The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
High-speed coherent Raman fingerprint imaging of biological tissues
Open accessAbstract
An imaging platform based on broadband coherent anti-Stokes Raman scattering has been developed that provides an advantageous combination of speed, sensitivity and spectral breadth. The system utilizes a configuration of laser sources that probes the entire biologically relevant Raman window (500–3,500 cm–1) with high resolution (<10 cm–1). It strongly and efficiently stimulates Raman transitions within the typically weak ‘fingerprint’ region using intrapulse three-colour excitation, and utilizes the non-resonant background to heterodyne-amplify weak Raman signals. We demonstrate high-speed chemical imaging in two- and three-dimensional views of healthy murine liver and pancreas tissues as well as interfaces between xenograft brain tumours and the surrounding healthy brain matter. A high-resolution, broadband imaging system based on coherent anti-Stokes Raman spectroscopy performs rapid, chemically specific imaging of biological tissue. It employs three-colour excitation and operates across the entire biological window.
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Cites
Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy
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Single-pulse coherently controlled nonlinear Raman spectroscopy and microscopy
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Third-order optical susceptibilities of liquids and solids
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Diagnosing breast cancer by using Raman spectroscopy
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Cited by
Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine
Cheng, J.-X., & Xie, X. S. (2015) · Science · doi:10.1126/science.aaa8870 · Cited by 874
Raman Techniques: Fundamentals and Frontiers
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Chemically sensitive bioimaging with coherent Raman scattering
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Self-citationRapid single-particle chemical imaging of nanoplastics by SRS microscopy
Qian, N., Gao, X., Lang, X., Deng, H., Bratu, T. M., Chen, Q., Stapleton, P., Yan, B., & Min, W. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300582121 · Cited by 467
Raman spectroscopy: techniques and applications in the life sciences
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Metadata
- Authors
- Camp Jr, C. H., Lee, Y. J., Heddleston, J. M., Hartshorn, C. M., Walker, A. R. H., Rich, J. N., Lathia, J. D., & Cicerone, M. T.
- Venue
- Nature Photonics
- Published
- 2014-07-20
- Volume
- 8
- Issue
- 8
- Pages
- 627-634
- ISSN
- 1749-4885 (ISSN-L)
- 1749-4893
- OpenAlex
- W2045824562
- Cited by
- 469
- References
- 49
- FWCI
- 22.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Camp Jr, C. H., Lee, Y. J., Heddleston, J. M., Hartshorn, C. M., Walker, A. R. H., Rich, J. N., Lathia, J. D., & Cicerone, M. T. (2014). High-speed coherent Raman fingerprint imaging of biological tissues. Nature Photonics. https://doi.org/10.1038/nphoton.2014.145
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