The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Relating Electrospray Ionization Response to Nonpolar Character of Small Peptides
Abstract
Nonpolar regions in biological molecules are investigated as a determining factor governing their electrospray ionization (ESI) mass spectrometric response. Response is compared for a series of peptides whose C-terminal residue is varied among amino acids with increasingly nonpolar side chains. Increased ESI response is observed for peptides with more extensive nonpolar regions. The basis for this increase is examined by comparing values of nonpolar surface area and Gibbs free energy of transfer for the different amino acid residues. Comparisons of response with octadecylamine are also made, and this highly surface-active ion is observed to outcompete all other analytes in ESI response. These observations are rationalized on the basis of the equilibrium partitioning model, which is used successfully to fit experimental data throughout the concentration range for several two-analyte systems. This model suggests that because excess charge exists on ESI droplet surfaces, an analyte's relative affinity for the droplet surface determines its relative ESI response. Increased nonpolar character, which leads to enhanced affinity for the surface phase, results in more successful competition for excess charge and higher ESI response.
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Cites
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Atmospheric pressure ion evaporation-mass spectrometry
Iribarne, J. V., Dziedzic, P. J., & Thomson, B. A. (1983) · International Journal of Mass Spectrometry and Ion Physics · doi:10.1016/0020-7381(83)87009-0 · Cited by 136
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Electrospray: From ions in solution to ions in the gas phase, what we know now
Kebarle, P., & Verkerk, U. H. (2009) · Mass Spectrometry Reviews · doi:10.1002/mas.20247 · Cited by 905
High-Resolution Native Mass Spectrometry
Tamara, S., den Boer, M. A., & Heck, A. J. R. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00212 · Cited by 511
Ferrer, C., Lozano, A., Agüera, A., Girón, A. J., & Fernández-Alba, A. R. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.07.033 · Cited by 485
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Proteomics of Integral Membrane ProteinsTheory and Application
Speers, A. E., & Wu, C. C. (2007) · Chemical Reviews · doi:10.1021/cr068286z · Cited by 325
Atmospheric aerosols as prebiotic chemical reactors
Dobson, C. M., Ellison, G. B., Tuck, A. F., & Vaida, V. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200366897 · Cited by 270
Peptide Correlation Analysis (PeCorA) Reveals Differential Proteoform Regulation
Dermit, M., Peters-Clarke, T. M., Shishkova, E., & Meyer, J. G. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.0c00602 · Cited by 40
Santa, T., Al‐Dirbashi, O. Y., Yoshikado, T., Fukushima, T., & Imai, K. (2009) · Biomedical Chromatography · doi:10.1002/bmc.1124 · Cited by 17
Abdul-Khalek, N., Picciani, M., Shouman, O., Wimmer, R., Overgaard, M. T., Wilhelm, M., & Gregersen Echers, S. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00973 · Cited by 13
Metadata
- Authors
- Cech, N. B., & Enke, C. G.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-05-23
- Volume
- 72
- Issue
- 13
- Pages
- 2717-2723
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W1967544219
- Cited by
- 342
- References
- 6
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- closed
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