The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Quantitative Vibrational Imaging by Hyperspectral Stimulated Raman Scattering Microscopy and Multivariate Curve Resolution Analysis
Open accessAbstract
Spectroscopic imaging has been an increasingly critical approach for unveiling specific molecules in biological environments. Toward this goal, we demonstrate hyperspectral stimulated Raman loss (SRL) imaging by intrapulse spectral scanning through a femtosecond pulse shaper. The hyperspectral stack of SRL images is further analyzed by a multivariate curve resolution (MCR) method to reconstruct quantitative concentration images for each individual component and retrieve the corresponding vibrational Raman spectra. Using these methods, we demonstrate quantitative mapping of dimethyl sulfoxide concentration in aqueous solutions and in fat tissue. Moreover, MCR is performed on SRL images of breast cancer cells to generate maps of principal chemical components along with their respective vibrational spectra. These results show the great capability and potential of hyperspectral SRL microscopy for quantitative imaging of complicated biomolecule mixtures through resolving overlapped Raman bands.
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Cites
Bendall, S. C., Simonds, E. F., Qiu, P., Amir, E.-A. D., Krutzik, P. O., Finck, R., Bruggner, R. V., Melamed, R., Trejo, A., Ornatsky, O. I., et al. (2011) · Science · doi:10.1126/science.1198704 · Cited by 2,279
Cited by
Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine
Cheng, J.-X., & Xie, X. S. (2015) · Science · doi:10.1126/science.aaa8870 · Cited by 874
Self-citationChemically sensitive bioimaging with coherent Raman scattering
Camp Jr, C. H., & Cicerone, M. T. (2015) · Nature Photonics · doi:10.1038/nphoton.2015.60 · Cited by 472
High-speed coherent Raman fingerprint imaging of biological tissues
Camp Jr, C. H., Lee, Y. J., Heddleston, J. M., Hartshorn, C. M., Walker, A. R. H., Rich, J. N., Lathia, J. D., & Cicerone, M. T. (2014) · Nature Photonics · doi:10.1038/nphoton.2014.145 · Cited by 469
Biological imaging of chemical bonds by stimulated Raman scattering microscopy
Hu, F., Shi, L., & Min, W. (2019) · Nature Methods · doi:10.1038/s41592-019-0538-0 · Cited by 392
Zhang, D., Li, C., Zhang, C., Slipchenko, M. N., Eakins, G., & Cheng, J.-X. (2016) · Science Advances · doi:10.1126/sciadv.1600521 · Cited by 389
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Metadata
- Authors
- Zhang, D., Wang, P., Slipchenko, M. N., Ben-Amotz, D., Weiner, A. M., & Cheng, J.-X.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-12-14
- Volume
- 85
- Issue
- 1
- Pages
- 98-106
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2094295322
- Cited by
- 242
- References
- 1
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- green
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