The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Label-Free Quantitation of a Cancer Biomarker in Complex Media Using Silicon Photonic Microring Resonators
Open accessAbstract
Recent advances in label-free biosensing techniques have shown the potential to simplify clinical analyses. With this motivation in mind, this paper demonstrates for the first time the use of silicon-on-insulator microring optical resonator arrays for the robust and label-free detection of a clinically important protein biomarker in undiluted serum, using carcinoembryonic antigen (CEA) as the test case. We utilize an initial-slope-based quantitation method to sensitively detect CEA at clinically relevant levels and to determine the CEA concentrations of unknown samples in both buffer and undiluted fetal bovine serum. Comparison with a commercial enzyme-linked immunosorbent assay (ELISA) kit reveals that the label-free microring sensor platform has a comparable limit of detection (2 ng/mL) and superior accuracy in the measurement of CEA concentration across a 3 order of magnitude dynamic range. Notably, we report the lowest limit of detection to date for a microring resonator sensor applied to a clinically relevant cancer biomarker. Although this report describes the robust biosensing capabilities of silicon photonic microring resonator arrays for a single parameter assay, future work will focus on utilizing the platform for highly multiplexed, label-free bioanalysis.
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Cites
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Cited by
Advances in Microfluidic Materials, Functions, Integration, and Applications
Nge, P. N., Rogers, C. I., & Woolley, A. T. (2013) · Chemical Reviews · doi:10.1021/cr300337x · Cited by 958
Whispering gallery mode sensors
Foreman, M. R., Swaim, J. D., & Vollmer, F. (2015) · Advances in Optics and Photonics · doi:10.1364/aop.7.000168 · Cited by 927
Silicon Photonics Circuit Design: Methods, Tools and Challenges
Bogaerts, W., & Chrostowski, L. (2018) · Laser & Photonics Reviews · doi:10.1002/lpor.201700237 · Cited by 604
Single-molecule nucleic acid interactions monitored on a label-free microcavity biosensor platform
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Self-citationOptical ring resonators for biochemical and chemical sensing
Sun, Y., & Fan, X. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-4237-z · Cited by 355
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High-Q Optical Sensors for Chemical and Biological Analysis
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Self-citationBiofunctionalization of Multiplexed Silicon Photonic Biosensors
Puumala, L. S., Grist, S. M., Morales, J. M., Bickford, J. R., Chrostowski, L., Shekhar, S., & Cheung, K. C. (2022) · Biosensors · doi:10.3390/bios13010053 · Cited by 55
Room-temperature-deposited dielectrics and superconductors for integrated photonics
Shainline, J. M., Buckley, S. M., Nader, N., Gentry, C. M., Cossel, K. C., Cleary, J. W., Popović, M., Newbury, N. R., Nam, S. W., & Mirin, R. P. (2017) · Optics Express · doi:10.1364/oe.25.010322 · Cited by 38
Metadata
- Authors
- Washburn, A. L., Gunn, L. C., & Bailey, R. C.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-10-22
- Volume
- 81
- Issue
- 22
- Pages
- 9499-9506
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2041137211
- Cited by
- 318
- References
- 30
- FWCI
- 21.65
- Type
- journal article
- Language
- en
- Open access
- green
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