabolites in tissues.
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Citations
Cites
Molecular Imaging of Biological Samples: Localization of Peptides and Proteins Using MALDI-TOF MS
Caprioli, R. M., Farmer, T. B., & Gile, J. (1997) · Analytical Chemistry · doi:10.1021/ac970888i · Cited by 2,234
Cited by
Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization
Takáts, Z., Wiseman, J. M., Gologan, B., & Cooks, R. G. (2004) · Science · doi:10.1126/science.1104404 · Cited by 3,324
McDonnell, L. A., & Heeren, R. M. A. (2007) · Mass Spectrometry Reviews · doi:10.1002/mas.20124 · Cited by 1,082
Cluster secondary ion mass spectrometry of polymers and related materials
Mahoney, C. M. (2010) · Mass Spectrometry Reviews · doi:10.1002/mas.20233 · Cited by 293
Bioimaging of metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
Becker, J. S., Zoriy, M., Matusch, A., Wu, B., Salber, D., Palm, C., & Becker, J. S. (2010) · Mass Spectrometry Reviews · doi:10.1002/mas.20239 · Cited by 287
Metadata
- Authors
- Touboul, D., Halgand, F., Brunelle, A., Kersting, R., Tallarek, E., Hagenhoff, B., & Laprévote, O.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-02-17
- Volume
- 76
- Issue
- 6
- Pages
- 1550-1559
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2088212151
- Cited by
- 289
- References
- 1
- FWCI
- 33.14
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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