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Integrated Microfluidic Device for Automated Single Cell Analysis Using Electrophoretic Separation and Electrospray Ionization Mass Spectrometry
Open accessAbstract
A microfabricated fluidic device was developed for the automated real-time analysis of individual cells using capillary electrophoresis (CE) and electrospray ionization-mass spectrometry (ESI-MS). The microfluidic structure incorporates a means for rapid lysis of single cells within a free solution electrophoresis channel, where cellular constituents were separated, and an integrated electrospray emitter for ionization of separated components. The eluent was characterized using mass spectrometry. Human erythrocytes were used as a model system for this study. In this monolithically integrated device, cell lysis occurs at a channel intersection using a combination of rapid buffer exchange and an increase in electric field strength. An electroosmotic pump is incorporated at the end of the electrophoretic separation channel to direct eluent to the integrated electrospray emitter. The dissociated heme group and the alpha and beta subunits of hemoglobin from individual erythrocytes were detected as cells continuously flowed through the device. The average analysis throughput was approximately 12 cells per minute, demonstrating the potential of this method for high-throughput single cell analysis.
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Cites
Structure and mechanism of carbonic anhydrase
Lindskog, S. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(96)00198-2 · Cited by 1,022
Cited by
Mass spectrometry-based proteomics: existing capabilities and future directions
Angel, T. E., Aryal, U. K., Hengel, S. M., Baker, E. S., Kelly, R. T., Robinson, E. W., & Smith, R. D. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15331a · Cited by 441
Lombard‐Banek, C., Moody, S. A., & Nemes, P. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201510411 · Cited by 214
Redman, E. A., Batz, N. G., Mellors, J. S., & Ramsey, J. M. (2015) · Analytical Chemistry · doi:10.1021/ac503964j · Cited by 136
Self-citationLombard-Banek, C., Moody, S. A., Manzini, M. C., & Nemes, P. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00345 · Cited by 130
Black, W. A., Stocks, B. B., Mellors, J. S., Engen, J. R., & Ramsey, J. M. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b01179 · Cited by 35
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Metadata
- Authors
- Mellors, J. S., Jorabchi, K., Smith, L. M., & Ramsey, J. M.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-01-08
- Volume
- 82
- Issue
- 3
- Pages
- 967-973
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W1965437384
- Cited by
- 235
- References
- 1
- FWCI
- 13.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Mellors, J. S., Jorabchi, K., Smith, L. M., & Ramsey, J. M. (2010). Integrated Microfluidic Device for Automated Single Cell Analysis Using Electrophoretic Separation and Electrospray Ionization Mass Spectrometry. Analytical Chemistry. https://doi.org/10.1021/ac902218y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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