The DOI matches its Crossref record.
IMS−IMS and IMS−IMS−IMS/MS for Separating Peptide and Protein Fragment Ions
Abstract
Multidimensional ion mobility spectrometry (IMS-IMS and IMS-IMS-IMS) techniques have been combined with mass spectrometry (MS) and investigated as a means of generating and separating peptide and protein fragment ions. When fragments are generated inside a drift tube and then dispersed by IMS prior to MS analysis, it is possible to observe many features that are not apparent from MS analysis alone. The approach is demonstrated by examining fragmentation patterns arising from electrospray ion distributions of insulin chain B and ubiquitin. The multidimensional IMS approach makes it possible to select individual components for collisional activation and to disperse fragments based on differences in mobility prior to MS analysis. Such an approach makes it possible to observe many features not apparent by MS analysis alone.
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Cited by
Ion mobility–mass spectrometry
Kanu, A. B., Dwivedi, P., Tam, M., Matz, L., & Hill, H. H. (2008) · Journal of Mass Spectrometry · doi:10.1002/jms.1383 · Cited by 1,154
Ion mobility mass spectrometry of proteins and proteinassemblies
Uetrecht, C., Rose, R. J., van Duijn, E., Lorenzen, K., & Heck, A. J. R. (2010) · Chem. Soc. Rev. · doi:10.1039/b914002f · Cited by 462
Review on ion mobility spectrometry. Part 1: current instrumentation
Cumeras, R., Figueras, E., Davis, C. E., Baumbach, J. I., & Gràcia, I. (2015) · The Analyst · doi:10.1039/c4an01100g · Cited by 459
Protein Complexes in the Gas Phase: Technology for Structural Genomics and Proteomics
Benesch, J. L. P., Ruotolo, B. T., Simmons, D. A., & Robinson, C. V. (2007) · Chemical Reviews · doi:10.1021/cr068289b · Cited by 408
Zhang, Z., Wu, S., Stenoien, D. L., & Paša-Tolić, L. (2014) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-071213-020216 · Cited by 323
Collision induced unfolding of isolated proteins in the gas phase: past, present, and future
Dixit, S. M., Polasky, D. A., & Ruotolo, B. T. (2018) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2017.11.010 · Cited by 235
Ion mobility in the pharmaceutical industry: an established biophysical technique or still niche?
Campuzano, I. D., & Lippens, J. L. (2018) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2017.11.008 · Cited by 42
Metadata
- Authors
- Merenbloom, S. I., Koeniger, S. L., Valentine, S. J., Plasencia, M. D., & Clemmer, D. E.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-03-08
- Volume
- 78
- Issue
- 8
- Pages
- 2802-2809
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2054319403
- Cited by
- 200
- References
- 0
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- closed
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